Monthly Archives: February 2018

Prolactin regulates neurovascular coupling in male psychotic patients

Recent studies indicated that increased prolactin levels have negative effects on cognitive function in non-psychiatric populations and impair processing speed in patients with psychosis. According to the basic research, prolactin induces regional vasoconstriction via the inhibition of

‘DNA Fossils’, ancient mtDNA preserved in the nuclear genome: witnesses of human evolution milestones

Fragments of mitochondrial DNA (mtDNA) are known to get inserted into the DNA of the cell nucleus (i.e., our main genome) and to form NUMTs, i.e. dysfunctional sequences, nuclear pseudogenes of the mtDNA. Hundreds of NUMTs have

Human protein phosphatases: Proteomic insights

Protein phosphorylation-dephosphorylation, carried-out by kinase and phosphatases respectively, serves as major regulatory switch for controlling nearly all signaling processes. So far, the kinases remained a centerpiece in driving the functional response to signaling changes. However, more recently,

When the butterflies in the stomach prevail over the rationality: the case of alexithymia in intertemporal decision making

We are frequently faced with choices differing in the timing of their consequences, also called intertemporal choices. An example might be the following: should I spend my money now in an expensive holiday or put it into

The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia

Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and

CMR in pediatric HOCM: correlation with LV function, echocardiography and demographic parameters

Hypertrophic cardiomyopathy (HCM) is the most common inheritable cardiac disorder, with an estimated prevalence of 1:500. Although the disease is compatible with normal life expectancy, it is associated with premature death from ventricular arrhythmia, heart failure, and

Lessons from the Global Fund’s fight against AIDS, Tuberculosis and Malaria

At the beginning of this century, developing countries – particularly in Africa – experienced rapidly rising illness and death from AIDS, Tuberculosis, and Malaria. The three diseases caused massive suffering and economic damage. Treatment and interventions to

Transmitted sound wave mammography

This study was designed to look at a new type of totally harmless breast imaging called whole-breast transmission ultrasound to see if it could do something mammography cannot do – that is to diagnose the presence of

The eye gets stronger after seeing the world in chaos

Resembling the fact that some people are left-handed while some are right-handed, our two eyes are not functioning equally. Usually, our brain has a preference to the input signals from one of the two eyes, which is

A novel PET radiotracer for molecular imaging of the α3β4 nicotinic acetylcholine receptor

Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels that mediate fast synaptic transmission in the brain. These receptors are homo- or hetero-pentameric combinations of the α and the β subunits which each subtypes

What it takes to survive a transplant

Many patients with blood cancers, such as multiple myeloma, leukemia, or lymphoma, have radiation treatment or chemotherapy to destroy their tumor cells and diseased bone marrow. Unfortunately the treatment damages their immune system leaving them immunocompromised. To

Overproduction of membrane-integral undecaprenyl pyrophosphate phosphatase from Vibrio vulnificus

In the cytoplasm, undecaprenyl pyrophosphate (C55-PP) is synthesized by undecaprenyl pyrophosphate synthase (UppS) through consecutive condensation reactions of eight molecules of isopentenyl pyrophosphate (Ipp) with farnesyl pyrophosphate (Fpp). The product C55-PP is then dephosphorylated to monophosphate undecaprenyl phosphate

RKIP and YY1: The ‘good’ and the ‘bad’ shields in the protection of cancer spreading and resistance to therapies

Cancer originates from all of the uncorrected mutations occurring in the DNA of the cell that lead to abnormal cell growth. Accordingly, the accumulation of these mutations transforms a normal cell into an “immortal” cancer cell with

Mind-wandering plus mindfulness: say ‘no’ to negative mood or depression

Mind wandering and its equivalent concepts such as self-generated thought, stimulus independent thought, task-unrelated thought, and spontaneous thought refer to a mental phenomenon that occupies considerable time in everyday life. The high frequency of the occurrence of

The aptamer BC007: for the treatment of “functional autoantibody diseases”. First developed for patients with dilated cardiomyopathy

Autoimmunity is accepted as the origin or amplifier of various diseases. In the mid-1970s, a new class of “so-called” functional autoantibodies that bind to G-protein-coupled receptors (GPCR-AABs) was identified for downstream pathologies. The related “functional autoantibody diseases”

Chagas disease a neglected ills without treatment

Chagas disease (CD) is transmitted by the parasite Trypanosoma cruzi, and was discovered in 1909 by the Brazilian medical doctor named Carlos Chagas. Until today, CD remains a serious public health problem, with more than 7 million