Monthly Archives: February 2017

New discovered biomarkers as useful molecular targets in testicular germ cell tumors

Testicular germ cell tumors (TGCTs) are histologically classified as seminomas and non-seminomas according to the international classification of oncological diseases. Both these tumors display an invasive phenotype and are believed to be derived from a common ancestor,

The slippery head of the fastest fish

The swordfish (Xiphias gladius) is reputedly the fastest swimmer on Earth. Its concave head and iconic sword are unique characteristics, but how they contribute to its speed is still unknown. Our paper reports the discovery of a

Dysfunction of cellular analgesic control in neuropathic pain

Neuropathic pain in small-fiber neuropathy was traditionally considered a consequence of injury to nociceptors and sensitization. An alternative view has also been put forward: there may be a loss of the neuronal analgesic control system, paralleling the

Threats from antifouling priority pollutants in the Adriatic sea

To ensure the preservation of public health and ecosystems it is essential to reach a good chemical status of surface water bodies and groundwater. To this end, such waters should comply with the Environmental Quality Standards (EQS)

The promiscuous mineralocorticoid receptor

Hormones and nerves are the key communication systems in the human body. Nerves are like a fixed-line telephone network, capable of very fast messaging: think of the pianist’s fingers playing the Minute Waltz. Hormones are like radio,

Drugs from the sea: complex structures to fight a complex problem of resistance in cancer

It is well known that incidence of cancer cases figures among the leading causes of morbidity and mortality. Most of disseminated cancers share the common feature of not responding to anticancer drugs. This phenomenon is known as

Algae and moulds: Causative agents of respiratory tract disease in horses?

This investigation identifies the alga Prototheca and the mould Pithomyces chartarum as rare causes of upper respiratory tract inflammation in horses. More frequently, upper respiratory tract disease in horses is caused by viral and bacterial infections. Patients:

Microneedle patch for fast and sustained pain relief

The occurrence of pain is very common in routine life and during invasive clinical procedures, such as injections, surgeries etc. which is the usually treated using painkiller and local anesthetics in form of oral dosage forms, creams,

Lung cancer imaging before surgery and the role of brain MRI

Lung cancer kills more people each year than any other cancer worldwide. The best chance at curing the cancer is with surgery, however not all lung cancers can be taken out. Surgeons use a variety of imaging

Atelocollagen-conjugated miR-520d-5p is effective dramatically in therapy-resistant undifferentiated cancers

We have previously shown that hsa-miR-520d-5p can convert cancer cells into induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs) via the demethylation and consequent upregulation of TP53 in vivo. We have also reported that miR-520d-5p

Mechanism of the tumor suppressive properties of glycodelin

Malignant growth in cancer is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. In some cases it is possible to revert malignant cells back to normal. However, this process is not very well

Lipid modified natural RNA

tRNA is an integral part of the protein translation process. It translates the genetic code from mRNA to make the corresponding protein. The process of protein translation requires a well-defined structure of specific tRNA and its ability

The Fracture Liaison Service. A standardized order set towards efficient management of fragility fractures with minor expenses

Over more than a decade, the secondary fracture prevention strategy has been the heart of osteoporosis-related fracture management studies. Management programs have oscillated between low and high levels of intensity of intervention(s); sensitization through letters or pamphlets,

Stopping the spread of diarrheal disease through the environment

More than half a million children die every year from diarrheal diseases. Most of these diseases are caused by pathogens, or “germs”. In my paper Environmental Transmission of Diarrheal Pathogens in Low and Middle Income Countries published

Small dense LDL, sub-clinical atherosclerosis and psoriatic arthritis

Psoriatic arthritis (PsA) is a chronic arthropathy associated with psoriasis, marked by an axial and/or peripheral joint involvement and high cardiovascular. Several large  studies confirmed the relationship of small dense LDL (sd-LDL) with coronary events. Although some

Acute stroke in 3 brain territories suggests cancer

Over the past several decades cancer has increased to rival heart disease as the leading cause of death in the United States. Non-infectious endocarditis and cancer-associated hypercoagulation (C-AH) have both been suggested as a source of stroke