Tag Archives: disease

Chronic pancreatitis: an inflammatory disease of pancreas

Chronic Pancreatitis: An Inflammatory Disease of Pancreas

Pancreas is very important organ in our body and it is located in the abdomen behind the stomach. Pancreas is a gland and secrets some chemicals called enzymes. It is a leaf like structure and divided in

TussisWatch: a smartphone system to identify cough episodes as early symptoms of chronic diseases

Variance Trends for Different Subsets and Two Levels of Validation

Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive diseases and often the terminal stage of heart and lung disease, leading to death and disability. Both of these diseases may manifest with similar conflicting

GSK-3 beta: a therapeutic target for Parkinson’s disease

Parkinson’s disease

Neurogenesis is a process of birth of newborn neurons from neural stem cells (NSCs). It is a complex, multistep process which involves NSC proliferation, differentiation, migration, maturation and integration of newborn neurons into existing neuronal circuitry. Continuous

Can EBI2 receptor protect brain cells (oligodendrocytes) from dying during disease?

EBI2 receptor in different brain cells and its role in brain disease

The four major brain-specific cell types in the brain are: (i) neurons, which transmit and process information via electrical signals, (ii) oligodendrocytes, which insulate neuronal axons with fatty sheets called myelin to ensure fast and complete electrical

Kidney function decline in polycystic kidney disease – it’s not always off the cliff

Examples of kidney function

Autosomal dominant polycystic kidney disease (ADPKD) is a relatively common (estimated to affect 1 in 1000 to 1 in 4000 persons all over the world) inherited disorder that leads to kidney failure in the majority of patients

Prognostic factors for PM/DM-ILD. A dilemma of treatment intensity?

Schematic representation of the predictive prognostic factors for PM/DM-ILD.

Polymyositis (PM) and dermatomyositis (DM) are idiopathic inflammatory myopathies of unknown causes. In PM/DM, interstitial lung disease (ILD) is one of the extramuscular manifestations and the principal cause of death. To improve the prognosis of PM/DM-ILD, it

Statins: Good for the heart, but do they impact the brain?

High cholesterol, termed hyperlipidemia, is a risk factor for cardiovascular disease. Therefore, keeping cholesterol levels low through diet and exercise has proven benefits for reducing heart disease risk. For adults who cannot meet their cholesterol targets through

Compounded medication for patients with rare diseases

Pharmaceutical compounding is the preparation of unlicensed medicines in order to meet specific patient needs that do not have a licensed (commercial) medicine available on the market. Especially for patients with rare diseases it is complementary when

Training the immune system to treat Niemann-Pick type C1 disease

Every year, at least 1 in 100,000 people worldwide is born with Niemann-Pick type C1 (NPC1) disease, a lysosomal storage disease. Lysosomes are cellular compartments which process an array of substrates – from DNA to nutrients –

Midkine controls natural bypass growth by regulating the bioavailability of VEGF

Cardiovascular occlusive diseases such as stroke, myocardial infarction or perivascular artery diseases (PAD) are a major personal and social burden. According to the World Health Organization, vascular occlusive diseases are the leading cause of death worldwide.  Current

A novel quantitative iron imaging strategy in hereditary hemochromatosis based on LA-ICP-MS

Hereditary hemochromatosis (HH) is the most frequent genetic disorder in Caucasians, which affects about 1 in 1000 people in the Northern European ancestry. It is an iron overload disease with typical clinical symptoms resulting from excess body

Can we treat cancer by targeting Treg subset without causing autoimmune disease?

The regulatory T cells (Tregs), are a type of CD4+ T cells that suppress the potentially adverse effect of the immune system and prevent autoimmune disease. Although they play a central role in maintaining self-tolerance, Tregs also

Angiotensin II actions on distal regulatory elements promote vascular dysfunction and hypertension

Cardiovascular diseases such as hypertension (high blood pressure) and atherosclerosis (blocked blood vessels) lead to heart attacks and strokes, and are highly prevalent worldwide. Furthermore, these complications are significantly accelerated in patients with diabetes. Angiotensin II (AngII)

A new drug to improve drug-eluting stents in coronary artery disease

Patients with symptomatic coronary artery disease often receive stent treatment in obstructed coronary arteries of the heart. Even though current generation drug-eluting stents perform very well in the short-term, concerns still exist about their long-term efficacy due

Prevalence of anti-DFS70 antibodies in patients with and without systemic autoimmune rheumatic diseases

The main role of the immune system is to protect the body from a wide range of foreign invaders. In some cases, the immune system recognizes a part of the body as “foreign” and starts to attack

Keyhole heart valve surgery after previous heart transplantation

Advances in heart transplant techniques and medication that control rejection and infections resulted in improved survival and quality of life. These improved long term outcomes are unfortunately paralleled by a variety of associated coronary-, mitral- and tricuspid

Could the humble banana help mitigate diseases?

Musa acuminata, is the scientific name of the wild species of banana that has reinvigorated interest in finding cures for diseases such as cancer, HIV and many more. The wild banana habituates the tropical and subtropical regions

Breathing problems in Parkinson’s disease: a common problem, rarely diagnosed

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. It is characterized by bradykinesia (slowness in movement) tremor, rigidity, and postural instability. Potential non-motor manifestations of PD include depression, anxiety, constipation, overactive bladder

TAFRO-syndrome and idiopathic multicentric Castleman disease: An analysis of a new subtype of the rare disease

Castleman disease (CD) is a group of three rare, poorly understood diseases that all involve excessive lymphocyte quantities. All three groups, therefore, are categorized as lymphoproliferative disease. The three groups of Castleman disease share similar lymph node

Overcome obstacles in the treatment of scarred kidneys

More than 10% of the world’s population suffer from chronic kidney disease (CKD), a serious disorder that leads to a prominent reduction in quality of life and might end fatally. Independent of its initial cause, virtually all