Category Archives: Research

The NO-heme signaling hypothesis

The importance of the NO-synthase(NOS)/soluble guanylyl cyclase (sGC) signaling for health and disease is undisputable (Nobel Prize in Biology and Medicine, 1998). Many studies demonstrated that this pathway is critically implicated in the regulation of cardiovascular, nervous,

Not only pasta: using durum wheat semolina for producing high quality Dittaino bread

Artisanal agri-food products are obtained according to traditional recipes and processing technologies, with features of high quality and genuineness. The “protected designation of origin” (PDO) quality mark identifies a food product whose features strictly depend on the

A new strategy to deliver anti-cancer nanodrugs and decrease their toxic side effects by temporarily blunting the RES uptake using Intralipid®

Nanodrugs, or nanotechnology-based therapeutics, show great promise for treating a number of diseases, including cancer. However, an analysis of the literature from the past 10 years finds that in studies of cancer nanodrugs, a very small fraction

Head in the trough

A healthy and alert clinician is safer and more effective. It has long been known that doctors and surgeons work long and demanding hours with changing shifts, in an environment where the stakes are high. The risk

Can we treat cancer by targeting Treg subset without causing autoimmune disease?

The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also

Setting the epidemiological scenario of HCV infection in the islands of the Amazon region

Hepatitis C virus (HCV) infection is a major health problem. This viral infection is related to several serious clinical complications. About 2.2% of the world’s population is infected with HCV, most infected are asymptomatic and unconscious of

Ecdysone induces a termination of encapsulation via GBP-GBPB interaction

Insects have evolved various defense strategies involving both humoral and cellular immune responses to combat invading foreign pathogens. Encapsulation is a conserved cellular immune process targeted against any foreign intruder which is too large to be phagocytosed.

High-quality interactions with caregivers linked to larger vocabularies among toddlers born preterm

In the United States, approximately 1 in every 10 infants is born preterm. The smallest and youngest of these children at birth are at risk for delays in their development. For example, as a group, these children are

Fluctuating deformation of borosilicate glass

Glass is hard and brittle at room temperature, but can be very soft when it is heated to above its glass transition temperature. That is the reason that glass craftsmen can create various shapes of beautiful glassware.

More than just a reward molecule, dopamine helps us avoid harm

It is well known that the mesocorticolimbic dopamine system guides behavior as animals seek rewards from their environment. During the pursuit of reward, subsecond dopamine release events within this pathway represent information related to the rewarding outcome

Mechanistic details of a copper-catalyzed C-H oxidative cyclization

Exploiting chemical or biological reactions by different spectroscopic techniques has become a powerful method for mechanistic analysis. Such studies enable chemists to understand several reaction features, optimize reaction conditions and yield, develop cost-effective synthetic methodologies, and predict

Regeneration evolved in anamniotes in relation to metamorphosis: indications for attempts to induce limb regeneration in humans

The amazing capability of anamniotes, amphibians and fish, to regenerate limbs, tails, spinal cord, eyes, intestine, heart etc. contrasts with loss of organ regeneration in amniotes: reptiles, birds and mammals. Studies generally neglect to consider the life

Seaweed growing skyward with state-of-the-art green photobioreactor technology

Seaweed or marine macroalgae are renowned globally for applications spanning from functional food, animal feed, commodity chemicals and biofuels. Owing to its huge commercial demand, need for intensive seaweed farming has been rising over the decade. The

A single yoga video helps you de-stress and be confident

The practice of yoga has become very popular, being thought to improve people’s mental and physical health. There is a lot of scientific evidence pointing to the benefits of such mind-body practice – especially in the treatment

Evolution and adaptive value of yeast epigenetic memory of previous growth in galactose

Cellular adaptation to environmental changes often entails transcriptional responses that promote survival and proliferation. In certain cases, “memory” of previous experiences promotes a much faster transcriptional response upon second exposure to the same stimuli, leading to faster

Diving into the mucus – PEG micelles for oral delivery

Swallowing a pill of paracetamol for headache is fast and easy. The drug can be administrated at a desired time and location without any pain or assistance. Such is not the case for biological drugs like insulin,

A powerful tool for the study of CD4 T cells in malaria

Although aimed at controlling invading pathogens, immune responses can sometimes be harmful to the host. Responses against the blood stage of malaria are an example of this: while B cells are activated and produce useful antibodies that

Why iron and copper may be harmful to the aging brain

Similar to other organs, brain function declines with age. Furthermore, age is the single greatest risk factor for Alzheimer’s disease as well as other neurodegenerative diseases. Both iron and copper increase in the brain with aging and

Profiling biologics in circulating human whole blood

Functional and safety assessments of biologics prior to first-in-human (FIH) is key to understand the mode-of-action and safety profile. We have made use of an ex-vivo whole blood assay for its potential in assessment of antibody-based drug

DIY materials will allow scientists and engineers to re-make the world

Human development has been based on making the best possible use of natural materials and resources – initially plants, wood, stone and metals, before the evolution of man-made materials such as plastics. All of these kinds of