Higher-order chromatin structure (architecture) plays the crucial role in DNA transcription, replication and repair. Defects to DNA architecture are permanently caused by internal cellular processes and various environmental factors, such as exposure to chemicals or ionizing radiation.
Humankind has witnessed unprecedented breakthroughs in (bio)medical sciences during the 20th and 21st centuries. A significant increase in life expectancy has cultivated the seeds of eagerness to live longer and healthier in the collective mind of humans.
The biological cancer hallmarks and the current model In the updated ongoing model, genomic instability and inflammation are the basis of all the cancer hallmarks: sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality,
The misfolding and subsequent aggregation into β-sheet rich assemblies of endogenous polypeptides, such as β-amyloid peptide, tau protein, α-synuclein, and insulin are the underlying causes of diabetes and many neurodegenerative diseases. Although, no sequence or structural similarity
Environmental pollution is one of the biggest challenges in the world today, as society faces the consequences of intense industrial development. The widespread use of pesticides in agriculture leads to high quality products, while minimizing losses in
“Life is a Journey” is a common metaphor used around the world. While this is a true picture of life, the journey theme can be useful to express a variety of processes. In healthcare, we talk about
Breast cancer has the highest incidence rate of all cancers in women worldwide. Although early breast cancer generally has an excellent prognosis, breast cancer in young women (under the age of 35) is associated with a high
Within the past decade, smartphones have been assimilated into the personal, social, and occupational routines of a significant proportion of people around the globe. In fact, previous reports show that more than half of the Western population
May polystyrene microplastics be ingested by marine organisms, affecting survival, growth and behavior?
World plastic production has increased steadily over the past 50 years, reaching over 350 million tonnes in 2018. Most of the plastic waste ends up in the oceans and it is constituted not only by large plastic
Human growth is influenced by genetic factors, but the genetic potential will be expressed if socio-economic and environmental conditions allow it. Anthropometric indicators like height and weight are used to characterize growth and development of children and
Undernutrition in children is one of the important global health issues. In the developing countries, the main cause of undernutrition is an inadequate nutritional intake due to the poverty. On the other hand, in developed countries, dieting
Research on novel materials to replace Si has been actively pursued for sustainable improvement of electronic devices. Ge has attracted attention as the most promising candidate for next-generation material because it has a higher carrier mobility than
Mitochondria are cellular organelles specialized for energy production, and critically influence several features of cellular metabolism and physiology. Maintenance of a healthy mitochondrial pool is a prerequisite for cellular and tissue homeostasis. Compromised mitochondrial function results in
An ischemic stroke is the sudden death of brain cells due to lack of oxygen and glucose, which is caused by blockage of blood flow to the brain. Stroke is a leading cause of death around the
Platelet transfusion is commonly used to prevent or treat bleeding in people with thrombocytopenia or platelet dysfunction. Among transfusable blood products, however, platelet concentrates (PCs), which also contain plasma, have a higher frequency of transfusion reactions than
The Figure of 8 Walk (F8W) test looks at walking in straight and curved paths in both clockwise and anti-clockwise directions (Fig. 1). The time taken to carry out the test is recorded along with the number
Kelps are a specific type of large brown seaweeds that generally grow on rocky, shallow, nutrient-rich ocean water. The most common examples of kelps found in the South African coastlines include Ecklonia maxima (sea bamboo) (Fig. 1), Ecklonia