Tag Archives: cancer

Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types

Most cancers are driven by somatic mutations in proto-oncogenes and tumor suppressor genes. Genetic changes in a tumor may accumulate in the tissue self-renewal phase prior to neoplasm. The risk of sporadic mutations increases with age. In

Pancreatic cancer stem cells: fatty acid synthesis and mevalonate pathways are implicated in their survival

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high metastatic potential. The disease is the fourth leading cause of cancer-related deaths in the USA, and is projected to be the second one by 2030, due

New therapy for the treatment of childhood bone cancer

Cancer in children and young adults is rare, with survival rates being very high, mainly depending on the treatment. The biggest proportion of this diagnosis will be on leukaemia and brain tumours, with just about 3% of

International Conference on Oncology and Cancer Therapeutics. Chicago, Illinois, USA. October 30- November 01, 2017

Allied Academies invites all the participants from all over the world to attend “International Conference on Oncology and Cancer Therapeutics” held in Chicago, Illinois, USA at October 30- November 1, 2017 which includes prompt Keynote Presentations, Special

A novel mechanism by which viral integration drives cancer

Human papillomaviruses (HPV) are a group of about 200 DNA viruses that infect the skin, or the mucous membranes of the anus, genitals and oropharyngeal cavity. HPV infections are the most common sexually transmitted disease in the

Hospital readmission after head and neck microvascular reconstruction

Unplanned readmissions are associated with decreased healthcare quality and increased costs. This nationwide study examines causes for unplanned readmission among head and neck cancer patients undergoing immediate microsurgical reconstruction. Patients undergoing head and neck tumor resection with

Proteins regulate cancer cell attachment

Aggressive cancer cells are able to leave their original site and invade other tissues. In order for these cells to do this, they must have some way of moving around. This means that a cancer cell must

Prostate-specific antigen 1.5: The new screening protocol

Prostate cancer is the leading cause of cancer-related death in American men. Tragically, once the disease is spread beyond the prostate gland, therapies become very limited and survival is poor. Like other cancers, prostate cancer can recur

A new three-headed, long-tailed molecular beast eats cancer

We made and tested a series of new compounds containing three chemical rings and hooked them to long carbon tails. These new molecules killed a broad range of pediatric and adult cancer cells including neuroblastoma, osteosarcoma, malignant

Do all children have equal access to Phase I cancer trials?

Approximately 60% of pediatric cancer patients participate in clinical trials compared to only 5% of adult cancer patients.  These pediatric clinical trials have been instrumental in improving the 5-year survival rate of childhood and adolescent cancer patients

Identification of a new T cell regulator

T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)

Atomic structures of telomerase shed light into the mechanism of telomere replication

Telomeres comprise the six nucleotide repeats at the end of eukaryotic chromosomes and they are essential for the faithful replication and protection of our genome. Significant telomere attrition forces the cells to enter a dormant state to

Germ cell testicular cancer incidence

Testicular cancer is not your normal malignancy. A few cancers occur in children, while most occur in older people. However, hardly any occur specifically in young adults. Testicular cancer is one. Incidence rises rapidly in the teen

Annual Summit on Cell Signaling and Cancer Therapy. Chicago, USA. September 27-28, 2017

Annual Summit on Cell Signaling and Cancer Therapy is bustling to be held at Chicago, USA during September 27-28, 2017 hosted by Conferences Series. Through the theme “To Frame An Admiring Portal For Pioneering Cancer Therapy and

DNA methylation markers in colorectal cancer state-of-the-art

Colorectal is the fourth leading cause of cancer-related death worldwide. There were over 1.3 million new colorectal cancer cases worldwide, of which approximately 50% died as a result of the disease in 2012. Like all cancers, CRC

Drugs from the sea: complex structures to fight a complex problem of resistance in cancer

It is well known that incidence of cancer cases figures among the leading causes of morbidity and mortality. Most of disseminated cancers share the common feature of not responding to anticancer drugs. This phenomenon is known as