Category Archives: Research

IL-2/IL-3 interplay mediates growth of CD25(+) acute myeloid leukemia cells

acute myeloid leukemia cells

A variety of cytokines regulate the survival, growth, differentiation and apoptosis of leukemia cells. Accordingly, aberrant or excessive expression of their receptors may be associated with the biological activity of leukemia cells, and hence with the outcome

Detecting math ability with brain potentials

Detecting math ability with brain potentials

It is known that the various individuals differ in their ability to perform arithmetic calculations. Some people can find mathematics an extremely easy exercise while for others it can become an insurmountable problem. For example, a significant

Our biological clock controls mitochondrial activity in a tissue-dependent manner

The molecular circadian clock and tissue-specific clocks

Mitochondria are the cell organelles that are responsible for the largest part of cellular energy production. Within these organelles both the tricarboxylic acid cycle (TCA cycle) and oxidative phosphorylation (OXPHOS) are taking place. In these cycles ATP,

Coastal wetland plant responses to elevated carbon dioxide

saltmarsh, coastal wetlands, nitrogen uptake, carbon dioxide

Coastal wetlands are some of the most efficient habitats globally when it comes to assimilating carbon dioxide from the atmosphere and storing it in soil. This is mainly due to the fact that many coastal wetland plant

The immunomodulatory enzyme IDO: Expression in the uterus of mares?

Detection of IDO protein in the equine endometrium by immunohistochemistry

IDO modulates immune responses. The enzyme indoleamine 2,3-dioxygenase 1 (IDO) degrades tryptophan. This amino acid is required for immune defences against pathogens, but also stimulates pathogen growth. Its degradation inhibits effector lymphocytes and retards pathogen proliferation. Thus,

Fine needle aspiration cytology for neck masses in childhood. An important tool in pediatrics

Mucin-secreting vacuolated cells, intermediate cells, and squamous cells

Neck masses can be incidental or the reason for significant concern for parents and physicians. The technique of fine-needle aspiration (FNA) cytology (FNAC) may be crucial in such settings. In 1981, the first FNA biopsy performed in

Cellular stress and AMPK activators including metformin and the anesthetic drug propofol promote restoration of human consciousness

Cellular stress and AMPK activators including Metformin

The neural mechanisms that give rise to human consciousness have been described as one of the greatest and most profound mysteries in all of modern medicine. The use of general anesthetics to induce loss of consciousness (LOC)

Keeping a clean house to suppress HER2+ breast tumor growth

Keeping a clean house to suppress HER2+ breast tumor growth

Autophagy (self-eating) is a process used by normal cells to keep a “clean house”. It degrades abnormal or damaged proteins and organelles, helps to fight infections and also provides energy during periods of fasting or exercise. Besides

The nature of bel-1 attC stabilizes its genetic environment and contributes to antibiotic resistance spreading

Schematic representation of integrons containing the blaBEL-1 gene

The rapid emergence of antibiotic resistance is a worldwide crisis, endangering the efficacy of antibiotic treatment. Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising

Fiber refractometry revisited

Response of three sensors across three different RI Zones.

The refractive index (RI) n of a substance is generally defined as the ratio of the speed of an electromagnetic wave in vacuum c to its velocity in that substance v, or n = c/v. Refractive index

Magnetic NPs for automatic speciation analysis of inorganic arsenic in environmental water samples

Magnetic NPs for automatic speciation analysis

Arsenic is a ubiquitous element in the environment originated from natural sources as well as human activities. This element has been identified as a public health problem because it has serious toxic effects even at low exposure

Sliding esophagoplasty. Can esophagectomy be avoided in esophageal obstruction due to huge thoracic aortic aneurysm?

Thoracic aortic aneurysm is a serious vascular disease which usually requires surgical aortic graft replacement. In recent years, endovascular stent placement proved a mini-invasive alternative to be used safely in properly selected instances particularly in subjects considered

Biologically active chemicals in yellow-cedar protect tree tissues and possibly human health

Nootkatone, a biologically active oxygenated sesquiterpene in yellow-cedar heartwood

Yellow-cedar trees, also known as Callitropsis nootkatensis, can live for hundreds of years because they have has few insect or pathogen pests. Periodic studies over the last century have examined extractable chemicals in their tissues and discovered

Is the gravimetric water content true? NIR spectroscopy gives an answer for polymers and composites

The more water is inside the polymer, the more intense the peak.

A common way to measure water content is by weighting the polymer or a composite sample, using a gravimetric method. This method often overlooks that there is already some water inside the initial (mistakenly called “dry”) material.

Non-invasive prenatal testing – safer or simply more profitable?

Map of Europe

Non-invasive prenatal testing (NIPT) is growing more and more popularand is advertised worldwide by dozens of companies as a safer alternative to invasive testing. In most countries it is paid for privately by the patient. But its

Behind the journey to spawn of European eels: expression and role of adrenergic receptors during silvering

Adrenergic receptors

Eels make an astonishing journey to spawn, migrating from Europe to the Sargasso Sea, near Bermuda, and back again. After spawning, larvae are transported by the Gulf Stream to the continental shelf of Europe and North Africa,

Climate change and the unfeasibility of United Nations Sustainable Development Goals

Climate change and the unfeasibility

With recent upward trends in global temperatures and sea levels, many countries are experiencing higher rates of evapotranspiration, groundwater depletion, water salinity, and loss of habitats.  Moreover, increases in living standards entail higher consumption of animal products

Inhibitors of intracellular enzymes for treatment of multiple sclerosis

The protein kinase inhibitor imatinib

Lymphocytes are white blood cells that are central in the immune response to foreign microorganisms. Like all cells, lymphocytes have a membrane, a lipid bilayer, that envelops the content of the cell. Proteins attached to the cell

Finding the beta-beta residue pairing for protein structure prediction

protein structure prediction

Prediction of the tertiary structure of proteins from their amino acid sequences is of great importance and of urgent demand in structural bioinformatics and biophysics, especially considering the increasing gap between the numbers of sequences and structures

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease

Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million