Category Archives: Research

Does statins increase risk of diabetes?

Statins are drugs that inhibit the enzyme 3-Hydroxy-3-methylglutaryl-coenzymeA (HMG-CoA) which is critical in the production of cholesterol molecules. Thus is commonly used in the treatment of abnormally elevated cholesterol which is known to contribute to cardiovascular disease

3MST produces redox regulators Cys-SSH and GSSH as well as signaling molecules H2S and H2Sn

3-Mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT) produces hydrogen sulfide (H2S), a well-known toxic gas, from L-cysteine. 3MST also produces H2S from D-cysteine in concert with D-amino acid oxidase (DAO). Cystathionine β–synthase (CBS) and cystathionine γ–lyase

Heavy metal resistant–plant growth promoting bacteria as an alternative strategy for decreasing accumulation of metals in plant tissues

In the present era, pollution of water, soil and air with heavy metals is increasing rapidly. Industrialization and technological advancement have caused serious damage to the ecosystem by releasing large quantities of heavy metals (i.e., cadmium, chromium,

Proline analogues present anti-Trypanosoma cruzi activity through inhibition of proline transporter

Trypanosoma cruzi is the protozoan parasite that causes Chagas disease, an illness that affects approximately 7 million people in Latin America. Nowadays there are only two drugs approved for Chagas treatment, benznidazole and nifurtimox. Both drugs were

Synthesis of industrial relevant ZSM-5 supported nano-sized metallic cobalt catalyst

Most chemical reaction of industrial relevance are catalysed by different metals in their metallic state. However, after catalyst synthesis which involves calcination to adequately anchor those active metals unto the catalyst supports, the metals were oxidized, thus

Activation by inhibition

Phosphorylation of proteins is one of the most important mechanisms through which protein function is quickly and reversibly regulated. Prototypically, an extracellular ligand binds to its cognate receptor(s) on the surface of a target cell, leading to

Dyspepsia – common; many causes, few cures

Dyspepsia (which literally means “bad digestion”) or as, it is commonly referred to in the English language, indigestion, is an umbrella term used to encompass a number of symptoms thought to originate from the upper gastrointestinal tract.

Discriminating live and dead sperm in ecotoxicology

Reproductive toxicity is an emerging topic in Ecotoxicology aimed to evaluate adverse impact of environmental stressors to reproductive systems and processes. Sexual reproduction is the complex process that marks the creation of a new individual of the

Why deaf identity matters

Deaf people have long protested against a disability view of deafness as an impairment that should be cured, and argued for Deaf culture as a unique culture and for sign languages as unique languages. Parallel to the

A turn of the head can cause a stroke

The major arteries of the neck cumulatively constitute the cervical arteries. They are highly important because they are the blood supply for the brain. There are four major cervical arteries: the right and left carotid arteries and

HDAC inhibitors: a new promise for anti-aging

Epigenetic modifications provide a mechanism of heritable but reversible changes in gene function that occur without the change in the primary DNA sequence due to alterations in chromatin structure. The global changes in chromatin structure and certain

Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases

The main role of the immune system is to protect the body from a wide range of foreign invaders. In some cases, the immune system recognizes a part of the body as “foreign” and starts to attack

Back to the future: Italian folk remedies to heal headache (XIX-XX century)

According to the World Health Organization, headache is, nowadays, among most common disorder of nervous system, resulting in serious problems and disability, but it is reasonable to state headache has existed as long as humankind. The purpose

How well do parents understand sexualised behaviour in their children?

While school-based programs are commonly used to help children protect themselves from sexual abuse, these programs tend to rely on children themselves to prevent and report sexual abuse. This asks much (perhaps too much) of the child.

mRNA Interactome Capture: a frontier method to discover mRNA-bound proteomes in plants

Cells are the structural and functional basic units of a given organism to support its life. The phenotype of an organism is highly determined by proteins at the molecular level in each cell. Imbalance of gene expression

Nischarin regulates energy metabolism

Nischarin is a novel protein that is discovered by us. We demonstrated that it functions as a molecular scaffold that holds and interacts with several protein partners in a number of biological processes. Previously we have shown