Tag Archives: chagas disease

Proline analogues present anti-Trypanosoma cruzi activity through inhibition of proline transporter

Trypanosoma cruzi is the protozoan parasite that causes Chagas disease, an illness that affects approximately 7 million people in Latin America. Nowadays there are only two drugs approved for Chagas treatment, benznidazole and nifurtimox. Both drugs were

Chagas disease a neglected ills without treatment

Chagas disease (CD) is transmitted by the parasite Trypanosoma cruzi, and was discovered in 1909 by the Brazilian medical doctor named Carlos Chagas. Until today, CD remains a serious public health problem, with more than 7 million

Are we still on the right track for a new medicine for Chagas disease?

Across 21 countries from Latin America there is a parasite named Trypanosoma cruzi, which causes an illness that is a frightening burden to public healthcare: Chagas disease (CD). The parasite is found in the gut of kissing

Attenuated bacteria as a DNA-delivery system for Chagas disease vaccine

Chagas disease caused by the parasite Trypanosoma cruzi, is considered by the World Health Organization (WHO) one of the most neglected tropical diseases worldwide. Prevalent in developing countries, it has a major social and economic impact in

Polyamine transport increases drug resistance in the parasite Trypanosoma cruzi

The parasite Trypanosoma cruzi is the causative agent of Chagas disease, an illness affecting millions of people in America. The only drugs approved against Chagas disease are nifurtimox and benznidazole, which were discovered almost half a century

The search for new drug candidates to treat Chagas disease

Chagas disease (CD) is a parasite-born pathology caused by a unicellular microorganism called Trypanosoma cruzi. This illness causes a significant morbidity and mortality in the developing world, being endemic in 21 countries across Latin America, representing also

Resveratrol: A natural product that kills the parasite responsible for Chagas disease

Chagas disease is a neglected illness affecting approximately 10 million people in the Americas, caused by a parasitic microorganism called Trypanosoma cruzi. There are only two drugs used against Chagas disease, which are effective only in the

Waltheria indica constituents to tackle Chagas disease

American trypanosomiasis, also known as Chagas disease, is one of the most serious protozoan diseases which occurs throughout Latin America. Its etiological agent is Trypanosoma cruzi, a flagellate protozoa, which is transmitted to humans and other mammals