Tag Archives: apoptosis

Targeted nanoparticles for molecular imaging

Oncologic, cardiovascular, and neurological diseases are the most common causes of death in the developed world. It is well established, especially for cancer that early diagnosis results in more favorable outcomes. Although various diagnostic tests are available

Vodka and wine consumption: good for your liver?

Approximately 50 million Americans are affected by metabolic syndrome. Metabolic syndrome is defined as hypercholesterolemia, hypertriglyceridemia, high blood pressure and glucose intolerance leading to type 2 diabetes mellitus. Patients with metabolic syndrome have an increased risk of

Lymphocytes T and Treg as prognostic factors of newly diagnosed DLBCL patients

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and most common form of non-Hodgkin lymphoma. The mechanism of DLBCL pathogenesis is not fully understood. Malignant B-cells responsible for lymphoma formation are believed to arise from different stages

Epithelial wound healing: a matter of life and death

Wound healing is a crucial property for the maintenance of the structural and functional integrity of an individual. In the whole organism it usually requires the participation of many cellular types. The fundamental aspects of wound healing,

MSX1 sensitises cells to ovarian cancer treatment

Ovarian cancer is an insidious disease which in the majority of cases is diagnosed only at a very late stage. The majority of ovarian tumours are of a particular aggressive type, called high grade serous ovarian cancer.

Aging is adaptive

Aging is a lifecycle stage common to all life forms and is observed in both unicellular and multicellular organisms. The primary manifestation of aging in unicellular organisms is replicative senescence.   As the cell ages, cell cycles become

Fluorescent carbon dots integrated hydrogels for lung cancer therapy

Cancer is considered as one of the leading cause of death worldwide. Due to the ever changing lifestyle of the modern society, the incidence of cancer is on the rise. Lung cancer is the most frequently diagnosed

Alternative splicing: the new frontier in diabetes research

The human genome is predicted to contain 22.000 coding genes, but more than 200.000 proteins are expressed in human cells. This discrepancy is explained at least in part by the presence of alternative splicing (AS), a key

Nitric oxide trigger apoptosis in the brains in Border Disease

Border disease is a pestivirus infection accompanied by central nervous system (CNS) and skeletal abnormalities in sheep and goats. Affected fetuses and newborn animals exhibit brain disorders. This study investigated the relationship between the severity of the

More reasons to appreciate the Golden Spice “saffron”

Cancer remains a leading cause of morbidity and death worldwide. What is even worse is that the number of new cancer cases is projected to massive increase which would probably make it the first cause of death

ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration

Neurons, the major component of our brain, have long processes (called “axons” and “dendrites”) to communicate with other neurons and cells. In many brain diseases that old people get suffered from, such as Alzheimer’s disease, Parkinson’s disease,

Small-molecule RETRA is effective against a fatal childhood cancer

The bone tumor Ewing’s sarcoma is one of the most aggressive cancers in childhood and adolescence. Before the era of chemotherapy, more than 90% of Ewing’s sarcoma patients succumbed to their disease. With the introduction of intensive

Small or big, brain cells don’t like protein gunk that lead to diseases like Alzheimer’s, Parkinson’s and Huntington’s

An interdisiciplinary study by scientists at Trinity College Dublin (TCD, Ireland) have answered a hotly debated question in the neurodegenerative diseases research area: “Which protein aggregate form is the primary pathogenic agent in neurodegenerative diseases – (i) the prefibrillar oligomeric

A combination therapy to induce apoptosis in difficult-to-treat cancer cells

The presence of activated PI3K-AKT is a major obstacle to successful chemotherapies. Since PI3K-AKT is activated in many healthy tissues, chemical inhibitors of PI3K-AKT inevitably have many unwanted side effects. By using a cholesterol-targeting drug called beta-cyclodextrin

New effective treatments for Alzheimer and Parkinson’s disease

Alzheimer and Parkinson’s disease are the most common neurodegenerative disorders. As people are getting older than in previous generations, the number of people who are affected has increased. Unfortunately, there is no cure for these diseases. The

Phospholipase A2 group IVc blocks mammary tumor apoptosis

The Hirosaki hairless rat (HHR) is a mutant rat strain with autosomal recessive inheritance spontaneously derived from the Sprague-Dawley rat (SDR). The hairless phenotype of HHRs is due to the deletion of basic hair keratin genes, and