Tag Archives: cardiovascular disease

Macrophages in atherosclerosis; the good, the bad and the foamy?

Atherosclerosis is a chronic inflammatory condition in which arteries are narrowed due to the deposition of plaque material to the artery walls. This narrowing can give rise to other cardiovascular events like thrombosis or a stroke. One

Absence of bilirubin increases oxidative stress in vivo

Oxidative stress, defined as an imbalance between oxidants and antioxidants in favor of the former, is a hallmark of many diseases, including cardiovascular disease (CVD) and related metabolic syndrome. Modifying uncontrolled oxidative stress may attenuate the development

Angiotensin II actions on distal regulatory elements promote vascular dysfunction and hypertension

Cardiovascular diseases such as hypertension (high blood pressure) and atherosclerosis (blocked blood vessels) lead to heart attacks and strokes, and are highly prevalent worldwide. Furthermore, these complications are significantly accelerated in patients with diabetes. Angiotensin II (AngII)

Statins and diabetes: do the benefits outweigh the risks?

Cardiovascular disease (heart attack and stroke) is the leading cause of death in the United States. Prescription cholesterol-lowering medications have been shown to lower the risks for heart attacks and stroke. In fact, roughly 28% of Americans

A better way to measure heart disease risk for an overweight society

Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup

Good morning… let the stress begin. What is stress and how do we study it?

The American Psychological Association estimates that more than 70% of Americans regularly experience the physiological or psychological symptoms associated with chronic stress, with a third of the population thought to be living with extreme levels of stress.

Can hypertension and related cardiovascular diseases be caused by Dark-Matter-like RNAs?

Hypertension is a common but one of the most important health problems, because it is a major risk factor for many cardiovascular diseases. Hypertension is a multi-factorial disease involving complex interplay of genetic and environmental factors. To treat

Putting mammalian target of rapamycin on track

Mammalian target of rapamycin (mTOR) is the target protein of rapamycin, a bacterial metabolite in Streptomyces hygroscopicus primarily found in the soil sample from Easter Island in South America thirty years ago. Since mTOR was discovered in

High prevalence of undertreated cardiovascular disease in patients diagnosed with cancer

Heart disease and cancer are the most common causes of death in the United States. They often have the same risk factors (for example, smoking, advancing age, obesity). Heart disease can worsen outcomes after cancer therapy and