Monthly Archives: December 2017

The vision thief

Glaucoma is often called the sneak thief of vision because it can develop without obvious symptoms. Although some risk factors, such as high intraocular pressure, are apparent, how these factors contribute to the disease is by no

How does histamine make it hard to breathe?

Histamine is a chemical substance that can be released in the lungs to cause narrowing of the bronchial tubes and difficulty breathing. Airway smooth muscle cells in the bronchioles (small airways) of the lung can contract or

What happened in the dental offices in the 1970s and -80s?

Copper has a long history as an ingredient in mercury based tooth fillings, so called dental amalgams. The old type of copper amalgam (approx. 70% mercury and 30% copper) was provided in the form of tablets and

Assaying protein-protein interaction by the complementation of firefly luciferase catalytic steps

Protein – protein interaction (PPI) assay is a key technology for various fields from basic molecular biology to diagnosis and drug discovery. Previously, PPI assays based on fluorescence resonance energy transfer (FRET), bioluminescence resonance energy transfer (BRET)

Nuclear shuttling of key methionine cycle enzymes in acute liver injury

Important metabolic enzymes have been classically ascribed to certain subcellular locations, where they perform their well-known function. In the last decades, several technological advances have allowed detection of these proteins in new locations, performing either their known

Injectable hydrogels for microfluidic platforms

Combining biological processes and microfluidic platforms have recently attracted significant attention due to the possibility to fabricate devices for diagnosis of wide range of disorders. Although many immobilization techniques have been established for such systems, developing proper

Type 2 diabetes can originate in utero

Type 2 diabetes (T2D) is considered to be adult-onset disease, since it typically occurred in middle-age and old adults. There is, hovewer, increasing evidence that risk for development of T2D can be influenced not only by adult

A novel sperm structure solve a mystery

How the embryo obtains some of it’s organelles is still a mystery. We know that the nucleus that contains the genetic code comes from the father and the mother via the sperm and egg. We also know

Multifunctional molecular siblings

The interaction of light with matter always ignited the curiosity of researchers and has been a driving force for the discovery and development of new theories, niche technology and novel functional materials. Light emission from an electronically

Recurrent ontogenesis

Flowering plants arose during the Cretaceous, and up to date they count around 235,000 species, representing the largest and most diverse group within the plant kingdom. One of the foundation of their success relies upon the production

20th-century version of an old pathogen. Drug resistant tuberculosis

Mycobacterium tuberculosis the causative agent of human tuberculosis (TB) is consider the most successful pathogen  that could infect (2 billion), induce (10.4 million) and kill (1.7 million) a large number of people around the world. Besides this

Is caveolin-1 depletion the key to endothelial cell phenotypic switching in inflammatory vascular disease?

Endothelial cells (ECs) function as the central regulators of blood – tissue communication, controlling the exchange of solutes and immune cells between the vascular and extravascular compartments. In healthy lungs, quiescent ECs express high levels of caveolin-1

Fatigue and torsional resistance of controlled memory and conventional nickel-titanium endodontic instruments

The endodontic field encountered an important breakthrough with the introduction of the nitinol alloy. It offers special mechanical properties like a shape memory effect and superelasticity. Despite of the particular properties of NiTi instruments, they could suffer

Biophysical characterization of the potential role of polar lipids for the stability of tear films

The tear film is a thin structure that covers the surface of the eye. It functions as barrier to evaporation, foreign particles, and bacterial infection. These roles can be primarily attributed to the tear film structure and

Natural aging as a sequential poly-systemic syndrome

A generalized approach to aging is possible based on the General System theory of aging, predicated on the General Model of aging. The fundamental cause of aging is the law of entropy increment in incompletely open systems.

The cation channel of sperm modulates boar sperm motility during capacitation

The male gamete, the spermatozoon, is a highly specialized cell with a trimmed shape, far from the original cells of origin in the testicles. Their primary function is to deliver the paternal gene component of the new