Tag Archives: alzheimer’s disease

Mapping brain shrinkage in dementia

Dementia is not a specific disease but rather an umbrella term for a collection of syndromes that affect thinking and behaviour. This is similar to cancer being the umbrella term for different cancer types, such as melanoma,

Sick arteries give their small cousins a beating: new insight into vascular pathology in Alzheimer’s disease

That the brain’s blood vessels, a.k.a. cerebrovasculature, play an important role in Alzheimer’s disease (AD) and related brain disorders is not entirely new. In fact, it was Alois Alzheimer and some of his contemporaries who observed gross

Vitamins and minerals in control of serious diseases?

We all know that vitamins and minerals are important, but why? The amino acid L-tryptophan is “essential” for mammals, and it must be obtained in the form of food. L-tryptophan can be utilized for protein synthesis, and

Self-reference effect on memory and well-being in patients at risk for Alzheimer’s disease

In cognitive psychology, the term self-reference effect (SRE) refers to the fact that individuals remember information better when the latter are related to themselves. This effect particularly boosts episodic memory, that is, the detailed memory of personal

Metabolic imaging is new a tool to investigate blood-brain barrier in Alzheimer disease

Alzheimer disease (AD) is the most common form of dementia worldwide. AD is characterized by progressive decline in cognitive functions. In the initial stages, deterioration of memory and loss of other intellectual abilities start to interfere with

Serotonergic drugs in the treatment of symptoms in Alzheimer’s disease

Alzheimer’s disease is a neurodegenerative disease showing alterations in neurotransmitters, above all in brain regions responsibles for cognition and emotions. In this disease, an imbalance between neurotransmitters, acetylcholine, GABA, glutamate, noradrenaline and serotonin are included. In brain

Melatonin and serotonin in psychiatric and brain disorders

Melatonin is well known as a treatment for jet lag, being naturally released by the brain when we close our eyes to go to sleep. However, recent research shows that melatonin is released by many, if not

How antioxidants may have a pro-oxidant effect?

The main function of the consumption of antioxidants is to strengthen the activity of enzymatic antioxidant systems of our cells and this is intended to prevent or delay oxidative stress caused by the increase of reactive oxygen

Novel presenilin 1 mutation in familial late-onset Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive dementia, affecting over 20 million people worldwide, mainly adult subjects in advanced age characterized by loss of neurons and the presence of amyloid plaques in the brain. Several families have been

Music therapy eases depression, soothes agitation in nursing home residents with dementia

Did you know that around the world there are more than 35 million people living with dementia? People who are diagnosed with dementia, a progressively worsening disorder that affects memory, often experience a sad mood, agitation, and

Endocrine regulation of Alzheimer’s disease. The Achilles heel of dementia and other neurological conditions

Alzheimer’s disease (AD) is the most common disorder of the central nervous system and the most frequent cause of devastating dementia in the elderly. Typified by loss of memory and by cognitive decline, AD lowers the quality

Innovative tool, promise for treating Alzheimer’s disease and other neurodegenerative brain diseases

If at the dawn of the twentieth century, Alzheimer’s disease was seen as a rare disease, but today the incidence of this disease has taken epidemic proportions and is treated as one of the diseases of civilization.

Lipids are major players in Alzheimer’s disease

Alzheimer’s disease is the most common neurodegenerative disorder affecting over 36 million people worldwide. Alzheimer’s patients suffer from dementia and memory loss and go through a progressive, irreversible and eventually fatal loss of cognitive functions. When Alois

Resting state fMRI analysis using sparse dictionary learning in SPM framework

Brain always be active even people are in rest. In the resting period, it has been observed that particular groups of brain region are always co-activated. These regions are functionally connected each other and each group is

A possible new treatment for Alzheimer’s disease and stroke using nanoparticles

Alzheimer’s disease (AD) and stroke are two neurological disorders that share the common feature of neuronal death. The peptide under investigation here is IRL-1620, which has been shown in previous studies to reverse neuronal death as well

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric

Alzheimer’s disease: SMILES to preserve wisdom

Simplified molecular input-line entry systems (SMILES) is informative representation of molecules. This representation gives possibility to compare molecules in their architecture and in their action. Molecules characterized by good pharmaceutical action can be modified in order to

The multiple faces of Alzheimer’s disease: it’s not only memory

When we think of Alzheimer’s, the first thing that comes to our mind is memory loss. Memory problems were, until recently, a core and mandatory criteria to diagnose Alzheimer’s disease. The word has spread through awareness programs

Human blood brain barriers malfunction in Alzheimer’s disease

While the ancient Greeks and Romans already associated old age with dementia, it was not until 1901 that the German psychiatrist Alois Alzheimer diagnosed the first case of Alzheimer’s disease in a fifty year old woman. Today,