Tag Archives: drug target
Advances in drug discovery and development in geriatric psychiatry
Drug discovery for disorders of the central nervous system is a long and challenging process, with a high attrition rate from the preclinical stages through to marketing a compound. In geriatric psychiatry, the heterogeneous nature of these
How the mitochondrial F1FO-ATPase can be chemically switched on/off and serve as drug target
The mitochondrial F1FO-ATPase is well known to play the main role in synthesizing most of ATP, thus providing energy to living cells under aerobic conditions. However the enzyme complex can also work in reverse and split ATP
SLiMming the fuzz in gene-regulating interactomes
Organisms depend on strict regulation of their genes for proper cellular function. This regulation is mediated by large protein interaction networks – the so-called interactomes. By analogy to the World Wide Web, interactomes display a scale-free architecture
Clues for innovative therapies targeting the c-ring of the F1FO-ATP synthase
Increasing evidence points out that the ATP synthase/hydrolase, also known as F1FO-complex, can be the key enzymatic switch between cell life and death. So, the enzyme complex, which bears the task of building most cellular ATP, the
Heat shock protein as a novel druggable target in angiogenesis?
Angiogenesis is a physiological process that involves formation of new blood vessels from pre-existing vessels for efficiently providing oxygen and nutrients during growth and development, as well as during wound healing. Under pathological conditions, angiogenesis is regulated
Multiple tasks for the c-ring of the F1FO-ATP synthase
The F1FO-ATP synthase is the only enzyme in nature endowed with bi-functional catalytic mechanism of synthesis and hydrolysis of ATP. The enzyme complex is hosted in the inner mitochondrial membrane in eukaryotes and in the plasma-membrane in
