Category Archives: Research

Conditioning the brain immune system through physical activity

Staying physically active is one of the most beneficial things that a person can do for maintaining whole-body health. It is well understood that physical activity is important for building muscle, improving cardiovascular health, and boosting metabolism.

AB0 blood groups, von Willebrand factor and osteoprotegerin

The clinical importance of AB0 blood groups extends beyond the direct implications on transfusion and organ-transplantation compatibility. The role of AB0 blood group antigens in the pathogenesis of atherosclerosis, peripheral vascular diseases, thromboembolic-, cerebrovascular ischemic events, myocardial

Dental and temporomandibular joint pathology of the walrus

Maxillae and/or mandibles of 76 walruses (Odobenus rosmarus) housed in the Museum of the North, University of Alaska, Fairbanks were examined macroscopically according to predefined criteria. The museum specimens were acquired between 1932 and 2014. Forty-five specimens

Vistafin and endothelial progenitor cell dysfunction in diabetes mellitus

The prevalence of type 2 diabetes mellitus (T2DM) has been increased over recent decades, reaching worldwide epidemic. T2DM continues to exhibit a substantial impact on global health and requires increased expenditures of economic resources and medical care,

Epileptic encephalopathies in children: Animal models may change the word “catastrophic” to “hopeful”

Seizures are a sign of brain dysfunction caused by abnormal, hyperexcitable brain circuits. Clinical seizures range from brief staring spells to massive whole – body convulsions. The developing brain is especially prone to seizures and seizure-related brain

Gangliocytomas of the seller region: present and future

Gangliocytomas are well-differentiated tumors formed by irregular groups of large multipolar neurons, often with atypical characteristics. They are benign tumors and a complete tumor resection is considered curative. Their localization in the sellar region is extremely rare

How Americans remember and forget the U.S presidents

Groups of people remember and forget events that occurred in the past, just as individual people remember and forget events occurring in their lifetimes. The study of the memories of a group is called collective memory, and

Adolescent exposure of MDMA potentiates one of the hallmarks of Alzheimer’s disease

3,4 Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative widely consumed by adolescents, which has been described that produces oxidative stress in neurons such as dopaminergic neurons. Moreover, many patients with Alzheimer’s disease develop extrapyramidal symptoms due to alterations

Autism training: the one-eyed wo/man in the land of the blind

The number of people diagnosed with autism is on the rise. According to figures revealed in the Millennium Cohort Study (n= 13,287 families), autism prevalence rates in the United Kingdom (UK) are 3.5% of 11-year-old children. In

The use of bone marrow-derived mononuclear cells ameliorates airway inflammation in horses with recurrent airway obstruction

Horses stabled indoors live in a pro-allergenic environment and are exposed to molds, mites, and bacterial endotoxins from hay and bedding. This exposure exacerbates recurrent airway obstruction (RAO), an asthma-like disease. Affected horses suffer from recurrence of

Making 8-membered rings – It’s a DOS (diversity orientated synthesis) approach

For many years, the primary method of global drug discovery has involved the synthesis of naturally occurring molecules and their derivatives. This drug discovery process would involve several steps, from initial extraction and isolation from a biological

Mid ventricular ballooning in takotsubo cardiomyopathy: from a concealed to a manifest form

Myocardial bridging occurs when one of the coronary arteries (left anterior descending coronary artery, cicumflex artery and right coronary artery) tunnels through the myocardium rather than resting on top of it. Typically, the arteries rest on top of the heart muscle and

To get your target compound quickly with the TLC-based GUESS working chart

Choosing a suitable solvent system for a counter-current chromatography separation presents a challenge for many researchers. In this study we introduce a quick method of separating a target compound from the bark of Zanthoxylum myriacanthum var. pubescens

Type I interferons fuel adipose inflammation in obesity

When people get fat the visceral adipose tissue (VAT), fatty deposits inside the body that cling around the internal organs, get inflamed. This chronic low grade inflammation is termed metaflammation. Metaflammation has been found to contribute to

Prostate-specific antigen 1.5: The new screening protocol

Prostate cancer is the leading cause of cancer-related death in American men. Tragically, once the disease is spread beyond the prostate gland, therapies become very limited and survival is poor. Like other cancers, prostate cancer can recur

Unusual structure of aggregates formed by the fragment of Аβ(16-25) peptide

By the moment, a large number of proteins and peptides, polymerization of which in fibril formations leads to emergence of different diseases (amyloidosis), have been identified. But it is not always that fibril formations are toxic for