Tag Archives: 18-EpETE

Organic synthesis provides 17,18-EpETE and isoleukotoxin diol in optically active forms

The epoxide ring opening of the trimethylsilyl substituted epoxy alcohol 1 (R1 = H) by CH3S(O)CH2Na (NaDMSO) produces anion 2 as the transient species, which undergoes an unusual reaction rather than the Peterson olefination (Fig. 1). When