Monthly Archives: May 2017

The role of monocytes in ANCA-associated vasculitides

The anti – neutrophil cytoplasm antibody (ANCA) – associated vasculitides (AAV) include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). These rare systemic autoimmune diseases affect small and medium – sized blood vessels, and are characterized by necrotizing vasculitis,

Diagnosing Fragile X syndrome by DNA methylation array

Fragile X syndrome (FXS) is the most common genetic condition which causes a range of developmental problems and intellectual disability in males. It is caused by a mutation in the fragile X mental retardation gene (FMR1), which

What are the psychological drivers of religious history?

When the Buddha became “Enlightened” he realised that what is important about human beings is their ethical intentions.  These are the grounds of karma in Buddhism.  And he realised too that everything we call a “thing” is

“Contagious and bad”. The stigma of Mycobacterial infections

Two diseases caused by mycobacteria, Tuberculosis and Leprosy, not only are they quintessential in the history of infectious diseases and humanity, but have survived the passing of the centuries still affecting millions around the world. Being present

Application of ultrasensitive electrochemical biosensors for specific analysis of a glycan on a prostate-specific antigen

Prostate cancer (PCa) is the second most common cancer worldwide, accounting for more than 1.1 million cases in 2012.  The statistics says, that about 1 man in 7 will be diagnosed with PCa during his lifetime with

A figure-of-eight molecule twists the red light

Development of fluorophores for CPL, circularly polarized luminescence, has attracted much attention. CPL has large potential toward future applications such as 3D displays and biosensing.  Major challenges in creating good CPL fluorophores are; 1) large anisotropic dissymmetric

New types of functional pasta enriched with lyophilized tomato or wheat bran antioxidant extracts

The increasing demand for healthy foods has encouraged food companies to direct new research and development activities towards products providing, beyond basic nutritional functions, beneficial effects for health and/or reducing the risk of chronic diseases, i. e.

A calixarene derivative mediates rapid detoxification of the deadly poison VX

On 13th February 2017, the half-brother of the North-Korean dictator Kim Jong-un was poisoned, supposedly with one of the deadliest known chemicals, namely, the nerve agent VX (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate). This poison is so effective that contamination

Cushing’s, coping and quality of life

Cushing’s disease (CD) and Cushing’s syndrome (CS) are rare illnesses in which the body is flooded by an excess of the hormone cortisol, leading to characteristic and severe symptoms, among them central weight gain, easy bruising, diabetes

Stanford scientists use nanotechnology to boost the performance of a key industrial catalyst

Nanoscale stretching or compressing significantly boosts the performance of ceria, a material widely used in catalytic converters and clean-energy technologies. A tiny amount of squeezing or stretching can produce a big boost in catalytic performance, according to

Molecular mechanism of phenotypic plasticity

Darwinian evolution is considered to be the way that life adapts in every possible environment in Earth. The great evolutionary biologist of the past century Theodosius Dobzansky used to say: “Nothing in Biology Makes Sense Except in

Conformal invariants for landmark curve based brain morphometry analysis

Abnormal structural changes measured on cortical surfaces are important biomarkers for Alzheimer’s disease (AD). In brain imaging research, landmark curves are usually delineated on cortical surfaces to represent significant sulcus and gyrus patterns. Landmark curves are widely

Osteosarcoma – lost in translation

A 16-year-old boy with pain around the knee of two months’ duration demonstrates a lesion in the epiphysis of the distal femur (long bone). The differential diagnosis may be broad, but the pathologist is able to achieve

Milk of breast is best: protection against RSV and subsequent wheeze with breastmilk

Respiratory syncytial virus (RSV) is a significant pathogen infecting infants and young children; approximately 70% of infants are infected with RSV before their first birthday and almost all children have been infected at least once by two

A potential radiotracer for imaging the lungs

Routine patient lung scans in the nuclear medicine department have for decades, employed a radioactive technetium-99m-aggregated-albumin particle injection dose, in conjunction with a ventilation dose of Tc-99m-aerosol in tandem. The lung scans are usually requested for patients

Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade

Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,