Bimetallic nanoparticles-based biosensor for managing diabetes
The glycated hemoglobin test gives the information about average level of blood sugar over the past 2 to 3 months. It’s also called HbA1c, glycated hemoglobin test, and glycohemoglobin. Persons who have diabetes require this test regularly to see if their levels are staying within range. The glucose level measurement in the diabetic patient plays a vital role in identification of the treatments going on and it also provides the control over the diabetics.
A new electrochemical sensing device was constructed for determination of HbA1c in whole blood samples. Fructosyl amine oxidase (FAO) was bioconjugated onto hybrid nanocomposite i.e., gold nanoparticles-platinum nanoparticles (AuNPs-PtNPs) and poly indole-5-carboxylic acid (PIN5COOH), deposited electrochemically on gold electrode. Bimetallic nanoparticles not only show their individual properties but also provides the synergistic effect between the two noble metal nanoparticles. AuNPs-PtNPs shown as an amplified sensing interface at lower voltage which makes the sensor more sensitive and specific.
The FAO/AuNPs-PtNPs onto PIN5COOH/Au electrode shows a promising future in diagnosis of HbA1c and diabetes management. The novel sensor formed has good accuracy, selectivity, sensitivity, precision and reliability. In addition to these, it showed good storage stability and retained 50% of its initial activity within 12 weeks at 4°C.
Amity Institute of Nanotechnology (AINT), Amity University, Noida, India
Construction of an amperometric glycated hemoglobin biosensor based on Au-Pt bimetallic nanoparticles and poly (indole-5-carboxylic acid) modified Au electrode.
Jain U, Gupta S, Chauhan N
Int J Biol Macromol. 2017 Dec
|Managing diabetes with 3D nanostructured Researchers have synthesized a sensitive nanosensor that can monitor the blood glucose levels though glycated hemoglobin (HbA1c) detection. HbA1c monitoring is very useful for patients suffering from Diabetes which provide…|
|Nanosensor for diabetes management Diabetes is a major health concern for millions around the world. In addition to the analysis of free glucose level in blood, glucose bound to haemoglobin (HbA1c) is considered to…|
|Gold-silver nanoparticles instead of traditional… Recently, we have published a pioneering work on green biosynthesis and complete characterization of gold and core shell silver-gold nanoparticles (AuNPs and Ag@AuNPs) via using green biopolymer in the influence…|
|The earlier, the better and the controlled. Glucose… Gone are the days when there was a big pain for patients suffering from high blood glucose (blood sugar) level that early and rapid detection was a long wait &…|
|EGCg-AuNPs Nanotherapeutics – as an… Cardiovascular diseases are the leading cause of morbidity and mortality in the United States and globally. However, despite remarkable technological advances, significant limitations remain in stent-based treatment. Therefore, it is…|
|Long-term outcome in patients admitted with a heart… An Oral Glucose Tolerance Test ( OGTT ) is one of the diagnostic tests to determine the presence of pre - diabetes or manifest diabetes. An OGTT involves drinking a…|