Category Archives: Research

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are

A new class of antisense RNAs that regulate gene expression

Cellular senescence is characterized by a stable cell proliferation arrest in response to different stresses such as oncogene activation. It is thus considered as a major anti-cancer barrier. However, the accumulation of senescent cells can lead to

Midkine controls natural bypass growth by regulating the bioavailability of VEGF

Cardiovascular occlusive diseases such as stroke, myocardial infarction or perivascular artery diseases (PAD) are a major personal and social burden. According to the World Health Organization, vascular occlusive diseases are the leading cause of death worldwide.  Current

Immunological changes at puberty drive increased mortality from endotoxemia in mice

Sepsis is a complex and deadly syndrome in which the body’s response to infection malfunctions and loses the ability to resolve inflammation properly. This loss manifests in a variety of ways, ranging from organ-damaging inflammation to immune

A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS

Hereditary hemochromatosis (HH) is the most frequent genetic disorder in Caucasians, which affects about 1 in 1000 people in the Northern European ancestry. It is an iron overload disease with typical clinical symptoms resulting from excess body

Molecular motion of propane in silica pores: computer simulations compared with neutron scattering experiments

Understanding how fluids, and notably hydrocarbon gases, seep through porous rocks in the terrestrial environment is essential to understand the fundamental processes involved and also to aid better recovery of these gases from the earth. It is

Myocardial stunning

How dose myocardial infarction develop? The myocardium is nourished from blood flowing in coronary arteries. When a coronary artery is abruptly occluded by a thrombus which develop at the site of a ruptured plaque or endothelial erosion,

Using glowing yeast to keep food safe

Dioxins and dioxin-like chemicals (DLCs) are a problematic group of pollutants that come from both natural and man-made origins. They do not easily break down on their own, which means that once they are present in an

How to detect dying neurons in the central nervous system?

The central nervous system (CNS) changes dynamically throughout an animal life. In the fruit fly, Drosophila melanogaster, asymmetric mitosis of the neuroblasts during embryonic development produces about 10,000 differentiated neurons that form a juvenile (larva) CNS. These

Sequencing of mtDNA of multiple single mitochondrion isolated from live cells identifies common heteroplasmic sites

Mitochondria are organelles present in all eukaryotic cells, including brain cells, and supply ATP required for cellular physiology through a series of redox reactions known as oxidative phosphorylation. They are unique in their requirement for expression of

Spindle associated membrane protein 1 (Samp1) in muscle differentiation

Skeletal muscles, the most common type of muscle in the body, are responsible for voluntary movements. Skeletal muscles are formed in a process called myogenesis (differentiation of muscles). During myogenesis a single-nucleus-myoblast (undifferentiated muscle cell) fuses with

Cholesterol manipulation switches the production of “toxic Aβ” to “protective Aβ”

The amyloid hypothesis maintains that the pathogenesis of Alzheimer’s disease (AD) is driven by the production and accumulation of amyloid-β (Aβ) peptides in the brain. Consequently, many therapeutic strategies to reduce Aβ production have been examined. However,

Polarized light therapy: Illuminating immunity

What is it?: Light has been used as an alternative mode for the treatment of diseases, since the ancient Egyptians basked in the sun to restore their energy. Phototherapies are modern treatments in which light is used

A new strategy against cancer cells. Targeting the Rho-GTPases interactions: The case of the new compound 1A116

For the last decades scientist have been working hard to find cancer´s Achilles heel to design and develop more specific and efficacious therapeutic strategies for cancer. It has become clear that altered cell signaling is a key

Estimating effects of new psychoactive substances (NPS) based on in vitro neurotoxicity data

The use of new psychoactive substances (NPS) is increasing and currently > 600 NPS have been reported. However, limited information on neuropharmacological and toxicological effects of NPS is available, hampering risk characterization. We reviewed the literature on

Bioartificial liver constructs

The liver with high regenerative capability performs a complex array of synthetic, metabolic, immunologic and detoxification functions to regulate the physiological homeostasis of the human body. Viral infections, drug induced liver injury, hepatocellular carcinoma, autoimmune disorders, alcoholic

The antibiotics of tomorrow: from enzyme Lego blocks to customized enzybiotics

Antibiotics play a key role in the treatment of bacterial infections and have saved millions of lives since their invention. Moreover, they allowed the development of complex surgeries and cancer treatments. However, already in 1945, after receiving

The role of oxidative stress in Type 2 diabetes

Type 2 diabetes is a major health concern that affects people no matter their gender, race, or socio-economic background is. In type 2 diabetes, a person’s body stops responding efficiently to insulin after a meal. This desensitization

Impact of digestion on the transport of macromolecule loaded nanoemulsion through intestine epithelium

The oral route, being the most convenient route for patients, has been extensively explored for the delivery of large molecular weight hydrophilic drugs. Oral delivery of macromolecules such as peptides and proteins has been a challenge due

Origin and fate of radionuclides in Swiss soils

Soils profiles from protected recharge fields used for drinking water production were drilled and analysed for radionuclides, such as radiocesium (137Cs), radiostrontium (90Sr) and plutonium (239+240Pu). Inventories and distribution of the radionuclides were compared with an uncultivated