Monthly Archives: March 2017

Inhaled metal oxide nanoparticles’ retention in the pulmonary tissue can be hindered by their relatively high solubilization counterbalancing their unfavorable action on the free pulmonary cells response

We hypothesized that pulmonary clearance vs. retention of metal oxide nanoparticles (NPs) is controlled not only by activity of phagocytes and other physiological mechanisms but also by the NP solubilization which, in some cases, may even prevail

Insulin effects on pancreatic beta cells-not always what you may think

Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of

A synthetic natural like product endowed with antiproliferative activity

The World Health Organization has reported that cancer is one of the major causes of morbidity and mortality affecting population in all countries and regions. The 2014 World Cancer Report of WHO indicated that in 2012 there

What all can your child eat apart from food: coins, magnets or more?

Ingestion of foreign bodies is a common paediatric problem. The majority of ingested foreign bodies pass spontaneously. The type of foreign body differs depending on the age and eating habits of the subject. Thus, foreign bodies found

Capturing neon within crystalline frameworks to aid semiconductor manufacturing

Neon is one of the least reactive elements known. No molecules containing neon have so far been synthesised and it is the only stable element that has never previously been studied within an organic crystal structure, despite

A new technology for employing artificial trans-acting small interfering RNA

A central doctrine for a gene expression is typically from the DNA coding sequence to the RNA transcript and then to the protein. So, the normal function of a gene can be disrupted by suppression, or so-called

Production and diseases of dairy cows: genetics (cause) and management (effect)

The milk production of dairy cows has been increased during the last decades by animal-husbandry, improved feeding regime, extensive veterinary service and proper management. It can be assumed that this tendency will be continued in the future

Measuring motivation in Parkinson’s disease through the eyes response to money

Apathy or a lack of motivation is a disabling condition making patients feel that they “just can’t be bothered to do things”. Apathy is very common in Parkinson’s disease, affecting up to 70% of patients and causing

Do children with Autism Spectrum Disorder understand the representational meaning of the eye gaze?

Gaze following is crucial for human social cognition, this ability develops from a low-level perceptual mechanism to a representational one. In typical development, between 6 and 12 months, infants perceive the gaze as a directional cue that

Candidate gene analysis of osteochondrosis in Spanish Purebred horses

Equine osteochondrosis (OC) is a frequent developmental orthopaedic disease (DOD) with high economic impact on the equine industry. The multifactorial origin behind its aetiology, including genetic, vascular or biomechanical influences, as well as other environmental factors such

Ankylosing spondylitis: what you should know about spinal fractures

The aim of this review article was to provide the required clinical knowledge that radiologists need to know and the relevant radiological semiotics that clinicians require in diagnosing clinically significant injuries to the ankylosed spine. Ankylosing spondylitis

The positive resting membrane potential of non-excitable fibrocytes in the mammalian cochlea

It is schoolbook knowledge that both excitable and non-excitable cells are stably hyperpolarized at -25 mV to -80 mV in the resting state in vivo and in vitro. This negative resting membrane potential (RMP), a fundamental cell

Too little sun-exposure in summer?

It is well known that UV rays are responsible for DNA damage in exposed cells: because of that, they are considered carcinogens for skin cells. In the last decades, frequent worldwide campaigns have advised people to avoid

Why is anxiety more common in women? Investigating sex differences in threat and safety learning

Anxiety-related disorders like post-traumatic stress disorder (PTSD) are up to twice as common in women as in men but the reasons behind this remain unclear. People with PTSD often experience negative emotions like fear when reminded of

Repelling water and dirt: superhydrophobic biological surfaces and biomimetic innovations

Life evolved over the last 3.5 billion years: a continuous process of mutation and selection – or trial and error. Today we know of some 1.8 million different species – but assessments indicate the existence of over

Cerebellar and brainstem malformations

The development of the cerebellum and brainstem is a highly complex process that involves a large number of genes. Mutations in these genes may cause an abnormal development of the cerebellum and brainstem and result in several