Tag Archives: cancer

A new strategy against cancer cells. Targeting the Rho-GTPases interactions: The case of the new compound 1A116

For the last decades scientist have been working hard to find cancer´s Achilles heel to design and develop more specific and efficacious therapeutic strategies for cancer. It has become clear that altered cell signaling is a key

Oncogenic role of CircPVT1 in head and neck squamous cell carcinoma

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs that have recently shown to behave as gene regulators in eukaryotic cells, extending our previous knowledge regarding the diversity and complexity of the transcriptome. Nowadays, circRNAs have

A new strategy to deliver anti-cancer nanodrugs and decrease their toxic side effects by temporarily blunting the RES uptake using Intralipid®

Nanodrugs, or nanotechnology-based therapeutics, show great promise for treating a number of diseases, including cancer. However, an analysis of the literature from the past 10 years finds that in studies of cancer nanodrugs, a very small fraction

Can we treat cancer by targeting Treg subset without causing autoimmune disease?

The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also

When the immune system is away, biliary cancer cells may come back to play

Tumours of the biliary tract (BTC) develop from the epithelium of bile ducts located inside and outside the liver and in the gallbladder. Surgery is the only curative treatment available. However, tumours often come back after surgery

Fasting blood glucose and prostate cancer: A meta-analysis of dose-response

Prostate cancer (PCa) is the most common cancer, and third leading cause of cancer deaths, in American men. So far, only a few well-established risk factors, including ageing and being racially black, are thought to be associated

Gamma-tubules — novel filaments in the fight against cancer

The word skeleton sounds very significant, and indeed humans could not exist without a skeleton! Similarly, a cellular skeleton or cytoskeleton is crucial for the functions of a cell. Several different types of cytoskeleton have been identified

A novel biomarker for oral cancer

Tongue squamous cell carcinoma (TSCC) is the most predominant form of oral cancer in developed countries with varying incidence in developing countries wherein diverse etiological factors such as chewing betel-quid comprising betel leaf, areca nut and slaked

Colorectal cancer and enteric neurons: Should tumors be nervous?

Colorectal cancer (CRC) is one of the most frequent types of cancer in the world and is associated with a high mortality rate with over 700.000 deaths per year. Throughout the past decades, the development of CRC

Acridone-pyrimidine hybrid molecules: potential anticancer agents

Cancer is one of the world’s most pressing challenge to research community and leading cause of death. As per the 13th report of American Science of Clinical Oncology, 14 million people are diagnosed with cancer every year.

Role of lymphadenectomy in non-small cell lung cancer surgical management

The prognosis and survival of non-small cell lung cancer (NSCLC) patients is dependent on the stage of disease, which is based on tumor size and nodal and distant metastasis at presentation. In turn, cancer stage assessment is

Multi-scale mechanical characterization of prostate cancer cell lines

Cellular mechanics are of prime importance in the birth and the evolution of tumors towards increasingly aggressive stages and are often proposed as potential biomarkers to evaluate metastatic potential. Mechanical properties of two human prostate cell lines,

The dichotomy of exosomes in cancer: targets and treatment vehicles

Exosomes are extracellular vesicles released by all cell types that mediate intercellular communication. Exosomes exist in healthy as well as pathological conditions, but it is in cancer research that they are gaining increasing attention. Exosomes released by

Curing glioblastoma with oncolytic virus and immune checkpoint blockade

Cancer immunotherapy utilizes the patient’s immune system to recognize and/or destroy tumors. The immune system has both positive activator/effector and negative inhibitory functions. Immune checkpoints are one such inhibitory function that can be overcome by immune checkpoint

Combining radiation with a PI3K/MTOR inhibitor

Patients with HPV-negative head and neck cancer (HNSCC) carry a poor prognosis despite optimal treatment with chemoradiation, with a 5 year survival of less than 50%. The future for this disease must lie in further escalation of

Lower TSH and higher free thyroxine predict incidence of prostate but not other common cancers

The pituitary gland signals production of thyroid hormones by the thyroid gland through secretion of thyrotropin (TSH). There are two types of thyroid hormones produced by the thyroid gland. These include thyroxine (T4) and tri-iodothyroinine (T3). These

Biomarker panel for detecting early pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is the fourth leading cause of cancer-related deaths in the USA. Most of the PDAC patients are diagnosed at an advanced stage of disease and their

PREMM: A mobile application to drive your own hereditary cancer prevention

In the recent publication, ‘Community Practice Implementation of a Self-administered Version of PREMM1,2,6 to Assess Risk for Lynch Syndrome’, Dr. Luba and colleagues at the Monterey Bay GI Consultants Medical Group in Monterey, California, present the use

Oxidative stress sensitivity of cancer cells could be altered by plasma membrane status

Oxidative stress is defined as “A status that the balance between the oxidation reaction and the antioxidant reaction is lost in our body, and that the oxidation state is dominant.” Oxidative stress is generally adverse for our

What is a SERM and how does it work?

Estrogen receptors (ERα and ERβ) are nuclear receptors that function as ligand-dependent transcription factors. They play a vital role in many physiological functions such as the development and differentiation of the reproductive tract and mammary gland. They