Tag Archives: cardiovascular

p38α MAP kinase inhibition in atherosclerosis – a new therapeutic tool?

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Selective recruitment of monocytes into the arterial intima and their transformation into macrophage-derived foam cells is one of the earliest events in the pathogenesis of atherosclerosis. Foam

Egr-1, an inducible switch in the cardiovascular response to injury

The vascular system normally facilitates the passage of blood, nutrients and oxygen throughout the body whilst maintaining a non-thrombogenic surface. Our blood vessels therefore play a key role in homeostasis. In response to vascular injury however there

Efficacy of exercise intervention for weight loss in overweight and obese adolescents: Meta-analysis and implications

The global rise in obesity prevalence among children and adolescents has been linked to modifiable lifestyle factors, including lack of physical activity. However, no known meta-analysis has been conducted on the effects of exercise intervention on body

Active role of cell-derived microparticles in diabetes associated cardiovascular complications

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (or hyperglycaemia) resulting from defects in insulin secretion from the pancreatic beta cells, insulin action, or both. The chronic hyperglycaemia produces disturbances of carbohydrate, fat and

A better, safer clot buster for heart attacks, strokes and other cardiovascular diseases

A clot that obstructs blood flow triggers the onset of most heart attacks and 85% of strokes, the leading causes of death and disability worldwide.  Reestablishing blood flow rapidly limits damage to the heart or brain, saves

Collateral damages and self-inflicted scars by inflammation in cardiovascular diseases

Inflammation is a double-edged sword used by the body to initiate the healing process. However, persistence of immune responses can cause progressive destruction of tissues culminating in self-destructive autoimmune reactions which is a hallmark of many diseases. 

Good morning… let the stress begin. What is stress and how do we study it?

The American Psychological Association estimates that more than 70% of Americans regularly experience the physiological or psychological symptoms associated with chronic stress, with a third of the population thought to be living with extreme levels of stress.

Secret of cardiovascular diseases (CVDs) hidden in small molecules

Diagnosis and treatment of cardiovascular diseases (CVDs) are a great challenge for today’s medicine. It also results from not fully explained pathomechanisms underlying their development and progression. The group of CVDs is a very complex mixture of

G protein signaling: a major culprit of essential hypertension

Blood pressure (BP) is the driving force that distributes the blood to the organs of the body according to their instantanous needs. It may be increased by pressor agents acting on the heart, vessels, and blood volume,

High prevalence of undertreated cardiovascular disease in patients diagnosed with cancer

Heart disease and cancer are the most common causes of death in the United States. They often have the same risk factors (for example, smoking, advancing age, obesity). Heart disease can worsen outcomes after cancer therapy and

Road traffic noise linked to deaths and increased risk of stroke

Traffic noise is a known environmental risk factor for health. Health effects of noise exposure are hypothesised to occur via several pathways. Exposure to noise may affect the autonomic nervous system increasing heart rate, blood pressure and

Treating primary cardiac angiosarcoma

Radiotherapy and chemotherapy are usually reserved for inoperable patients or given adjuvantly for those with residual tumor and/or metastatic disease. Elsayad and coworkers describe a novel treatment modality with adaptive radiotherapy using tumor-volume tracking in a 37-year-old

Childhood psychosocial adversity and adult neighborhood disadvantage as predictors of cardiovascular disease

Childhood adverse psychosocial factors, such as parental divorce and long – term financial difficulties, have been linked to increased risk of cardiovascular disease. This is also the case for neighborhood socioeconomic disadvantage in adulthood. However, the combined

Busy traffic – risk of having cardiac disease

Air pollution from vehicles has been related to cause respiratory and cardiovascular diseases. There are many pollutants; most harmful of them is considered to be particulate matter (PM). Small in size, they are composed of toxic heavy

In vitro test bench to reproducing pulsatile flow conditions

Cardiovascular diseases are among the top causes of mortality in the world. Huge efforts are made to fight against the cardiovascular diseases. However, the variability of the symptoms and risk factors makes this fight very challenging. While