Tag Archives: drug target

SLiMming the fuzz in gene-regulating interactomes

Organisms depend on strict regulation of their genes for proper cellular function. This regulation is mediated by large protein interaction networks – the so-called interactomes. By analogy to the World Wide Web, interactomes display a scale-free architecture

Clues for innovative therapies targeting the c-ring of the F1FO-ATP synthase

Increasing evidence points out that the ATP synthase/hydrolase, also known as F1FO-complex, can be the key enzymatic switch between cell life and death. So, the enzyme complex, which bears the task of building most cellular ATP, the

Heat shock protein as a novel druggable target in angiogenesis?

Angiogenesis is a physiological process that involves formation of new blood vessels from pre-existing vessels for efficiently providing oxygen and nutrients during growth and development, as well as during wound healing. Under pathological conditions, angiogenesis is regulated

Multiple tasks for the c-ring of the F1FO-ATP synthase

The F1FO-ATP synthase is the only enzyme in nature endowed with bi-functional catalytic mechanism of synthesis and hydrolysis of ATP. The enzyme complex is hosted in the inner mitochondrial membrane in eukaryotes and in the plasma-membrane in