Tag Archives: antibody

Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade

Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,

Who is the father of innate immunity?

The thermometer can show that something is wrong with a patient (pyrexia). But it cannot be more specific. Likewise, there is evidence, dating back to the ancient Greeks, that the slight changes in blood serum that occur

Immunogenicity of Virus Like Particles (VLP) with modified envelope (Env) protein

HIV uses a special strategy to evade the immune system during the course of infection in a human, based on features of envelope protein.  The HIV Env glycoprotein that forms spikes on the surface of virus particles

Specific synthetic nucleic acids instead antibodies

 For a long time immunological methods have been applied in biological research as well as for detection and evaluation of various substances in clinical analysis of body fluids. Serum proteins, antibodies, form integral parts in all variants

Bleeding and thrombosis in a patient with primary antiphospholipid syndrome using norethisterone

Antiphospholipid syndrome is an autoimmune hypercoagulable state caused by specific antibodies, and it is known to be associated with the occurrence of blood clots, or thrombosis, in the veins and/or arteries.  However bleeding is rarely associated with the syndrome. Only a few cases

Disguising insulin as an antibody: a Trojan horse for type 1 diabetes prevention

Type 1 Diabetes (T1D) is an auto-immune disease. These diseases appear when our own immune system, which normally protects us from foreign pathogens (viruses, bacteria,…), attacks our own cells. In the case of T1D, T lymphocytes, which

Improved antibody selection with assisting plasmid

When the human body is invaded by foreign molecules, the immune system will be activated to fight against these intruders. This is done with the help of antibodies which act as the defence force of our body.

Antibodies at your pipette tips

Antibodies are essential in our immune system to fight against all sorts of diseases that we could encounter every day. The technological developments over the decade has allowed scientist to isolate target or disease-specific antibodies in the

The thymus: a small organ with a mighty big function

The thymus lies in the chest behind the breastbone and above the heart. Relatively large in infancy, it increases in size until puberty and thereafter shrinks to only a few grams in old age. It consists of

Learning from evolution to target cancer with combinatorial strategies

Chemotherapy is the most prominently used therapy for many cancers yet it effects multiple and, in many cases, unknown targets. Of the most modern advancements in cancer treatment is the targeting of single key gene products, for

What type of immune responses are needed to control HIV infection?

Human immunodeficiency virus-1 (HIV-1) infection can be controlled by antiretroviral therapy (ART) for long periods of time, preventing the development of HIV-induced immunodeficiency and AIDS. However, HIV-1 infection cannot be eradicated from immune cells by ART and

Fully human anti-CAIX antibodies for RCC immunotherapy

Globally, there are roughly 270,000 new cases and 116,000 deaths attributed to kidney cancer occur each year. More than 90% of kidney neoplasms are classified as renal cell carcinoma (RCC), which accounts for 3% of all adult

Could cancer be cured by inducing an autoimmune disease against It?

Might there be some way to make a microbial protein that the immune system normally overlooks (a “non-antigen”) into a target for an active immune response (an “antigen”)? Could one co-opt the immune system to produce an

Characterizing the whac-a-mole concept of a bispecific antibody targeting cancer cells

One of the great promises of antibodies is to be magic bullets that specifically target diseased cells without affecting normal cells. Oncology researchers identify targets on tumor cells that are unique, overexpressed, or oncogenic drivers that can

A electrochemical biosensor for the detection of antibodies against avian influenza virus type H5N1 in hen sera

Avian influenza (AI) is a highly contagious disease caused by Orthomyxoviridae family viruses. Highly pathogenic avian influenza (HPAI) virus can be easily transmitted between poultry, leading to severe disease outbreaks or even pandemics. It is difficult to

Combining different antibody flavors to improve cancer therapy

Our immune system is specialized at identifying ‘foreign intruders’ (pathogens) or virus-infected cells inside the human body. This can be achieved by antibodies (immunoglobulins) that circulate in our body and are able to bind targets with high