Tag Archives: calcium

Calcium ion by replacing magnesium ion unravels an unexpected role for the mitochondrial F1FO-ATPase

The F1FO-ATPase/synthase is universally known as a complex enzyme machinery which, embedded by the FO portion in the inner mitochondrial membrane and the catalytic F1 sector protruding in the matrix, matches the transmembrane proton flux which occurs

Astroglial magnetic fields and cortical neuronal coupling

In recent years, it has been demonstrated an increasing role of astrocytes in information processing and cognitive functions, which depends on the close relationship between neurons and astrocytes into the cerebral cortex. The mammalian cerebral cortex is

How plants transmit signals through alternate routes during stress conditions? CBL-CIPK mediated calcium signaling

One of the main characteristics of a plant life is sessile nature. Plants counter this frailty by evolving intricate and fast signaling system that can help in transferring stimuli at a very high rate. The phytohormone ABA

Emerging roles of cyclic nucleotide gated channels in plants

Plants are vulnerable to various biotic and abiotic stresses imposed in their respective growth environment. These stresses negatively affect the normal growth, development and productivity. Unlike animals, which can move to conditions conducive for growth and development;

A messenger and its disciples: Spreading stress messages in plant through Ca2+-CBL-CIPK network

The early life forms appeared on earth as entities that were covered by cellular membranes. These entities had a major problem from one of the abundant elements present in the earth- Calcium (Ca2+). Higher level of Ca2+

Regulation of ER Ca2+ homeostasis by disulfide reductase

Intracellular calcium is one of the most important second messengers for the regulation of various cellular processes including protein secretion, muscle contraction, gene transcription, protein degradation and apoptosis. The endoplasmic reticulum (ER) is not only the organelle

Skin cells help to find new drugs for dying neurons

Huntington disease (HD) is an inherited disease that causes the progressive death of nerve cells in the brain structure. In mid ages this leads to several symptoms including uncontrolled twitching movements, called chorea, emotional problems, and loss

Theophylline, a drug to treat asthma increases risk of fracture and causes vitamin D deficiency

Incidence of chronic obstructive pulmonary diseases (COPD) of which asthma is the commonest manifestation is growing by leaps and bounds in two most populous countries, India and China due to rapid growth of industrialization and associated rise

Calcium disturbances in Parkinson’s disease

Parkinson’s disease is a common disorder of the brain that affects around 127,000 people in the UK alone. The disease is characterised by the loss of nerve cells (neurons) that control mobility. Symptoms include muscle stiffness, tremor

A new target in the fight against breast cancer

Cancer cells differ from normal cells in many ways, including their abnormal growth and their ability to change shape and migrate to other tissues. These differences are partly caused by changes in the production of proteins and

New insights in how nitrite can be involved in cardioprotection

Nitrite, an inorganic ion which abundantly occurs in green leaves and other vegetables, is known to help to prevent and counteract cardiovascular diseases, but the mechanisms involved are still partially unclear. In the attempt to cast light

Genetics and dietary stress explain low calcium absorption

It is well understood that osteoporosis is influenced by a variety of environmental factors such as age, nutrition, and race. Calcium absorption is one of these important factors and low levels of calcium absorption have been associated

The fertilization process: a new way to look at an old phenomenon

The union of the egg with the sperm at fertilization has fascinated many philosophers and scientists. Most of our knowledge on fertilization derives from studies on marine organisms that release eggs and spermatozoa into the sea water.

Heme: an old player with a novel mechanism in cardiac muscle contractility

Heme is a complex containing iron and protoporphyrin IX and it is commonly bound to proteins involved in oxygen transport, detoxification and energy production. However, this molecule has been known to have toxic effects in the heart.

Regucalcin may prevent the development of prostate age-related pathologies such as prostate cancer

Regucalcin (RGN) is a protein with a multifunctional role, which regulates the basic biological processes determining cell fate. RGN actions have been implicated in the control of intracellular calcium levels, oxidative stress, cell metabolism, cell death and

Granules of a bone substitute biomaterial have a 3D arrangement mimicking bone microarchitecture

Bone is a naturally rigid and porous tissue of the body. The pores allow the circulation of blood vessels and the creeping of bone-forming cells at the surface of the tissue. Bone loss can occur systemically, for