Tag Archives: cancer

Is chromatin remodeling required to modulate embryonic development?

Chromatin remodeling is active critical process during embryonic development and in cellular malignancies such as cancer. Chromatin is the highly condensed form by which the genomic material (DNA) is packaged in the cell nucleus. The fundamental subunit

Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies

Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the

The protein p62 helps liver cancer-initiating cells survive

The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or

Cancer can growth without angiogenesis. A new field opened in cancer biology

The word cancer derives from the Greek “karkinos “which means “crab”.  According to the legend reported by Paul of Aegina in the 7th Century AD, this name was chosen because this disease “has the veins stretched on

STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells

The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within

Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy

Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific

Novel Cancer Therapeutics Summit 2016

Organizer: GTCbio Start date: November 7th, 2016     End date: November 9th, 2016 We invite you to attend the 2016 Novel Cancer Therapeutics Summit, to be held on November 7-9, 2016 in San Francisco, CA. This summit includes

MTA3: A master coregulator of physiology and oncogenesis

The discovery of novel therapeutics for treatment of cancer is today’s prime concern due to abundantly increasing cancer drug resistance and deaths worldwide.  MTA3, a member of metastasis-associated protein (MTA) family, plays unique and collaborative roles in

Why is radiation treatment more effective for cancers caused by HPV?

Human papilloma virus (HPV) is the most common sexually transmitted infection in the United States and can lead to cancers in the affected organ such as the cervix. In the last 15 years, the rise in prevalence

Surprisingly diverse impacts of SMARCB1 loss on gene expression programs in a lethal pediatric cancer

Malignant rhabdoid tumors (MRTs) are aggressive childhood cancers that are often resistant to chemotherapies and spread to other areas in the body (metastasis), making them one of the most lethal solid cancers known. Primary MRTs are frequently

Is the best cancer offense a good defense?

Although the unique DiRas (Distinct subgroup of the Ras family) family of small GTPases shares homology with the pro-oncogenic Ras GTPases, it has tumor-suppressive actions. DiRas1 (also known as Di-Ras1 or Rig) has been reported to be

Long learning curve for surgeons operating on esophageal cancer

Esophageal cancer is the eighth most frequently diagnosed cancer worldwide and the sixth most common cause of cancer-related death. The curatively intended treatment usually includes extensive surgery with removal of most of the esophagus (food-pipe) and the

Who is a cancer survivor? A brief overview of this controversial term

Chiara Marzorati, Foundations of the Life Sciences Bioethics and Cognitive Sciences, European School of Molecular Medicine (SEMM), European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy. Gabriella Pravettoni, Department of Oncology and Hemato-oncology, University of Milan,

CCN proteins : A new vista for molecular medicine

The CCN family of proteins is composed of six members playing critical biological roles, both in normal and pathological conditions. The first three CCN proteins discovered were designated Cyr61, Ctgf, and Nov because of the context in

Improving cancer care: Counseling patients on quitting smoking

Given the damaging effects of continued smoking on cancer management and post-treatment survival, all oncology practitioners should provide brief counseling to patients who smoke, encouraging them to quit smoking and referring them to specialized care (i.e. tobacco

Orphans and inflammation

Many are now well-aware of the negative impact of inflammation on our health, including cancer as well as rheumatologic, metabolic and neurologic disorders.  Insults to the body either through injury (acute or chronic), or poor diet can