Tag Archives: cell

The protein “CHIP” unfurls anti-aging activity

Researchers at the universities of Cologne and Bonn uncover the link between protein aggregation and aging. Not only does our way of life determine how long we live but so too does our genetic material. Of particular

Image Cytometer – NucleoCounter® NC-3000™

The NucleoCounter® NC-3000™ is an advanced image cytometer utilizing fluorescence imaging to characterize cell properties. The NC-3000™ can perform high speed cell count and viability determination and includes plug-and-play analytical assays of mammalian, yeast and insect cells.

NucleoCounter® NC-200™ – Automated Cell Counter

The NucleoCounter® NC-200™ is a high precision automated cell counter utilizing state-of-the-art image cytometry. With user adaptable protocols and specialized assays for counting a wide range of mammalian cells, including adipose-derived stem cells, T cells, aggregated cells

Active role of cell-derived microparticles in diabetes associated cardiovascular complications

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (or hyperglycaemia) resulting from defects in insulin secretion from the pancreatic beta cells, insulin action, or both. The chronic hyperglycaemia produces disturbances of carbohydrate, fat and

How to build a communication system for cells

Single cell organisms, such as amoebae, are able to live independently without the need for extracellular communication systems. However, multicellular organisms, such as insects, fish and mammals, require systems that permit individual cells to communicate to one

Do low frequency electromagnetic fields interfere with cellular physiology?

Electromagnetic radiation, fields, or waves have been around since the birth of the universe, with daylight as the most familiar one. We are continuously exposed to different EMFs, mostly without even noticing them. Depending on their frequency,

How does aspirin inhibit melanin synthesis?

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to act by directly suppressing the activity of cyclooxygenase, the key enzyme catalyzing the biosynthesis of prostaglandin, which induces inflammation. Therefore, NSAIDs are usually used for treating pain, inflammation, and fever.

How cells crawl… that’s right, crawl

Within our bodies, every cell must crawl – some only a few millionths of an inch, while others, like nerve fibers, must make their way from the spinal cord to the tips of our toes. The ability

A new target in the fight against breast cancer

Cancer cells differ from normal cells in many ways, including their abnormal growth and their ability to change shape and migrate to other tissues. These differences are partly caused by changes in the production of proteins and

Glycogen localisation of AMPK is a regulated process

AMP-activated protein kinase (AMPK) is a metabolic master kinase that plays a key role in maintaining energy homeostasis at cellular and whole body level. Recent evidence links AMPK activation to health benefits, such as increased longevity and

Bioengineered human pyloric sphincters with functional muscle and nerves

The gastrointestinal (GI) tract is a hollow tube that primarily functions to mediate the digestion of the food that we eat into forms of energy and nutrients that the cells and our body can use. The appropriate

Fast electric characterization of biological cells using an old idea of Maxwell

In his treatise, James Clerk Maxwell (1873) did not only derive his famous equations but he also provided the mathematical description of the direct current (DC) resistance for dilute suspensions of shelled spherical objects. At his time,

How to spot a sick cell?

Mass spectrometry (MS) is a technique used to measure the mass of molecules. Chemists extensively use this method to confirm that they have made the right molecule by comparing the mass of the actual product with the

How fat is a cell?

Cells have characteristic sizes in different tissues from big cells like muscle cells to small cells like platelets. How is the size of a cell programmed? The answer is we don’t know. But we do know something

Microfluidic live-cell microarrays

In recent years, the development of new drugs and therapies has decelerated despite the application of combinatorial biochemistry and new therapeutic strategies, such as nanoparticle-based drug delivery systems. Although the numbers of newly developed compounds have steadily

Metformin is a potential remedy for the treatment of Gaucher disease

Glycosphingolipids (GSLs) are amphipathic compounds consisting of oligosaccharides and hydrophobic chain of ceramide. They are ubiquitously distributed in the outer leaflet of the plasma membrane and believed to be involved in a large number of cellular processes,