Tag Archives: breast cancer

Next generation sequencing, a new gold standard for clinical gene panel testing

The adaption of the Next Generation Sequencing ( NGS ) technology to clinical laboratories has revolutionized the molecular diagnostics by reducing the costs and increasing the throughput. Clinical use of NGS enables simultaneous testing of multiple genes

Let-7b expression in breast cancer: does have any implications on the DNA repair capacity?

Epigenetics study the changes on gene expression that occur without altering the primary structure of the DNA. Examples of epigenetic mechanisms that can produce such changes include microRNA ( miRNA ) silencing, DNA methylation, histone methylation, among

Teasing apart the roles that oncogenic miRNAs play in breast cancer

Oncogenic miRNA and breast cancer Since the early 2000’s, the field of RNA has been contributing to major discoveries in cancer research. McroRNAs are small RNA molecules (miRNA), inhibit the messenger RNAs that produce our proteins. Normally,

Radiation-induced morphea: an under-recognized complication of breast radiation

Worldwide, breast cancer was the most common new diagnosis and common cause of death in women in 2012. As screening for breast cancer has improved patients are often identified in the early stage of disease and are

An RNA degradative enzyme that stimulates breast cancer cells to move and invade

RNA degradative enzymes carry out key steps in regulating gene expression. They are broadly grouped into two groups; exonucleases, that degrade RNA from one end and endonucleases, which cut within the body of an RNA molecule. PMR1

Metabolic reprogramming: from estrogen dependence to self-sufficiency

Breast cancer is the most common cancer in women and, despite significant progress in diagnosis and treatments, incidence has been steadily increasing in the last 40 years. Approximately 70% of breast cancers are characterised by the expression

Discovery of potential anti-breast cancer agents dual targeting ER and VEGFR-2

Breast cancer (BC) is the most common cancer in females worldwide. Among all BC patients, more than 70% are diagnosed as estrogen receptor positive (ER+). Estrogen is the primary female hormone which is responsible for the development

Focusing on the most relevant gene variants in inherited breast and ovarian cancer

Modern sequencing technology (which has begun to become adopted in clinical labs) can provide invaluable genetic information of individuals, such as those with a family history of early onset breast cancer. However, this information also results in

Why women with early stage breast cancer don’t complete their chemotherapy treatment?

Breast cancer is a leading cause of cancer death among US women.  For women with early stage breast cancer (stages I and II), completing chemotherapy after surgery can increase survival.  Despite this proven benefit, some women do

FDG-PET/CT is accurate in diagnosing breast cancer recurrence

A woman with a substantial risk of breast cancer recurrence experiences worry and anxiety, and a correct diagnosis is relevant in order to make well-founded decision on treatment strategy. It is then crucial to provide accurate diagnostic

The synergistic role of prolactin and estrogen in breast cancer requires PAK1

In 2016, the American Cancer Society estimates about 40,000 deaths will result from breast cancer. This makes breast cancer the second leading cause of cancer-related among women. Despite the frightening statistics, the death rates from breast cancer

Androgen receptor; a tale of two cancers

Prostate cancer and breast cancer share similarities as hormone related cancers with a wide range of heterogeneous settings. Macklin, as early as 1954, provided evidence for a significantly higher frequency of prostate cancer among relatives of breast

Polyfunctional T cells induced potent anti-tumor efficacy

Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells.  In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within

A promising novel drug for breast cancer

The reason cancer is so difficult to treat is that cancer cells are our own cells running wild, which means that they generally do not make any protein or other molecule that normal cells don’t make.  This

Screening breast MRI in patients with personal history of breast cancer

This study looked at patients who had a personal history of breast cancer diagnosed at a premenopausal age to see if having screening breast MRI provided a benefit to the patient. Patients with a personal history of

Type of breast cancer provides clues to genetic susceptibility

Breast cancer is a common disease affecting 1 in 11 women in the UK but like many common cancers incidence increases with increasing age. Only 1 in 1,700 women younger than 30 and 1 in 228 women