Tag Archives: diabetes

Active role of cell-derived microparticles in diabetes associated cardiovascular complications

Diabetes mellitus is a metabolic disorder characterized by high blood glucose (or hyperglycaemia) resulting from defects in insulin secretion from the pancreatic beta cells, insulin action, or both. The chronic hyperglycaemia produces disturbances of carbohydrate, fat and

Insulin analogue with reduced weight gain effect in diabetic patients: detemir

Diabetes mellitus is a progressive condition in which the glycated hemoglobin level (i.e. marker of average blood glucose levels) rises inexorably over time. Strict glucose control in patients with type 1 or type 2 diabetes mellitus reduces

Statins and diabetes: do the benefits outweigh the risks?

Cardiovascular disease (heart attack and stroke) is the leading cause of death in the United States. Prescription cholesterol-lowering medications have been shown to lower the risks for heart attacks and stroke. In fact, roughly 28% of Americans

Can antioxidants benefit the diabetic kidney?

People who have diabetes are at high risk of developing kidney disease that may require dialysis or transplantation. This has been known for a long time but there is still a need for new ways to prevent

New advances in the classification of diabetes beyond type 1 and 2: monogenic diabetes

The classification of diabetes has become increasingly complex in recent years, particularly in young patients, and now goes beyond the traditional forms of type 1 and type 2 diabetes. Type 1 diabetes, which is linked to the

A better way to measure heart disease risk for an overweight society

Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup

The earlier, the better and the controlled. Glucose level sensing in diabetic patients through nano biosensors

Gone are the days when there was a big pain for patients suffering from high blood glucose (blood sugar) level that early and rapid detection was a long wait & rather unpleasant. Now recently developed approaches using

A new drug target for healthful aging

With the aging population of the United States increasing every year, there is an increasing need to develop new therapeutic modalities to provide for healthful aging. Although longevity is generally considered positively in most families, and of

Poor blood sugar control in elderly people with diabetes is associated with increased infection risk

Diabetes guidelines for doctors (such as those by NICE) suggest that they consider relaxing the blood sugar control targets for older people. This is because older people are less likely to get the long-term benefits of improved

Prox-1 and adipogenesis

Adipogenesis is the biological process that controls adipocytes differentiation and is one of the most well studied models of cellular differentiation. Adipose tissue is involved in the control of energy balance and especially in the study of

Silencing a microRNA may keep the doctor away for diabetic wounds

Patients with diabetes are frequently afflicted with impaired wound healing that may progress into chronic, diabetic ulcers, often leading to complications including limb amputation with increased risk of morbidity and mortality. These ulcers occur not only in

Alternative splicing: the new frontier in diabetes research

The human genome is predicted to contain 22.000 coding genes, but more than 200.000 proteins are expressed in human cells. This discrepancy is explained at least in part by the presence of alternative splicing (AS), a key

Food and Nutrition cause liver and brain diseases with diabetes in the developing and developed world

In the world the consumption of a healthy diet is essential to prevent diseases such as obesity, diabetes and brain diseases. New discoveries in medicine indicate that a diet that is low in fat and carbohydrate lower

Disguising insulin as an antibody: a Trojan horse for type 1 diabetes prevention

Type 1 Diabetes (T1D) is an auto-immune disease. These diseases appear when our own immune system, which normally protects us from foreign pathogens (viruses, bacteria,…), attacks our own cells. In the case of T1D, T lymphocytes, which

Alzheimer’s disease or type 2 diabetes?

Alzheimer’s disease (AD) is one of the most common causes of senile dementia and it is estimated that by 2050, the number of cases will rise to 110 million. The vast majority of patients suffer from the

Exorcising autoimmunity

Moderately intense physical exercise, performed at regular intervals, is now firmly recognized as a safe and effective intervention by which to enhance quality of life. Despite this awareness, for many of us, as our age increases, so