Category Archives: Research

A new strategy to drug development for neuromuscular disorder

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a neurodegenerative disease in which motor neuron (MN) loss in both the spinal cord and motor cortex causes progressive paralysis, muscle atrophy, and death. So far,

Physician-pharmacist collaboration: improving patient care through an interdisciplinary approach

General overview of physician-pharmacist collaborative management Within primary care settings, contemporary collaborative practices have aimed to embed the clinical pharmacist into a team-based-care model. Often referred to as the physician-pharmacist collaborative management (PPCM), it has recently been

Domain strain-engineering for epitaxial ferroelectric thin films by sputtering

The integration of multiferroic materials in the new generation of nanostructured electronic devices requires precise and orderly control of the thin films growth, taking into account the nature of such materials to develop domain structures, that is,

Infectious Leptospira cross-talk with host catecholamine’s during infection

Leptospira belongs to the family Leptospiraceae and the pathogenic species cause a zoonotic disease called leptospirosis. Leptospirosis is a worldwide zoonotic infection of human and veterinary concern, with approximately over one million cases reported annually. This disease

How can you tell that stem cells are good at math? You can watch them multiply and divide!

Blood production is an essential process in all vertebrate animals that needs to occur throughout an organism’s lifespan; red blood cells need to carry oxygen to distant tissues, platelets are required for stopping bleeding after injuries, and

Extracellular enzymes detecting heavy metal pollution in the Ganga River

India with more than 1.25 billion peoples is facing a significant challenge in meeting the growing water supply needs of burgeoning human population. Ganga, the most sacred river of India, that supplies water to over one fourth

Unlocking a cure from within for X-linked diseases

The mammalian X chromosome is home to many genes that are important for brain development and function, as well as genes associated with reproduction. More than 200 disease-causing mutations have been identified on the X-chromosome. Diseases caused

Fruit of the heirloom: ancient non-commercial plant varieties as superior sources of health-beneficial compounds

Lands subtracted to intense urbanization are home of a rich biodiversity, which is well exemplified by the occurrence of many different plant species. Plants thriving in such areas have established a perfect synergy with the local environment,

Excessive vascular fibrosis predicts early failure of hemodialysis fistulas

Patients with end-stage renal disease require a functional vascular access to receive hemodialysis and prolong their lives. The arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis. The AVF is surgically created by connecting a superficial

Opium use increases the chance of pancreas cancer in a large population-based study

Pancreas cancer is a common cancer with few treatment options and as a result is associated with considerably reduced chances of survival for the patients. Several factors such as obesity, diabetes, and smoking (including smokeless and other

How can we make nanoparticles more effective against cancer?

Chemotherapy is an integral part of the present cancer treatment paradigm, despite its common and severe side effects. Nanotechnology provides a plethora of promising avenues for overcoming chemotherapy limitations. Drug encapsulation within nanoparticles helps to retain it

Tissue-specific MED1 LxxLL motifs play critical roles in HER2-driven breast cancers

Estrogen Receptor (ER)  is a nuclear hormone receptor that plays important roles in normal mammary gland development as well as breast cancer growth and metastases. In a breast cancer setting, when ER is bound by estradiol, there is

Aggregation properties as potential markers for classifying rubber particle proteins

Natural rubber is an important biopolymer that mainly consists of cis-1,4-polyisoprene. The rubber tree Hevea brasiliensis is the only commercially viable source of natural rubber because of its good yield and the product’s high quality. Rubber elongation

A cool new way to cool (or warm)!

The cooling or warming of patients being treated for certain medical conditions can greatly increase their chance of survival. For example, survival after cardiac arrest can be almost doubled if the patient is gently cooled for about

Cannabis sativa: not just Devil’s weed

When hearing about Cannabis sativa, we undeniably think about marijuana and its addiction. However, C. sativa grown for industrial use has a Δ9-tetrahydrocannabinol (THC, a psychoactive component) content <0.3% and has instead a high number of cellulosic

A vaccine candidate for Zika with potential for reduced risk of antibody-dependent enhancement (ADE)

Zika virus (ZIKV) is a mosquito-borne flavivirus that has rapidly extended its geographic range. Its association with abnormal fetal brain development, sexual transmission, and lack of a preventive vaccine have constituted a global health concern. Designing a

Hinokitiol (Beta-thujaplicin) has an ability to inhibit action potential conduction in nerve fibers

Hinokitiol, a natural tropolone derivative contained in a species of cypress tree, has various actions including inhibition of apoptosis, and insecticidal, anti-fungal, anti-tumor, anti-bacterial, anti-inflammatory and cytotoxic activities. We previously reported that plant-derived chemicals (capsaicin, menthol and

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are

A new class of antisense RNAs that regulate gene expression

Cellular senescence is characterized by a stable cell proliferation arrest in response to different stresses such as oncogene activation. It is thus considered as a major anti-cancer barrier. However, the accumulation of senescent cells can lead to

Midkine controls natural bypass growth by regulating the bioavailability of VEGF

Cardiovascular occlusive diseases such as stroke, myocardial infarction or perivascular artery diseases (PAD) are a major personal and social burden. According to the World Health Organization, vascular occlusive diseases are the leading cause of death worldwide.  Current