Category Archives: Research

The cation channel of sperm modulates boar sperm motility during capacitation

The male gamete, the spermatozoon, is a highly specialized cell with a trimmed shape, far from the original cells of origin in the testicles. Their primary function is to deliver the paternal gene component of the new

Optimization of fracture healing by improved stabilization

Millions of fractures occur every year worldwide. Most of them heal uneventfully but 5-10 % show delayed healing or non-union. This leads to a great burden for the patients and high economic load for the healthcare system.

Confabulation: What is associated with its rise and fall? A study in brain injury

Confabulation is a relatively rare but debilitating memory disorder. It affects mainly (but not exclusively) brain injury survivors. Patients with confabulations have false memories, for example believing something happened to them which never in fact took place,

What can computational tools tell us about one of the non-structural proteins on Zika virus?

Zika virus has come to global attention even when it only causes mild symptoms to none. Then, why WHO declared a global emergency in 2016? Beside the rapid expansion of the outbreak through Asia and Latin America,

Chirality-induced spin polarization places symmetry constraints on biomolecular interactions

The work examines the fundamental relationship between an electron’s spin and a molecule’s chiral symmetry.  The spin of an electron is a pure quantum mechanical property and specifies its intrinsic angular momentum. A common classical analogy for

New Zealand blackcurrant benefits resting cardiovascular function in trained cyclists – dose responses

Fruit and vegetable intake is known to promote health benefits. In part, this can be attributable to the polyphenol content. Anthocyanins are a type of polyphenol and are known to promote health benefits, including positive cardiovascular alterations

Micelle catalyzed 4-nitrophenol reduction

In aqueous solution, molecules with both polar head group and non polar tail (amphiphilic molecules) aggregate i.e., micelles. They absorb/uptake both polar and non polar molecules from solution as a universal host. Thus the horizon of catalysis, detergency,

Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?

Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which

Strain-specific growth of gut microbiota modulated with carbohydrate-rich-diet is relevant to host health

A growing number of studies have revealed that reversal of intestinal microbial dysbiosis via dietary intervention provides promising benefits to our health. Manipulation of gut microbiota to achieve optimum health benefits is attractive but realizing it precisely

Spiders that pretend to be leaf veins

Daddy longlegs spiders (Pholcidae) are ubiquitous guests in houses around the world and thus known to most people. However, the bulk of the family’s currently 1,600 known species are confined to tropical forests, where they have evolved

Next generation nanomaterials with potential “track and kill”strategy against cancer

It is a paradox that cancer is by far the leading subject of research for scientists all over the world and still it remains to be the most dreadful disease to the mankind. A cancer patient’s treatment

Absolute configurations established for persistent organic pollutants DDT and DDD

Polychlorinated hydrocarbons such as hexachlorocyclohexane, hexachlorobenzene, heptachlor and chlorodane have long been known as effective and durable pesticides. Dichlorodiphenyltrichloroethane (or 1,1,1-trichloro-2,2-bis(chlorophenyl)ethane, DDT) has also been used widely and is still used in a few countries to control

Measuring small molecules for nutrition research?

Metabolomics is the study of small molecules that are present in biological samples. These small molecules include amino acids, fatty acids, organic acids and sugars, and are referred to as metabolites. These metabolites reflect the downstream activity

How plants transmit signals through alternate routes during stress conditions? CBL-CIPK mediated calcium signaling

One of the main characteristics of a plant life is sessile nature. Plants counter this frailty by evolving intricate and fast signaling system that can help in transferring stimuli at a very high rate. The phytohormone ABA

Understanding the mode of action of lynamicin D

Bisindolyl alkaloids represent a large family of natural products that exhibit potent and diverse biological activities such as anti-inflammatory, antimicrobial, antiviral and antitumor. Some of these secondary metabolites are currently evaluated in clinical trials for the treatment

Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of Alzheimer’s disease

Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and neurofibrillary tangles, which are composed of amyloid β-protein (Aβ) and phosphorylated tau proteins,