Tag Archives: chronic

Serotonin and noradrenaline reuptake inhibitor (SNRI) for chronic musculoskeletal pain may be a red herring?

Dysfunction in the central serotonin and noradrenaline systems cause not only depression but also increased pain sensitivity. Many animal studies indicated that lumbar-intrathecal administration of serotonin and noradrenaline reuptake inhibitor (SNRI) could ameliorate the pain sensitivity which

Octreotide – a promising fight against chronic intestinal pseudo-obstruction

Chronic intestinal pseudo-obstruction (CIPO) is a rare disorder that affects the intestinal tract of children and adults. It is a chronic and devastating disease that has significant morbidity and mortality. CIPO is characterized by severe and disabling

Kinase inhibitors and new treatments for asthma and COPD

Kinases are enzymes that phosphorylate proteins, leading to their activation within cells. Over 500 kinases have now been identified in human cells and they activate many processes in the cells, including the production of inflammatory mediators. Kinases

Effects of natural remedies on wound healing

Chronic wounds are a frequent finding in clinical practice and one of the problems with high impact on social health, affecting mainly the elderly people with chronic diseases (diabetes, nutritional abnormalities, cardiovascular diseases, chronic motor deficit and

STAT3: The double edged molecular sword in Chronic Lymphocytic Leukemia cells

The common denominator of different types of cancers is an ever expanding clone that originates from a single cell. In acute leukemia the clonal expansion may be very rapid and the clone double its size sometimes within

Building capacity where it is needed

Once thought to be affecting only affluent countries, cardiovascular diseases, diabetes, obesity and other life-style related diseases (collectively referred to as non-communicable diseases or NCD) are now the leading cause of death and disability also in developing