Tag Archives: CRISPR/Cas9

Emerging diversity of the CRISPR-Cas system in cholera phages

Interactions of bacteria and their phages, which are viruses hostile to bacterial survival lead to the evolution of numerous phage resistance mechanisms.  CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated proteins) is such a defense system of bacteria. The

Angiotensin II actions on distal regulatory elements promote vascular dysfunction and hypertension

Cardiovascular diseases such as hypertension (high blood pressure) and atherosclerosis (blocked blood vessels) lead to heart attacks and strokes, and are highly prevalent worldwide. Furthermore, these complications are significantly accelerated in patients with diabetes. Angiotensin II (AngII)

A new drug combination rescues a rare Cystic Fibrosis mutation in patient tissue

University of Toronto researchers in the laboratory of Dr. Christine Bear, together with collaborators at SickKids Hospital (Toronto, Canada) and Proteostasis Therapeutics (Cambridge, Massachusetts), used computer simulations, cell-based systems and patient tissue to interrogate the consequences of

Cyagen Biosciences – Helping you choose the right animal model for your research

While many animal models are available “ off the shelf ” through various repositories and collaborations, generation of novel animal models has allowed for more effective studies, not limited by previously derived lines/ strains. Historically, researchers have