Tag Archives: chemotherapy

Mucinous appendiceal neoplasms – is right colon resection necessary?

Appendiceal neoplasms are rare and often show low-grade histologic features. Symptoms and signs related to peritoneal metastases most commonly results in a diagnosis. Historically, epithelial appendiceal neoplasms have routinely been treated by a right colectomy. However, three

Loss of Trpm2 does not potentiate standard acute myeloid leukemia chemotherapy

Leukemia is a cancer of the blood that affects thousands of people of all ages (including children and even babies). Treatment is very toxic, and often fails to cure patients. Leukemia is caused by mutations in specific

Proteome view on how leukemia cells communicate with their environment to escape chemotherapy

Relapse continues to pose a major challenge to successful chemotherapy of adult acute myeloid leukemia (AML). Even though 80% of AML patients achieve remission, in which the bone marrow is virtually clear of leukemic cells, still almost

Why women with early stage breast cancer don’t complete their chemotherapy treatment?

Breast cancer is a leading cause of cancer death among US women.  For women with early stage breast cancer (stages I and II), completing chemotherapy after surgery can increase survival.  Despite this proven benefit, some women do

MSX1 sensitises cells to ovarian cancer treatment

Ovarian cancer is an insidious disease which in the majority of cases is diagnosed only at a very late stage. The majority of ovarian tumours are of a particular aggressive type, called high grade serous ovarian cancer.

The youth hormone DHEA in the treatment of liver cancer: die another way

Hepatocellular carcinoma (HCC) is a common form of malignant liver tumor and one of the leading causes of death all over the world. As for other types of cancer, many drugs have been developed and tested with

UNC Medical Center reduces time patients wait for their chemotherapy

Lean and Six Sigma principles are used in manufacturing and more recently, healthcare, to eliminate waste, defects, and variability in processes. These philosophies are used to develop solutions to workflow challenges in an effort to improve process

A replacement for chemotherapy?

Metastasis is a process where cancer cells of primary tumors gain properties enabling them to escape from the primary tumor and move to a secondary location in the body where they develop additional tumors. This event in

An important new tool to assess chemotherapy response in cancer patients

Although chemotherapy agents are widely used in the treatment of cancer, it is not widely known that for many patients with solid tumours, only a fraction receive a survival benefit from chemotherapy.  This is particularly the case

VIRTUOSO: Virtual clinical trials concept to help identify resistant tumors

The use of anti-cancer drugs (chemotherapy) is one of the standard-of-care therapeutic treatments routinely applied in clinics. However, a significant portion of patients who show a good initial response to the chemotherapeutic treatment become unresponsive to the

Dogs with lymphoma have better therapeutic responses and longer lifespans if they revealed lower white blood cell count after chemotherapy

Chemotherapy is effective against rapidly growing neoplasm. Chemotherapeutic drugs also damage other rapidly dividing cells, such as bone marrow stem cells. Because white blood cells have the shortest life spans in the hemocyte, bone marrow suppression commonly

How cancer cells resist the action of microtubule-targeting chemotherapeutic drugs? A study of β-tubulin mutations

Microtubules (MTs) are essential structural components of cells. They are made up of polymers of protein subunits of α,β-tubulin and are highly dynamic, undergoing rapid phases of assembly and disassembly. The dynamic behavior of MTs is essential

Summary of: Screening for viral hepatitis prior to rituximab chemotherapy

There are an estimated 800,000-1.4 million people with Hepatitis B Virus (HBV) in the US. Patients with a low immune systems, such as cancer patients, are at an increased risk of reactivation of HBV if they have