Mapping red nucleus connections in humans by using dMRI and tractography

Human brain is an enormous and complex network. Central to current scenario on brain networks is the concept of the connectome More »

Curiosity and flexibility help birds to master rapid environmental change

Birds are one of the most mobile organisms on earth due to their ability to fly. This allows them to use areas far apart for breeding and non-breeding More »

Virus chainmail: protective and porous metal-organic framework grown on a virus

Biomineralization describes a process of programmable accumulation, concentration, and construction of inorganic ions regulated by organisms to form both amorphous More »

Species are always important

This review is based on the premise that all species are important to life on earth even if the exact role or value of a species has not been formally documented More »

 

Fibroblasts in rheumatoid arthritis: From friend to foe

Fibroblast effects on leukocytes

Our joints are composed of tissue-resident cells, called fibroblasts, which are responsible for maintaining the structure of the joint and repairing damaged tissue. Additionally, we and others have shown that fibroblasts can also influence the types and

TussisWatch: a smartphone system to identify cough episodes as early symptoms of chronic diseases

Variance Trends for Different Subsets and Two Levels of Validation

Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive diseases and often the terminal stage of heart and lung disease, leading to death and disability. Both of these diseases may manifest with similar conflicting

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

A culture medium for screening pandrug- resistance to aminoglycosides in Gram-negative bacteria

Multidrug resistance in Gram negatives is now recognized as an issue of worldwide interest. Those bacteria possess various resistance mechanisms compromising the efficacy of several class of antibiotics such as beta-lactams and aminoglycosides. Therefore, it is essential

Pathophysiological advantages derived from simultaneous measurement of diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO)

Schematic presentation of CO and NO transfer

It has been over 100 years since Marie Krogh developed the method to measure the transfer of carbon monoxide (CO) through the alveolar wall. Since then, the single-breath CO diffusing capacity (DLCO) has become the most clinically

Counting choline: why this nutrient is important and how we can measure it

Simplified schematic of our new colorimetric method for measuring choline and phosphocholine

Choline is an important nutrient for the growth and sustenance of living things, from humans to bacteria. Cells covert choline into phosphocholine via the activity of the enzyme choline kinase, and a change of other enzyme mediated

Sea-level rise: a big push to increase plant root zone’s subsurface water salinity level

Location of coastal east-central Florida

In coastal east-central Florida (ECF) in the U.S. (Fig. 1), plant root zone’s (PRZ) subsurface water salinity level is crucial to the survival of various vegetation species because it is one of the dominant factors controlling seed

How does chromium cause lung cancer? Resistance to cellular stress

How does chromium cause lung cancer

Lung cancer is the deadliest form of cancer in both men and women. One cause of lung cancer is occupational exposure to heavy metals. Extremely useful in several industries, heavy metals have become widespread environmental pollutants over

Second-generation composites from recycled wind turbine blades

Second-generation composites from recycled wind turbine blades

The demand for wind and other forms of clean energy is increasing in the US and throughout the world. Wind energy is also expected to provide 14.9% of the global electricity demand by 2020. Under this scenario,

Insights into the molecular basis of posterior polymorphous corneal dystrophy

Posterior polymorphous corneal dystrophy (PPCD) is a rare autosomal-dominant disease affecting the innermost part of the cornea, termed the endothelium. This monolayer of cells maintains corneal transparency by regulating its hydration. Human corneal endothelial cells do not normally

Large animal models for osteoporosis research: The small ruminants (sheep and goat)

Role of oestrogen in bone remodeling

In the healthy skeleton, constant bone remodeling occurs in which mature bone tissue is removed, in a process called resorption, and new tissue is formed in order to maintain bone strength and mineral homeostasis in continuum with

Metabolic and non-metabolic roles of pyruvate kinase M2 isoform in retinal rod photoreceptor cells

Pyruvate kinase M2 isoform regulates photoreceptor structure

Glucose is the main source of fuel for every living cell. Normal cells take up glucose and burn it in the mitochondria (oxidative phosphorylation) for energy production (ATP synthesis). Rapidly dividing cells, such as cancer cells, and

Advances in drug discovery and development in geriatric psychiatry

Drug discovery for disorders of the central nervous system is a long and challenging process, with a high attrition rate from the preclinical stages through to marketing a compound. In geriatric psychiatry, the heterogeneous nature of these

Chemotherapy and radiotherapy in abdominal sarcoma

Chemotherapy and Radiotherapy in Abdominal Sarcoma

Soft tissue sarcomas (STS) are a rare group of cancers that arise in connective tissues such as muscles, fat and blood vessels. STS can occur almost anywhere in the body but are most commonly found in the

Clostridioides difficile infections: what is new in laboratory diagnosis and clinical treatment

Clostridioides difficile infections (CDI) have become a major economic issue from developing countries as well as from the Western World. Early and accurate diagnosis of CDI allows earlier treatment, which can significantly reduce the morbidity, mortality, medical

The silent effects of heart surgery: voice and swallowing

Heart disease is a leading cause of death worldwide. Heart surgeries saves thousands of lives a year but can be lengthy and complex. During surgery, many patients require prolonged periods of intubation and coronary bypass (mechanical support

The destruction of endocrine disruptors in wastewater

In Canada, endocrine disruptors are a very topical issue in wastewater effluent quality. We define endocrine disruptors as chemicals that can interfere with the endocrine or hormone systems in wildlife and humans. Results can vary from different

Lernaean hydra puzzle in compensatory angiogenesis and tumor drug resistance

Diagrammatic representation of how compensatory angiogenic mechanisms are driven by redendent proangiogenic signalling

Before we proceed to apply the analogy of Lernaean hydra to compensatory angiogenesis and tumor drug resistance against anti-angiogenic drugs (AADs), let us have a cursory look at the interesting mythology of this hydra. According to Greek

Floating oils can be submerged in water with granular particles as encapsulated oil sacks

Formation of tightly packed encapsulation observed with both medium sand

The particle stabilized liquid interfaces in liquid droplets and encapsulation of liquids with nano particles are used in industrial applications such as ink jet for printing and fertilizers. Applications with much larger drops of hydrophobic liquids ranging

Genetics, human metabolism and non-alcoholic fatty liver disease

Relationship between genetype, phenothype and diet in the NAFLD context

Advancement in technology has introduced a new era of genetic investigation: the so called next-generation sequencing. This innovative approach has allowed to extend the study of our genome and has led to the identification of numerous variants