Category Archives: Research

Cells must communicate to maintain normal uterine and placental functions

Cell-cell communication through specialized channels known as gap junctions (Fig. 1) regulate cellular metabolism and coordinate cellular functions during growth and differentiation of organs and tissues. Gap junctions are composed of six proteins known as connexins (Cx)

Rain, rain go away, little amoebas want to race

Soil living amoeba Dictyostelium discoideum has been used as a leading model organism for studying eukaryotic cell differentiation and directional cell migration. These functions are interconnected: starved Dictyostelium cells form multicellular aggregates by directional cell migration, and

Altered expression of a protein in high vs. low spreading cancer cells

Breast cancer cells start off growing in the breast and end up spreading to the lung, liver, bones and brain. This spreading to another organ is called metastasis and is the major cause of patient death due

Calmodulin is necessary for vegetative growth, ultraviolet survival, and sexual development in the model filamentous fungus Neurospora crassa

Calcium (Ca2+) is an important player of intracellular signaling system in living organisms including fungi. In the model filamentous fungus Neurospora crassa, calmodulin (CaM) is a high affinity Ca2+-binding protein involved in the Ca2+ signaling process to

How to increase labor productivity of patients with AIDS in developing countries

Many patients with AIDS are receiving antiretroviral treatment via public programs especially in developing countries. Such programs are helpful for increasing the survival time of patients that in turn is beneficial for the well-being of their children.

Can a 6-monthly administered biologic prevent age-related blindness?

As increasing numbers of people survive in relatively good health to older ages, the importance of diseases impacting their quality of life rise in significance. One such disease is age-related macular degeneration, (AMD), which in the ‘wet

Chemokines, an answer to the gut inflammation?

Our gut is a complex organ which not only digests the food but also acts as an immune organ. The gut is lined by a single layer of specialized cells called as intestinal epithelial cells (IECs) which

FINDbase worldwide database for clinically relevant genomic variation allele frequencies

National and Ethnic Genomic Databases comprise a well-defined niche of genomic databases, aiming to record the prevalence of alleles, mainly pathogenic and of clinical relevance, but also benign, in different populations and ethnic groups worldwide in a

Electrically controlled insulin release

Stimuli responsive materials are promising for designing the next generation of drug delivery systems. Such materials would enable drugs to be released on-demand or in response to patient needs, specifically at the target site, minimizing side effects.

Aggregation Induced Emission tells us molecular aggregation processes

The aggregation-induced emission (AIE) is the phenomena that the fluorescence intensity is low in solution, the aggregated state shows strong emission. Conversion of the fluorescent properties depending on the aggregated states can also provide information on the

Noni leaf, black tea and Black cohosh encouraged bone growth in post-menopausal mammals

High intake of black tea and certain types of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture. Black tea consumption increased serum estradiol and prevented bone loss in

Emerging roles of cyclic nucleotide gated channels in plants

Plants are vulnerable to various biotic and abiotic stresses imposed in their respective growth environment. These stresses negatively affect the normal growth, development and productivity. Unlike animals, which can move to conditions conducive for growth and development;

Zooming in on the ‘big eaters’ in atherosclerosis: a key role for oxidation and cellular localization of fat

Our sedentary lifestyle combined with the enrichment of fat in our diet has led to an increase of diseases affecting the health of our cardiovascular system. Cardiovascular disease is one of the leading causes of death, with

Towards next-generation optimized personalized inhalers

Asthma is a chronic disease involving the airways in the lungs characterized by recurring attacks of panting and wheezing. Asthma affects about 300 million people and is a leading cause of hospitalization and ER costs for children

Erufosine increases RhoB expression in oral squamous carcinoma cells independent of its anticancer mechanism of action

Erufosine is an ether–lipid-derived synthetic compound belonging to the group of alkylphosphocholines (APCs). This chemotherapeutic agent exhibits pronounced anti-leukemic activity without affecting the normal hematopoiesis and exerts its influence by modulating signal transduction pathways in malignant tumor

A network of stuttering

Network science uses techniques from mathematics, computer science, and several other fields to study complex systems. Nodes are used to represent an individual in the system, and connections are placed between nodes that are related in some