Category Archives: Research

Repelling water and dirt: superhydrophobic biological surfaces and biomimetic innovations

Life evolved over the last 3.5 billion years: a continuous process of mutation and selection – or trial and error. Today we know of some 1.8 million different species – but assessments indicate the existence of over

Cerebellar and brainstem malformations

The development of the cerebellum and brainstem is a highly complex process that involves a large number of genes. Mutations in these genes may cause an abnormal development of the cerebellum and brainstem and result in several

Trends in population characteristics, 30-day outcomes and one-year survival in patients treated with TAVI

Since the first-in-man transcatheter aortic valve implantation (TAVI) performed in our center in 2002, this technique has been increasingly accepted by the medical community as a viable and established option in patients with severe aortic stenosis (AS)

Medical students’ communication is trainable

A good physician-patient-relationship is essential for the patient’s health. Accordingly, the therapeutic relationship can influence the success of the therapy with a variance of 30%. A well-structured, patient-centred medical history taking enables an earlier and more accurate

New chemistry of aryl(2,2,2-trifluoroethyl)iodonium triflates

Fluorine-containing organic compounds have found wide applications in the areas of chemistry, biology, and materials science over the past several decades. Since only a few naturally-occurring organofluorides have been discovered, fluorinated organic compounds including CF3CH2-substituted compounds have

Easy assessment of the vascular autonomic function

Blood vessels change their diameter to keep a stable blood flow. The diameter of the peripheral arteries is determined by contraction or relaxation of the vascular smooth muscle, by endothelium-dependent and autonomic nerve-dependent mechanisms. Vascular endothelial cells

What about noninvasive prenatal testing (NIPT) from ‘cell-free fetal DNA’ (cffDNA)?

To know anything about the unborn human life was pure science fiction until the end of the 1950s. However today, prenatal diagnostics is routine, and many different approaches are available to check out the health of a

A new enhanced antibiotic treatment for early and late syphilis

Despite an effective treatment for syphilis is available since the penicillin introduction in the mid-20th century, this disease is still a global health concern with over 12 million new cases occurring each year worldwide. Recently, we have

Immobilization of bilirubin oxidase on graphene oxide for oxygen reduction – when the charge matters

In recent years knowledge from nanotechnology, biotechnology and electrochemistry helped to develop extremely interesting devices – biofuel cells. In such devices, many different biomolecules have been employed for biologically catalyzed energy harvesting from energy rich organic molecules.

Towards developing an ultimate optical method for bacteria detection

Microorganism detection is an essential task for wide range areas of human activities driven by economic and healthcare factors. Total Viable Count (TVC) method is a benchmark in microbiology, which is based on visual observation of the

Personality and alcohol use disorders outcome

The main objective of Alcohol Use Disorders (AUD) treatment is to give up alcohol drinking for as long as possible, and, secondly, to reduce physical harm by drinking less alcohol. However, there are two important problems which

Mapping the magnetic domain imaging for nano-magnetic films using novel MFM tips

MFM is an extended measurement function of the tapping-mode scanning and lift-mode controlling modes of atomic force microscopy (AFM), where the magnetic domain image is obtained by detection of magnetic force gradient changes between a magnetic tip

A 10 km intense run increases the number of cells in blood responsible for vascular repair

Exercise can cause a wide number of things to happen within our body. Our heart rate increases, our blood vessels dilate, we oxidise more fat and carbohydrate, and we can actively stimulate the repair of our own

4-PBA improves lithium-induced diuresis by attenuating ER stress

The Kidney regulates body water and sodium balance. The kidney produces approximately 180L of primary glomerular filtrate per day in a healthy adult. The major­ity of this filtrate is reabsorbed in the segments of kidney through water

Tay Sachs in South Italy

Tay Sachs disease (TSD) is an autosomal recessive neurological disorder characterized by significant deficiency of lysosomal enzyme β-Hexosaminidase A and subsequent intralysosomal accumulation of GM2 ganglioside. The classical TSD occurs in early infancy with psychomotor retardation, blindness,

Identification of a new T cell regulator

T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)