Tag Archives: cytokines

An introduction to modelling lymphocyte migration in vitro

Lymphocyte recruitment to inflamed endothelial cells (EC) is fundamental to immune homeostasis – providing both cell-mediated defence against disease, while also contributing to the resolution of inflammation. However, the dynamic relationship between lymphocytes and EC can become

Go with the flow: Studying the movement of T-cells to sites of inflammation

Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining

Conditioning the brain immune system through physical activity

Staying physically active is one of the most beneficial things that a person can do for maintaining whole-body health. It is well understood that physical activity is important for building muscle, improving cardiovascular health, and boosting metabolism.

The oncolytic virus ∆PK has multi-modal anti-tumor activity

Oncolytic viruses (OVs) are an emerging cancer therapeutic based on tumor cell lysis by replicating virus and the resulting release of cellular proteins [viz. tumor-associated antigens (TAAs)], which modulate tumor immunogenic cell death (ICD). OVs have a

Inflammation alters brain function and pain processing centrally

In the last couple of years, some fascinating abilities of the immune system have emerged: The immune system is tightly interconnected with the nervous system, and can directly affect how the brain functions, and how a person

Immunological disturbances observed in chronic alcoholism

Alcoholism is a complex behavioral disorder characterized by the loss of control over alcohol consumption often involving other drug abuse with a relapsing and remitting course leading to significant impairment. Chronic alcohol use and alcoholism damages many

Topical application of hyaluronidase accelerates cutaneous wound healing

Chronic wound care poses a significant biomedical burden. The management and treatment of chronic wounds affect millions of people annually; these numbers are rapidly growing worldwide owing to the increase in the aging population and a sharp

Electric fields drive macrophage healing functions

When the skin is cut, or otherwise injured, a spontaneous electrical current is created immediately at the wound and this promotes healing. Several studies have demonstrated how naturally generated electrical fields cause movement of skin epithelial cells,

Multiple injuries (polytrauma) result in skeletal muscle wasting and insulin resistance

Polytrauma is a combination of injuries that occur over a short period of time (simultaneously or within minutes of each other). These injuries can include burn, fracture, hemorrhage, trauma to the extremities, or penetrating trauma to the

Polyfunctional T cells induced potent anti-tumor efficacy

Adoptive T cell therapy is a form of cancer immunotherapy using T cells to target cancer cells.  In adoptive T cell therapy, white blood cells are collected from cancer patients, T cells (CD4+ and CD8+ cells) within

Exorcising autoimmunity

Moderately intense physical exercise, performed at regular intervals, is now firmly recognized as a safe and effective intervention by which to enhance quality of life. Despite this awareness, for many of us, as our age increases, so

Endocrine regulation of Alzheimer’s disease. The Achilles heel of dementia and other neurological conditions

Alzheimer’s disease (AD) is the most common disorder of the central nervous system and the most frequent cause of devastating dementia in the elderly. Typified by loss of memory and by cognitive decline, AD lowers the quality

The cellular advantage of using a macrolide for community-acquired pneumonia

Community-acquired pneumonia has been one of the top ten causes of death in the US over the last 60 years despite the widespread use of antimicrobials.  National guidelines (at idsociety.org) recommend two primary antibiotic regimens – one

The unappreciated role of the median eminence in energy balance regulation

Obesity results from a sustained imbalance between calorie intake and energy expenditure. It is associated with an increased risk of developing a variety of medical conditions that are widespread in Western countries, such as type 2 diabetes

The prognostic value of tumor markers and cytokines in patients with squamous cell cervical cancer

Optimal management of cervical cancer consists of appropriate treatment methods after the precise staging, following detection as early as possible, and the best salvage therapy. Early detection of recurrence, especially at the early stages in cervical cancer

Regulation of mediator’s expression and chemotaxis in mast cells

The increasing prevalence of inflammatory diseases worldwide underlines the importance to study the molecular mechanisms leading to these disorders. Recent genome-wide association studies based on large group of patients and healthy controls revealed candidate genes, which are