Tag Archives: bone

Cortical bone: a ground-breaking source for multipotent stem cells

Multipotent stromal cells also known as mesenchymal stem cells (MSCs) are a family of cells derived from the mesodermal germ layer, distinguished by their ability to replicate themselves and differentiate, or change morph into different types of

Building a matrix mediated cell expansion system for high-quality cartilage regeneration

Articular cartilage is a tissue found in joints throughout the body (knees, elbows, etc.) that plays a significant role in allowing the body to maintain proper movement and engage in physical activities; it also supports the transfer

Improvement of critically sized bone fracture healing by using conductive tissue engineering scaffolds

Bone is the second most prevalent transplant tissue after blood. Healing the critically sized bone defects caused by tumor or trauma are among the major challenges for orthopedic surgeons. Although, allografts and autografts are commonly used for

Ability of four vitamin D assays to measure vitamin D2

Vitamin D, the sunshine hormone, is essential for healthy bones.   Vitamin D is found in two basic forms in nature—vitamin D3 which is made by skin exposed to sun rays (cholecaliferol), and vitamin D2 which is made

Small-molecule RETRA is effective against a fatal childhood cancer

The bone tumor Ewing’s sarcoma is one of the most aggressive cancers in childhood and adolescence. Before the era of chemotherapy, more than 90% of Ewing’s sarcoma patients succumbed to their disease. With the introduction of intensive

Bone marrow transplantation resets the clock in patients with Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia (CLL) accounts for about one third of all of leukemias. In the United States 15,000 patients are diagnosed with and 4,500 patients die of CLL every year.  CLL is a diverse disease. Some patients

Radiation therapy for nerve pain when cancer spreads to bones

One of the hallmarks of cancer is its ability to spread from the primary site of origin to other places in the body.  Such secondary sites are called “metastases”.  One of the commonest sites for cancer secondaries

Bone cells prefer to grow on aligned fibers

The finding of suitable biomaterials allowing the bone restoration of large bone defects is the subject of active research. Non-resorbable biomaterials such as polymers can constitute suitable scaffolds allowing the deposition of new bone. Microfibers made with

The influence of pollution on bone premature aging: the case of the fishbone

Bone is one of the most sophisticated biological structures developed by nature, its major constituent is a calcium phosphate mineral that is similar, in composition and structure, to minerals within the apatite group which are naturally formed

Elastic properties of the annular ligament of the human stapes

Stapes – the smallest bone in the human body. It is located in the middle-ear. It constantly vibrates transferring sound from the external word to the hearing organ. The vibrations are possible thanks to the extremely compliant

Development of amorphous magnesium-calcium phosphate as a bone substitute biomaterial

The research that we report here is related to amorphous magnesium-calcium phosphate (AMCP) materials. The word “amorphous” is of latin origin; “a” means no and “morphous” means shape. The amorphous materials do not have the well-behaved periodic

The amount of impaction and loss of reduction in osteoporotic proximal humeral fractures after surgery

More than 90% of proximal humerus fractures affect the elderly. Thus, we should understand that these are osteoporotic fractures. We can imagine the proximal humerus of the elderly as an egg shell, a broken egg shell. Fixation

A novel micro-injector for micro injection in dental application

Micro-injection technology is widely used in clinical surgery. Herein, periodontal disease is to be a starting point, we will develop a novel micro-injector carrying bone graft substitutes for repairing bone defect to minimizing the patient’s discomfort. Periodontal

Image processing as a facile method to determine pore size distribution in porous scaffold

Scaffold for tissue engineering are porous devices which allows the regeneration of living tissues such as bone, cartilage or other tissues. Some studies demonstrated that the regenerative properties of the scaffold are strongly dependent both on the

A key molecule for embryonic bone development is dysregulated in cancer

Bone is an endocrine organ with important biological functions. The skeleton produces hormones, such as FGF23 and osteocalcin, which regulate an extensive list of normal functions. Some of these functions include glucose metabolism, male fertility, blood cell

Granules of a bone substitute biomaterial have a 3D arrangement mimicking bone microarchitecture

Bone is a naturally rigid and porous tissue of the body. The pores allow the circulation of blood vessels and the creeping of bone-forming cells at the surface of the tissue. Bone loss can occur systemically, for