Tag Archives: CDK4

The discovery of anticancer compounds as a highly potent and selective Cyclin-Dependent Kinases 4 and 6 inhibitors

2D model of Abemaciclib bound to the active site of CDK6

Cell cycle is a highly regulated process that leads to the transition from quiescence or cytokinesis to cell proliferation through its checkpoints ensures genome stability. More importantly, cyclins and cyclin-dependent kinases (Cdks) play an important role in

Potential biomarkers of CDK4/6 inhibitors in HR-positive advanced breast cancer

Thanks to the development of endocrine therapy, the mortality rate of estrogen receptor (ER)-positive breast cancer patients has been decreased drastically. In spite of the improvement, however, relapse and progression that are driven by different mechanisms are