Tag Archives: drug resistance

Cost-effectiveness of rapid diagnosis of drug-resistant tuberculosis

Globally, tuberculosis (TB) is a leading cause of premature death. There are treatments for tuberculosis, but drug-resistant strains of tuberculosis have emerged, mostly due to improper or incomplete treatment.  If diagnosed properly in a timely manner, extremely

Lernaean hydra puzzle in compensatory angiogenesis and tumor drug resistance

Diagrammatic representation of how compensatory angiogenic mechanisms are driven by redendent proangiogenic signalling

Before we proceed to apply the analogy of Lernaean hydra to compensatory angiogenesis and tumor drug resistance against anti-angiogenic drugs (AADs), let us have a cursory look at the interesting mythology of this hydra. According to Greek

A drug resistance gene mediates stringent response in bacteria

Model for physiological roles of M. smegmatis Arr

Mycobacteria represent an important group of bacteria. Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects about a third of the world population, of which 5% to 15% develop active disease. Furthermore, a rapid emergence of multidrug

Negative regulators of cell death signalling pathways in cancer

Cancer is a primary cause of human death with a global economic toll of around US$1.4 trillion each year. It is estimated that about 12 million people will yearly die of cancer by 2030. Conventional cancer therapies such

How does phenobarbital, a therapeutic sedative, activate a nuclear receptor through phosphorylation?

Steroid hormones activate a family of nuclear proteins called nuclear receptors to regulate every aspect of human physiology, reproduction, development, differentiation, metabolism and immunity. A nuclear receptor molecule is comprised of two major structural domains; DNA-binding (DBD)

A novel and quick method to study the drug resistance in reverse transcriptase (RT) of HIV

Human immunodeficiency virus (HIV), a retrovirus, was discovered independently by Luc Montagnier and Robert Gallo in 1983. As per the WHO report of 2015, globally, around 40 million people are infected with this virus. HIV is an

Holding the last line of defence against malaria

Malaria contributed to the deaths of almost half a million people worldwide in 2015. This disease mainly affects people in the developing countries and imposes a serious health and financial burden. Artemisinin (ART)-based combination therapy is the

Metabolic reprogramming: from estrogen dependence to self-sufficiency

Breast cancer is the most common cancer in women and, despite significant progress in diagnosis and treatments, incidence has been steadily increasing in the last 40 years. Approximately 70% of breast cancers are characterised by the expression

Is isoniazid so safe to use in tuberculosis preventive therapy?

Tuberculosis (TB) has emerged as a major warning to global public health as thirty three percent of the world population is considered to be infected with Mycobacterium tuberculosis (MTB)  infection.  Further, multi-drug-resistant strains of MTB in association

Truncated INH-NAD adduct, an active intermediate in the action of Isoniazid (INH) against InhA enzyme in tuberculosis

Tuberculosis (TB) remains as an important infectious disease, caused by Mycobacterium tuberculosis (MTB) which is responsible for around 1.5 million deaths and 9.6 million new cases annually. Isoniazid (INH), a bactericidal compound used as a first-line drug

Polyamine transport increases drug resistance in the parasite Trypanosoma cruzi

The parasite Trypanosoma cruzi is the causative agent of Chagas disease, an illness affecting millions of people in America. The only drugs approved against Chagas disease are nifurtimox and benznidazole, which were discovered almost half a century

Mitochondrial ROS and cancer drug resistance

The repetitive and continuous circle of resistance to anti-cancer agents was a primary focus of the above-titled articles recently published in Pharmacological Research. Gaining a basic understanding of why so many (possibly all) drugs currently available against