Category Archives: Research

Organic synthesis provides 17,18-EpETE and isoleukotoxin diol in optically active forms

The epoxide ring opening of the trimethylsilyl substituted epoxy alcohol 1 (R1 = H) by CH3S(O)CH2Na (NaDMSO) produces anion 2 as the transient species, which undergoes an unusual reaction rather than the Peterson olefination (Fig. 1). When

Achieving synergistic biopolymer functions using systems chemistry

Biology succeeds by maintaining intricate networks of chemical and structural information far from equilibrium. The guiding premise of the highlighted manuscript1 asks whether synthetic and materials chemistry will be able to achieve a bottom-up construction of alternative

Amniotic membranes can ease the eye pain

The cornea is one of the most innervated tissues in the body. When the corneal nerves undergo damage from various causes (such as refractory dry eye, corneal burns and infections, refractive surgery, among others), abnormal nerve regeneration

How a cellular samurai may be linked to autism

Inside cells, a highly dynamic and ever-changing cytoskeleton network determines cell shape (permanent or temporary), powers movement (intracellularly or on a substrate), aids cell division and segregation of chromosomes in daughter cells, and supports cellular extensions like

Focal epilepsy in four generations of a 19th century family

Two main types of epileptic seizure disorder have been recognised for more than half a century. Generalised seizures begin in central areas of the brain and produce immediate loss of consciousness, sometimes with bilateral jerking or widespread

Glycans to reprogram the immune response

Glycans are structures composed of sugars or carbohydrates, which are highly abundant on all cells. These molecules serve many functions, including binding and communication between cells, movement of cells and maintenance of tissue structure. Glycans are crucial

Calf hemodialysate: nutritive value plus placebo effect

Highly purified calf hemodialysate (HPCH), known as Actovegin or Solcoseryl, has been proposed as a medication for certain neurological and other diseases. For example, Actovegin was reported to have beneficial effects on cognitive performance in patients with

Stem cells accept the degradation products of Poly (ε-caprolactone)

One of the serious health issues experiencing by humans in the world are accidental injuries and associated complications. Treatment strategies for these injuries are depending on their severity and age of the person gets injured. Among this,

The role of genetic polymorphisms as biomarkers for HCC risk in Caucasian population

Hepatocellular carcinoma (HCC) is a frequent malignancy in many regions of the world, and the second leading cause of cancer-related deaths. Incidence and mortality are dramatically increasing in USA and Europe. The major risk factors for HCC

Uremia. A history of urine in the blood

The term uremia was first introduced in 1847; literally translated, it means “urine in the blood.” Today, uremia describes the myriad of symptoms and organ derangements that result from the failure of the kidneys in its normal

Patient safety ward round checklist via an electronic app

Patient safety is the tentpole around which modern healthcare is built. Though awareness of shortcomings in safety checks in the medical community is growing, implementing systematic approaches similar to those utilized in other high reliability industries is

Endothelial stiffening: a new parameter of endothelial damage in athero-susceptible regions of aorta

Atherosclerotic plaques that clog major arteries and lead to heart attacks and strokes are known to develop in sites exposed to non-unidirectional disturbed flow, such as bends and branches, whereas arterial segments that are straight and exposed

Anti-tubercular peptides: Future puissant weapon for tuberculosis therapy

Tuberculosis (TB) is one of the oldest and deadliest airborne asymptomatic tropical diseases in the world, caused by M. tuberculosis (Mtb), infecting one third of the global populace. At present, the emergence of multidrug-resistant tuberculosis and extensively

When the immune system is away, biliary cancer cells may come back to play

Tumours of the biliary tract (BTC) develop from the epithelium of bile ducts located inside and outside the liver and in the gallbladder. Surgery is the only curative treatment available. However, tumours often come back after surgery

Does body mass index affect how well patients do after meniscus surgery?

Obesity is present in about 38% of adults in the United States, and as many as 67% of patients with knee injuries (including meniscus tears). Some research has shown that obese patients have worse function and more

Angiotensin II actions on distal regulatory elements promote vascular dysfunction and hypertension

Cardiovascular diseases such as hypertension (high blood pressure) and atherosclerosis (blocked blood vessels) lead to heart attacks and strokes, and are highly prevalent worldwide. Furthermore, these complications are significantly accelerated in patients with diabetes. Angiotensin II (AngII)

New approach for CO2 reduction

Research converting carbon oxide (CO2) into low-molecular-weight organic compounds is extremely important because this research can not only reduce the concentration of CO2 in the atmosphere but can also convert CO2 into useful organic compounds. And, no

A new drug to improve drug-eluting stents in coronary artery disease

Patients with symptomatic coronary artery disease often receive stent treatment in obstructed coronary arteries of the heart. Even though current generation drug-eluting stents perform very well in the short-term, concerns still exist about their long-term efficacy due

Fasting blood glucose and prostate cancer: A meta-analysis of dose-response

Prostate cancer (PCa) is the most common cancer, and third leading cause of cancer deaths, in American men. So far, only a few well-established risk factors, including ageing and being racially black, are thought to be associated

Spontaneous neonatal renal vein thromboses. Which ones should be treated?

Neonatal renal vein thrombosis (RVT) is a well-known condition, the treatment of which suffers from the lack of codified protocols as consequence of absent consensual guidelines. With an incidence rate between 1.3 to 2.2 cases per 100.000