Tag Archives: cancer

Radiation-induced morphea: an under-recognized complication of breast radiation

Worldwide, breast cancer was the most common new diagnosis and common cause of death in women in 2012. As screening for breast cancer has improved patients are often identified in the early stage of disease and are

„Kill-ators” – fighting cancer with a claw

According to the WHO Cancer Report, cancer is the second most frequent cause of death in developed countries. In 2012 approximately 14 Mio people were diagnosed worldwide and more than 8 Mio people died from cancer. Despite

Hitting the sweet spot: Sialic acid sugars for the treatment of immune diseases and other disorders?

In addition to DNA, proteins and lipids, sugar molecules are essential building blocks for every living cell. There are many different types of sugar molecules in a cell which are linked to one another forming chain or

Is chromatin remodeling required to modulate embryonic development?

Chromatin remodeling is active critical process during embryonic development and in cellular malignancies such as cancer. Chromatin is the highly condensed form by which the genomic material (DNA) is packaged in the cell nucleus. The fundamental subunit

Microfluidic tumor models help pre-clinical screening of T cell cancer immunotherapies

Cancer immunotherapy draws upon the patient’s own immune system to recognize and fight the disease. One form of cancer immunotherapy is known as adoptive T cell therapy (ACT) consisting of isolation, genetic manipulation and reinfusion into the

The protein p62 helps liver cancer-initiating cells survive

The most common form of adult liver cancer is hepatocellular carcinoma (HCC), which is the third-leading cause of cancer deaths worldwide. HCC arises from persistent liver inflammation related to hepatitis B or C infection, alcohol consumption, or

Cancer can growth without angiogenesis. A new field opened in cancer biology

The word cancer derives from the Greek “karkinos “which means “crab”.  According to the legend reported by Paul of Aegina in the 7th Century AD, this name was chosen because this disease “has the veins stretched on

STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells

The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within

Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy

Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific

Novel Cancer Therapeutics Summit 2016

Organizer: GTCbio Start date: November 7th, 2016     End date: November 9th, 2016 We invite you to attend the 2016 Novel Cancer Therapeutics Summit, to be held on November 7-9, 2016 in San Francisco, CA. This summit includes

MTA3: A master coregulator of physiology and oncogenesis

The discovery of novel therapeutics for treatment of cancer is today’s prime concern due to abundantly increasing cancer drug resistance and deaths worldwide.  MTA3, a member of metastasis-associated protein (MTA) family, plays unique and collaborative roles in

Why is radiation treatment more effective for cancers caused by HPV?

Human papilloma virus (HPV) is the most common sexually transmitted infection in the United States and can lead to cancers in the affected organ such as the cervix. In the last 15 years, the rise in prevalence

Surprisingly diverse impacts of SMARCB1 loss on gene expression programs in a lethal pediatric cancer

Malignant rhabdoid tumors (MRTs) are aggressive childhood cancers that are often resistant to chemotherapies and spread to other areas in the body (metastasis), making them one of the most lethal solid cancers known. Primary MRTs are frequently

Is the best cancer offense a good defense?

Although the unique DiRas (Distinct subgroup of the Ras family) family of small GTPases shares homology with the pro-oncogenic Ras GTPases, it has tumor-suppressive actions. DiRas1 (also known as Di-Ras1 or Rig) has been reported to be

Long learning curve for surgeons operating on esophageal cancer

Esophageal cancer is the eighth most frequently diagnosed cancer worldwide and the sixth most common cause of cancer-related death. The curatively intended treatment usually includes extensive surgery with removal of most of the esophagus (food-pipe) and the

Who is a cancer survivor? A brief overview of this controversial term

Chiara Marzorati, Foundations of the Life Sciences Bioethics and Cognitive Sciences, European School of Molecular Medicine (SEMM), European Institute of Oncology, Via Adamello 16, 20139, Milan, Italy. Gabriella Pravettoni, Department of Oncology and Hemato-oncology, University of Milan,