Yearly Archives: 2018

How does Parkinson’s disease gets from your gut to your head?

Parkinson’s disease (PD) is defined as a movement disorder, characterized by a symptomatic phase of motor disturbances such as tremor and slow movements resulting from the severe degeneration of dopaminergic neurons of the substantia nigra pars compacta

Mimicking enzymes using artificial proteins

Critical to life on earth is the ability of proteins called enzymes to catalyze a wide range of chemical reactions, such as producing essential molecules by breaking down food in humans, and producing oxygen from water in

Multi-scale mechanical characterization of prostate cancer cell lines

Cellular mechanics are of prime importance in the birth and the evolution of tumors towards increasingly aggressive stages and are often proposed as potential biomarkers to evaluate metastatic potential. Mechanical properties of two human prostate cell lines,

Decrypting the secret of Swarna Bhasma, an ancient Ayurvedic/Sidha medicine. Swarna Bhasma, ancient Ayurvedic medicine, meets human cells

Ayurveda is an indigenous medical system of natural healing, with roots in folk medicine, in practice on the Indian subcontinent since at least 5000 years. It adopts a holistic approach towards health, emphasizing the connection between the

Unregulated oxygen levels in mammalian cell culture changes cell physiology

As aerobic organisms we continuously utilize oxygen from the surrounding environment which ultimately participates in the formation of useful bioenergetic intermediates. Approximately 21% of the air we breathe is composed of oxygen, but the quantity of oxygen

Does inadequate sleep hours and snoring relate to chronic disease?

Sleep is one of the fundamental requirements for survival of human beings. Yet an outrageous number of population neglect its’ importance. Although most people tend to think that lack of sleep (<7 hours) is more detrimental to

Muscle wasting with chronic diseases: Can Sirtuins fix the problem?

Prognosis of a chronic disease worsens when associated with uncontrolled muscle loss. Muscle wasting can become the last nail in the coffin when accompanied with chronic diseases like cancer, heart failure, chronic obstructive pulmonary disease and infective

Niobium oxide cluster ions grow to have more compact structures than vanadium oxides

Compositions and geometrical structures of niobium oxide cluster ions, NbmOn± (m ≤ 12), were studied comparing with the lighter Group 5 counterpart vanadium oxide cluster ions by ion mobility mass spectrometry (IM-MS). As a result of collision

Horny skin layer enhances the skin barrier function and water bonding with increasing age

Human skin consist of three layers – epidermis, dermis and subcutaneous tissue. The main age–related changes in the skin are well investigated for the dermis and include the delay of bio fluids’ microcirculation, reduced synthesis of extracellular

Menthol makes harder to quit nicotine-seeking behavior

Even though almost all smokers want to quit smoking and have made attempts to do so, the majority eventually relapses and continues to smoke. In the United States, in contrast to the overall significant progress in reducing

What pH at the sites of calcification of an octocoral tells us

Corals are marine organisms which elaborate calcium carbonate skeletons, a process known as biomineralization or calcification. This process involves the regulation of ions at the site of calcification together with the synthesis of organic molecules such as

How can we understand persistent pain?

Acute pain evoked by tissue injury makes biologic sense and can be explained mechanistically in great detail. It is much more difficult to understand why pain so often persists after healing of an injury, or even arises

B-vitamins over-consumption may be the cause of the increased prevalence of obesity and diabetes

Obesity and type 2 diabetes have been a major health issue in the United States. It is during the past few decades that obesity and type 2 diabetes have rapidly reached epidemic levels not only in adults

Ultra Quick sample preparation prior to GC-MS based metabolomics

Metabolomics is a comprehensive study of low molecular weight compounds in biological samples and has been applied to wide range of research areas from medical to food analysis. For the analysis of metabolites, gas chromatography-mass spectrometry (GC/MS)

Statin therapy makes things worse for alcohol drinkers

High cholesterol levels in humans represent a risk factor for life-threatening cardio/cerebrovascular conditions, including heart attack and stroke. It is estimated that nearly 94.6 million, or 40 % of American adults, have total blood cholesterol levels above

How healthy the Indian leopards are?

Carnivores face a continuous threat for their survival from pathogens, indirectly resulting from anthropogenic factors such as human population expansion, habitat loss or its alteration and climate change leading to their endangerment in the wild. These effects