Tag Archives: drugs

3D environment enhance cellular capacities

Although we live under the 3D (three-dimensional) environment, drug testing is carried out usually by using isolated cells cultured under the 2D (two-dimensional) environment. Liver is a very important organ which metabolizes glucose, alcohol, lipids (e.g. cholesterol)

Receptors as drug targets

According to the latest count, human body has 37.2 trillion cells. They all have the same genetic material, half deriving from a sperm cell, the other half from an egg cell. Consequently, all the cells are in

The binding of mGluR4 targeting drugs could help the finding novel treatments for PD

One of the key features of drugs is an ability to find the corresponding target molecule (eg. protein) from the body. The target protein has unique structural sites that could be loaded with specific chemicals (drugs). The

Renal risk associated with sodium phosphate medication

Sodium phosphate drugs (solutions, tablets or enemas) are used since 1990s as laxatives for bowel cleansing before endoscopy and radiology examination, or occasionally for treatment of severe constipation. Sodium phosphate drugs are low-volume osmotic purgatives, their administration

Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice

Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs

New effective treatments for Alzheimer and Parkinson’s disease

Alzheimer and Parkinson’s disease are the most common neurodegenerative disorders. As people are getting older than in previous generations, the number of people who are affected has increased. Unfortunately, there is no cure for these diseases. The

A genetic switch for your health

We all have heard that reducing your caloric intake improves your health and may even extend your life. A fascinating aspect of calorie restriction is that it has similar beneficial effects in virtually all animal species tested.

Using cheminformatics to aid in the discovery of new drugs

Finding new medicines is a difficult and expensive endeavor and grows more difficult and expensive with every passing year. Thus, new ways to streamline the process are desperately needed by the pharmaceutical industry. Once upon a time,

Antimicrobial resistance – what’s needed but how to get the resources to the innovators?

Antibiotic resistance is at a crisis point, nay a “tipping point”. There are several major programs which offer what sound like large sums of money to make new antibiotics, but to get these monies takes a lot

High blood pressure is controlled more effectively by two drugs in one pill

Hypertension, or high blood pressure (BP), is a major global public health problem, both because of how common it is and its correlation with cardiovascular disease. It has been identified as one of the major risk factors

A new understanding of the mechanism of action of insulin sensitizing drugs provides insight into treating metabolic disease

It has been known for some time that there is a connection between diabetes and other diseases that increase with age, including important neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Interestingly, all of these diseases are

Nanoformulations for cancer therapy

Cancer is a major disease responsible for death in human beings. A lot of research has been performed to develop improved diagnostic tools as well as drugs to treat cancer. Effectiveness of therapeutics in cancerous malignancy is

The quest for targeted therapy in fragile X syndrome

For many years we believed that most hereditary diseases were untreatable. However, hopes for a cure were raised following the discovery of genetic causes and better understanding of disease mechanisms. This elucidated new targets for therapy. The

Identifying doses in commercial liquid drugs sterilized by ionizing radiation

Drug sterilization with ionizing radiation, such as gamma-radiation using doses up to 25 kGy is a well-established technology, which can adequately eliminate bacteria by breaking down their DNA. This method is gaining ground due to its numerous

How cancer cells resist the action of microtubule-targeting chemotherapeutic drugs? A study of β-tubulin mutations

Microtubules (MTs) are essential structural components of cells. They are made up of polymers of protein subunits of α,β-tubulin and are highly dynamic, undergoing rapid phases of assembly and disassembly. The dynamic behavior of MTs is essential

Using Darwin to discover new advanced materials

The process of evolution, first described in detail by Charles Darwin, has resulted in the amazing diversity of plants and animals in our world, each subgroup shaped by the effects of the different environments in which they

Pharmacist’s role to help patients get the most out of their medications

Many patients do not adhere well to their prescribed medication regimens. Evidence shows that improving medication adherence leads to lower overall health care use and costs. As a result, healthcare stakeholders are increasingly interested in improving patient

New drugs for cancer treatment

Cancer is a major cause of death and more than 1 million people in the United States are diagnosed with cancer each year. Finding more effective methods to treat cancer remains a challenge, and researchers are working

Obesity causes lung dysfunction and breathing troubles by increased cysteinyl leukotrienes pathway

Increased body weight is a chronic health problem which has emanated from the globalized food market and dietary habit. This has led to the different types of ailments which occur in obese individual simultaneously and referred to

A potentially lethal condition that may occur in psychiatric patients

Antipsychotic drugs are commonly prescribed in patients with various psychiatric illnesses (e.g. psychosis, schizophrenia, aggressive behavior, etc.). A neurological emergency may arise characterized by muscle rigidity and damage, increased body temperature and cardio-respiratory system instability in patients