Category Archives: Research

Heat, diet and lifestyles control longevity in animals and man

Heat, Diet and Lifestyles control Longevity in Animals and Man

The inactivation of the heat shock gene called Sirtuin 1 (Sirt 1) is associated with many chronic diseases such as diabetes, non alcoholic fatty liver disease (NAFLD), cardiovascular disease and neurodegenerative diseases. Factors such as body temperature

Control of doping in racing pigeons

Pigeon racing is considered a popular sport in several countries such as Belgium, England, Netherlands, Portugal, Japan, Taiwan and South Africa. In all these countries, pigeon racing is a federated sport and racings take place on a

Chemical toxicity study of some Algerian medicinal plants

About 65 to 80% of the world’s population use traditional medicine for their primary health WHO according to the WHO report. However, the use of herbal medicines has come under scrutiny due to their perceived long-term toxicity

Molecular targeted therapy in alveolar soft part sarcoma

Molecular Targeted Therapy in Alveolar Soft Part Sarcoma

Alveolar soft part sarcoma is a malignant and rare tumor that includes about 1% of all STS (soft tissue sarcoma), and usually occurs in adolescents and young adults. This type of cancer has tendency toward distant metastasis

Can tree rings be used as pollution bioindicator archives to reconstruct past environments?

Heavy metal contents in wound and bark

Trace heavy metal (HM) pollution over time and space is becoming a growing global problem, as many studies have confirmed that human activities have dramatically increased natural concentrations of metal pollutants in the last century. HM are

Development of the Japanese version of the Kinesthetic and Visual Imagery Questionnaire (KVIQ)

Internal consistency of the KVIQ-20/KVIQ-10

Motor imagery is commonly defined as the mental simulation of one’s own performance without any associated overt movement (Jeannerod M, et al. Behav Brain Sci. 1994). Previous studies have suggested that motor imagery increases motor skill acquisition

Rethinking drugs’ development in acute heart failure?

The ten drugs developed in AHF during the last two decades

Acute heart failure (AHF) affects 1-2% of adults in developed countries. It strikes mainly people above the age 60, peeking in those older than 85 (prevalence ~ 17.4%). AHF is a life threatening medical event, with gradual

Strategies to enhance antioxidant potential and biosynthesis of essential oils in Ajuga bracteosa

Strategies to enhance antioxidant potential

Essential oils are the plant-derived natural products and are called “essential” due to the essence of the distinctive fragrance they contain, specific to the fragrance of the respective plant from which they are derived. A large portion

Evolution of the art and science of kidney transplantation in HIV positive patients

Evolution of the Art and Science of Kidney Transplantation in HIV

Once considered prohibitive, kidney transplantation in HIV (+) recipients is achieving outcomes similar to comparable recipients without HIV. These successes are possible because of incremental improvements in care that resulted from lessons learned from the last two

Early – life seizures: alarm bell for often severe clinical outcome

EEG during sleep showing Burst-suppression pattern in 3 months infant with Ohtahara syndrome.

Early life seizures (ELS) are a not uncommon clinical manifestations in infancy affecting from 1.8 to 3.5/1000 live birth. In infancy with rare exception of seizures typically benign  which include the Benign Familiar Neonatal Epilepsy (BFNE), Febrile

Engineering long-wavelength light-driven ion channels to hear the light

Artificial stimulation of the cochlea.

Optogenetics enables the remote control of neuronal activity by light. This is accomplished by channelrhodopsins, light-sensitive molecular switches, which are integrated into the neurons by adeno-associated viruses (AAVs)as gene ferries. AAVs are convenient and safe for gene

A new immune signature in people with Polycythemia vera: a modulator of disease progress?

A new immune signature in people with Polycythemia vera: modulator of disease progress

Polycythemia Vera (PV) is a disease in which your body makes too many red blood cells (RBC), whose main function is to transport oxygen from the lungs to all parts of your body. The many circulating RBC

Rethinking how we pay for conserving global biodiversity

Rethinking How We Pay for Conserving Global Biodiversity

In our article in Science, “How to pay for saving biodiversity”, my co-authors and I argue that it is time to rethink the global approach to saving the world’s remaining biodiversity and habitats. Twenty-five years after establishing

The pitfalls of PGT-A and scoring of mosaic embryos

The pitfalls of PGT-A and scoring of mosaic embryos

Preimplantation genetic testing for aneuploidies (PGT-A) or formerly known as preimplantation genetic screening (PGS), is genetic testing for numerical (aneuploidy) and structural chromosomal aberrations in IVF-embryos. Most aneuploidies including several structural chromosomal aberrations are not compatible with

Hearing loss in autoimmune disorders

Hearing Loss in Autoimmune Disorders

Autoimmune sensorineural hearing loss (SNHL) is a rare clinical entity accounting for less than 1% of all cases of hearing loss; however, this could be an underestimation based on the absence of specific diagnostic tests and the

Mitochondrial Complex I activity signals antioxidant response through ERK5

Mitochondrial Complex I activity signal

The vast majority of eukaryotic cells perform oxidative phosphorylation (OXPHOS), which uses the energy released by the mitochondrial oxidation of certain metabolites, i.e. glucose, to produce adenosine triphosphate (ATP). OXPHOS is highly efficient in energy production but

Adult-onset biotinidase deficiency

Adult-onset Biotinidase deficiency

Biotinidase is the enzyme that recycles the water-soluble vitamin, biotin, which is the coenzyme for four carboxylases that are involved in gluconeogenesis, fatty acid synthesis, and in the catabolism of several branch-chain amino acids. Biotinidase deficiency (BD)

Immunogenicity and safety of the new inactivated quadrivalent influenza vaccine Vaxigrip Tetra

Fig. 1. High-risk groups for influenza and flu–related complications

Influenza represents an acute viral respiratory disease caused by RNA-enveloped viruses. They belong to the Orthomyxoviridae family which comprises five genera, but only two (influenza A and B viruses) are of medical relevance in humans. Even though

In defense of Lady Windermere Syndrome

In Defense of Lady Windermere Syndrome

The eponym, Lady Windermere Syndrome (LWS), designates a disorder, exclusive to older women who are free of a predisposing lung disorder, caused by Mycobacterium avium-intracellulare and characterized by disease limited to the lingula and/or the middle lobe

The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma

The voltage-gated potassium channel, Kv1.3, at the crossroads of glial functions in glioma

Glioblastoma multiforme (GBM) is one of the most lethal cancers in adult humans, with a frequency of 6:100.000 people. Despite the current three-modality therapy, which includes surgery, radiation and chemotherapy, the clinical outcome of GBM patients remains