Category Archives: Research

Go with the flow: Studying the movement of T-cells to sites of inflammation

Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining

Acting in mechanisms of aging to delay/prevent Alzheimer’s disease

Alzheimer’s disease (AD), a severely debilitating and ultimately fatal brain disorder, affects millions worldwide. To date, clinical efforts to find a cure or adequate treatment have met with dispiriting failure. The disease is now on an ominous

How does your brain control interference from irrelevant information?

Given the continuous flux of visual information that competes for our attention in the everyday world, some form of attentional selection is needed to allow us to focus on what is relevant and ignore distracting information. This

New findings with therapeutic benefit in organ transplantation

Knowledge of the molecular mechanisms of cell death and understanding their fundamental role in a wide range of human diseases including myocardial infarction, stroke, sepsis, neurodegeneration, cancer, and organ graft ischemia-reperfusion injury, among others, is of major

What is a SERM and how does it work?

Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They

A new approach to improving the nutritional profile of fats in food products

Solids fats such as butter, shortening, or hydrogenated vegetable oils are a ubiquitous component of foods which contain a significant portion of liquid oil structured by a high-melting fraction, or “hardstock”. Fats contribute to many of the

Biodegradable microparticles used to prolong drug release to inhibit inflammation in osteoarthritis

Articular cartilage is located on the surfaces of the bones in the synovial joint. It protects the underlying bones from damage and shock, but also functions as a lubricant for frictionless movements of the human body. Damage

Prolactin regulates neurovascular coupling in male psychotic patients

Recent studies indicated that increased prolactin levels have negative effects on cognitive function in non-psychiatric populations and impair processing speed in patients with psychosis. According to the basic research, prolactin induces regional vasoconstriction via the inhibition of

‘DNA Fossils’, ancient mtDNA preserved in the nuclear genome: witnesses of human evolution milestones

Fragments of mitochondrial DNA (mtDNA) are known to get inserted into the DNA of the cell nucleus (i.e., our main genome) and to form NUMTs, i.e. dysfunctional sequences, nuclear pseudogenes of the mtDNA. Hundreds of NUMTs have

Human protein phosphatases: Proteomic insights

Protein phosphorylation-dephosphorylation, carried-out by kinase and phosphatases respectively, serves as major regulatory switch for controlling nearly all signaling processes. So far, the kinases remained a centerpiece in driving the functional response to signaling changes. However, more recently,

When the butterflies in the stomach prevail over the rationality: the case of alexithymia in intertemporal decision making

We are frequently faced with choices differing in the timing of their consequences, also called intertemporal choices. An example might be the following: should I spend my money now in an expensive holiday or put it into

The looming peril of neglected indigenous arbovirus infections to population expansion in Northern Australia

Viruses that are transmitted between vertebrate hosts by biting, blood-feeding arthropods (principally mosquitoes and ticks but also sandflies and midges) are called arthropod-borne viruses or, for short, arboviruses. The transmission of arboviruses to humans poses a significant and

CMR in pediatric HOCM: correlation with LV function, echocardiography and demographic parameters

Hypertrophic cardiomyopathy (HCM) is the most common inheritable cardiac disorder, with an estimated prevalence of 1:500. Although the disease is compatible with normal life expectancy, it is associated with premature death from ventricular arrhythmia, heart failure, and

Lessons from the Global Fund’s fight against AIDS, Tuberculosis and Malaria

At the beginning of this century, developing countries – particularly in Africa – experienced rapidly rising illness and death from AIDS, Tuberculosis, and Malaria. The three diseases caused massive suffering and economic damage. Treatment and interventions to

Transmitted sound wave mammography

This study was designed to look at a new type of totally harmless breast imaging called whole-breast transmission ultrasound to see if it could do something mammography cannot do – that is to diagnose the presence of

The eye gets stronger after seeing the world in chaos

Resembling the fact that some people are left-handed while some are right-handed, our two eyes are not functioning equally. Usually, our brain has a preference to the input signals from one of the two eyes, which is