Tag Archives: atherosclerosis

L-arginine and B vitamins improve endothelial function in subjects with mild to moderate blood pressure elevation

Mediated by nitric oxide (NO), intact endothelial cells control vascular homoeostasis by regulating vascular tone and preventing smooth muscle cell proliferation, monocyte adhesion to the endothelium and platelet aggregation, thereby protecting blood vessels from the formation of

Zooming in on the ‘big eaters’ in atherosclerosis: a key role for oxidation and cellular localization of fat

Our sedentary lifestyle combined with the enrichment of fat in our diet has led to an increase of diseases affecting the health of our cardiovascular system. Cardiovascular disease is one of the leading causes of death, with

p38α MAP kinase inhibition in atherosclerosis – a new therapeutic tool?

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Selective recruitment of monocytes into the arterial intima and their transformation into macrophage-derived foam cells is one of the earliest events in the pathogenesis of atherosclerosis. Foam

Small dense LDL, sub-clinical atherosclerosis and psoriatic arthritis

Psoriatic arthritis (PsA) is a chronic arthropathy associated with psoriasis, marked by an axial and/or peripheral joint involvement and high cardiovascular. Several large  studies confirmed the relationship of small dense LDL (sd-LDL) with coronary events. Although some

Family, cholesterol and the genes from the ground up or why screening matters

In 1913, the “cholesterol theory” of atherogenesis was proposed. In the 1930s a genetic disorder, familial hypercholesterolemia (FH), which is associated with elevated levels of low-density lipoprotein (LDL) cholesterol and high risk of heart attack at an

Aorta tertiary lymphoid organs: Powerhouses of B cell immunity in atherosclerosis

Cardiovascular disease (CVD) is the leading cause of death worldwide. Yet, our understanding of how the immune system impacts CVD is very limited and immune system-based therapeutic approaches are not in sight. Lymphocytes are major cellular constituents

Licorice Root enhance cardiovascular health

The increasing incidence of lifestyle-based conditions–most notably those conditions that impact cardiovascular health, obesity, and blood sugar–has compelled consumers to consider natural solutions for these challenges. According to the Centers for Disease Control and Prevention (CDC), cardiovascular

A better way to measure heart disease risk for an overweight society

Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup

Collateral damages and self-inflicted scars by inflammation in cardiovascular diseases

Inflammation is a double-edged sword used by the body to initiate the healing process. However, persistence of immune responses can cause progressive destruction of tissues culminating in self-destructive autoimmune reactions which is a hallmark of many diseases. 

The history of carotid stroke

Carotid artery disease is a condition in which fatty deposition (plaque) within the vessel wall of one or both neck arteries causes progressive vascular narrowing. Plaque surface rupture leads to a shower of debris to the brain,

Erasing atherosclerosis with nanoparticles and near-infrared laser

The advent of nanomedicine and near-infrared (NIR) optics allows the development and design of tools that enhance diagnosis and treatment of atherosclerosis. Clinical application of these technologies is anticipated in the near future. Our trial called NANOM-FIM

Development of anti-atherosclerotic drugs on the basis of cell models or how to make the elderly pay for placebos

The large research series has become internationally known in 1986 after a publication by the ex-Soviet minister of health as the first author and continues until today. In brief, cell cultures have been used for evaluation of

Researchers describe “imm-unifying theory” capable of explaining multiple medical problems

About a year ago, investigators at the Shock Trauma Center in Baltimore, MD found that patients who had organ transplants fared quite well after traumatic events. The authors of the manuscript, which was published in the Journal