Category Archives: Research

Osteoarthritis of the wrist: Improved understanding of wrist movements leads to novel advancement in wrist replacement surgery

Like every other joint in the body covered by cartilage, the wrist can develop osteoarthritis. Many treatments have been attempted including cutting sensory nerves to relieve pain, stiffen the wrist, partially removing some of the joint and,

Colorectal cancer and enteric neurons: Should tumors be nervous?

Colorectal cancer (CRC) is one of the most frequent types of cancer in the world and is associated with a high mortality rate with over 700.000 deaths per year. Throughout the past decades, the development of CRC

Progressive multifocal leukoencephalopathy in idiopathic CD4 lymphocytopenia

Progressive multifocal leukoencephalopathy (PML) is a life-threatening demyelinating disease of the central nervous system caused by reactivation of the virus JC (JCV). This condition is triggered by immunosuppression, most frequently associated with AIDS, lymphoprolioferative diseases or immunosuppressive

Bimetallic nanoparticles-based biosensor for managing diabetes

The glycated hemoglobin test gives the information about average level of blood sugar over the past 2 to 3 months. It’s also called HbA1c, glycated hemoglobin test, and glycohemoglobin. Persons who have diabetes require this test regularly

Iodinated trihalomethanes in waters: a new class of toxic disinfection by-products

Disinfection of water supplies started in the early 1900s to reduce risks to public health from pathogenic microorganisms. Chlorination is the most common disinfection practice, achieving effective primary disinfection and sufficient disinfection residual in drinking water distribution.

We are all different. Even when we look at saliva!

Saliva has increasingly been used as a diagnostic fluid since it is easier to collect and process than blood and it has similar diagnostic capabilities. Total protein profiles can be obtained from saliva by capillary electrophoresis and

Post trauma: to filter or not to filter

Pulmonary embolism (PE) remains a significant cause of death in trauma patients. However, this patient population is also at risk of ongoing bleeding, making anticoagulation (Heparin, Coumadin, etc.) impractical. This puts trauma surgeons and vascular surgeons alike

Zebrafish is an attractive model to anticipate drug-induced renal injury in humans

Most of the innovative drugs with important therapeutic benefits are not approved or are removed from the clinical practice due to drug-induced toxicity. The kidneys are one of the most important target organs of drug toxicity because

Bioinformatics solutions for big data analysis in life sciences presented by the German network for bioinformatics infrastructure

Over the last decade, the amount of data generated by life science research has grown at a rapid rate and an increased complexity rendering the tasks of data analysis, management, and storage a unique challenge. To meet

Acridone-pyrimidine hybrid molecules: potential anticancer agents

Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.

Role of lymphadenectomy in non-small cell lung cancer surgical management

The prognosis and survival of non-small cell lung cancer (NSCLC) patients is dependent on the stage of disease, which is based on tumor size and nodal and distant metastasis at presentation. In turn, cancer stage assessment is

Role of the gut in systemic inflammation

The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly

An in-silico meta-analysis of cell-type-specific non-CpG methylation

Nowadays, the amount of raw data required for a genome-wide analysis is quite large and it is often difficult for even its original author(s) to spend enough time for its thorough analysis. Further, it would be practically

Unknown sonochemistry

The chemical effects of ultrasound, named sonochemistry, are known since 1927.  Today, there is a consensus within the scientific community that sonochemistry arises from the violent collapse of microbubbles formed in liquids submitted to power ultrasonic waves.

High-accuracy and high-sensitivity optical tracing of dinitrogen pentoxide (N2O5) involved in a nocturnal tropospheric chemical reaction process in smog chamber using quantum cascade laser

Dinitrogen pentoxide (N2O5) is an important reactive intermediate in the atmospheric chemistry of nitrogen oxides and nitrate aerosol, especially during night-time. It is also an important reservoir of NO3 radical that can react with various volatile organic