Monthly Archives: June 2018

Nischarin regulates energy metabolism

Nischarin is a novel protein that is discovered by us. We demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. Previously we have shown

Novel anti-inflammatory adjuvants for vaccines to prevent and/or treat autoimmune diseases

The increase during the last 30 years in the incidence of autoimmune diseases (AD) in the developed countries, points to environmental rather than genetic risk factors. Indeed, studies have shown that ADs are rare in countries where

Plateau-like versus sawtooth-like force-extension response of macromolecules

In recent years, the folding and unfolding of single macromolecules has been largely investigated through atomic – force microscopes (AFM), laser optical tweezers (LOT) and magnetic tweezers (MT), which are able to apply external forces directly to

Why genomic research must be diverse and inclusive

In April 2003, the world witnessed the completion of the human genome project: a grand scientific feat comparable to man’s first steps on the moon. This 13-year, publicly funded undertaking determined the DNA sequence of the human

Generating hit molecules against pathogenic DNA motifs in silico

Genome (all the information that is encoded in DNA or RNA and is capable of being passed on to an offspring) is the blueprint of an organism. It consists of a sequence of letters A, G, C,

The dichotomy of exosomes in cancer: targets and treatment vehicles

Exosomes are extracellular vesicles released by all cell types that mediate intercellular communication. Exosomes exist in healthy as well as pathological conditions, but it is in cancer research that they are gaining increasing attention. Exosomes released by

Metformin and AMPK link cancer stem cell elimination with the potential eradication of HIV

Cancer stem cells (CSCs) are cancer cells that exhibit several stem cell-like qualities that are characteristic of embryonic or adult stem cells, including self-renewal, differentiation, and the ability to initiate tumorigenesis. CSCs, similar to adult stem cells

Increased blood immune regulation in autoimmunity?

Through centuries, the immune system evolved to become highly proficient in protecting the human body from invading threats. Part of its strength relies on antibodies produced within germinal centres (GC). These structures form intricate networks of immune

Differential diagnosis of neurodevelopmental syndromes using blood episignatures

Neurodevelopmental syndromes refer to a group of inborn diseases that present with impairments of the growth and development of the brain, and facial and somatic dimorphism. The differential diagnosis of these disorders is challenging because of the

Curing glioblastoma with oncolytic virus and immune checkpoint blockade

Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint

Friendly supporter or unfriendly disrupter? Understanding extraordinary phenomena under high humidity for novel oxychloride photocatalysts

Water, a strongly polar molecule made up of hydrogen and oxygen, is indispensable for human beings as well as all living organisms. We obtain energy for our activities mostly from oxidation of food, but tracing this back

Soft-diet feeding impairs olfactory functions via changes in neural connections

Mastication ability correlates with cognitive impairment in elderly persons. A longitudinal study of aging and Alzheimer’s disease indicates that participants with the fewest teeth had the highest prevalence and risk of incidence of dementia. There are abnormalities

Keyhole heart valve surgery after previous heart transplantation

Advances in heart transplant techniques and medication that control rejection and infections resulted in improved survival and quality of life. These improved long term outcomes are unfortunately paralleled by a variety of associated coronary-, mitral- and tricuspid

Hormones and endocrine disruptor compounds

Endocrine Disruptor Compounds (EDCs) are molecules, natural or synthetic, that happen to interfere with the endocrine network of vertebrates, provoking adverse dysregulation of the hormonally – controlled physiological parameters or functions. This interference can occur through different

Dilemma of a beneficial narcotic analgesic: Tramadol

Tramadol is a known opioid drug that is used worldwide to relieve moderate to severe pain. It is the sole over-the-counter narcotic drug, meaning that it can be purchased without a physician prescription. Most people can enjoy

How to turn bacterial metabolism into a deadly antibacterial weapon

The development of bacterial infections on and around biomedical materials, ranging from hip implants to wound dressings, is a large and growing problem. Biomaterial-associated infections are challenging to treat because bacteria tend to form colonies, called biofilms,