Tag Archives: drug delivery

Diving into the mucus – PEG micelles for oral delivery

Swallowing a pill of paracetamol for headache is fast and easy. The drug can be administrated at a desired time and location without any pain or assistance. Such is not the case for biological drugs like insulin,

Electrifying drug delivery

Most patients with chronic illnesses are treated with oral drugs and injections. These delivery methods are plagued by low drug efficacy and nonspecific side effects. In addition, studies estimate that as high as 60% of the patients

Unmet clinical needs in the treatment of systemic fungal infections. Reformulating repurposed drugs such as amphotericin B

A recent increase in the frequency of fungal infections has led to a higher number of fungal species that can cause these pathologies, as well as a decrease in the number of effective treatments against them due

The road to new aortic valve disease treatment: Innovations in 3D models and drug delivery

Calcific Aortic Valve Disease (CAVD) resulting in aortic stenosis is a common heart disease that affects 25% of people over 65 years old, causing 17,000 deaths per year in the USA. The aortic valve regulates blood flow

Manipulating a single microtubule by light

A cell is basically a miniature factory, which contains a large number of dedicated protein machines to perform various mechanical functions. For example kinesin is a linear motor protein which transport cargos such as organelles, chromosomes and

Enzymes digestible nanoparticles: a new generation of biodegradable drug delivery nanosystem

Pathologies with high death rates such as cancers may well have found their solutions with the rise of nanotechnology. Nanotechnology is a newly coined word encompassing the application of nanoparticles for all kinds of technological challenges. A

Theoretical design of drug carrying block copolymer micelles

One of the challenges of next generation drugs is the design of target-specific delivery of pharmaceutical agents to the cancerous tumors or diseased cells. Polymer micelles and hydrogels have been traditional candidates for drug-delivery purposes. Poorly soluble

Can a doughnut-shaped molecule help design new drugs?

Some of the most advanced and modern medicines, such as those used in the treatment of cancer rely heavily on their selective, high affinity targeting of cancerous cells in order to be effective medicine. However, some drugs

Diamonds – The doctors’s best friend?!

Most people know about diamonds as jewelry and as the hardest material that can cut nearly everything. It is also known that what makes diamonds unique is the crystalline structure, which is brought about primarily with high

Improving nature’s own communication system to fight cancer

Our bodies are composed of trillions of different cells, which communicate with each other in order to keep us healthy. There are several ways in which messages can be sent back and forth between cells. One of

New systems capable of stimuli-controlled release of drugs

The search for new medical strategies with high therapeutic efficiencies and reduced adverse side-effects remains a challenge for the scientific community. The development of new drug delivery systems (DDS) to generate new solid forms of active pharmaceutical

The right tool for the right job – it is brain surgery after all!

Getting drugs into the brain to help treat cancer or neurological diseases like Parkinson’s or Alzheimer’s is pretty difficult. Generally speaking you can’t just take a pill or get an injection as the brain is protected by

Milk exosomes for drug delivery

The need to effectively deliver drugs to target site has employed a multitude of substances varying from biological to a chemical nature and solid metals for the preparation of tiny drug delivery vesicles called nanoparticles. However, factors

Using Anthrax toxin (Atx) for drug delivery

When people think of toxins in relation to medicine, they usually think of the use of the toxins’ warhead. This warhead has been used to kill things like cancer cells when directed by a cell-targeting antibody. However,

Nucleus-targeted anticancer drug delivery

Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. However, efficient nuclear drug delivery upon systemic administration remains a

Evaluation of colon specific tablets using experimental induced colitis rat animal model

Colon forms the important part of large intestine located after caecum. Compared to other regions of gastrointestinal tract (GIT), movement of material through colon is slow. Therefore a dosage form taken orally could take from as less