Tag Archives: F1FO-ATPase

Calcium ion by replacing magnesium ion unravels an unexpected role for the mitochondrial F1FO-ATPase

The F1FO-ATPase/synthase is universally known as a complex enzyme machinery which, embedded by the FO portion in the inner mitochondrial membrane and the catalytic F1 sector protruding in the matrix, matches the transmembrane proton flux which occurs

How the mitochondrial F1FO-ATPase can be chemically switched on/off and serve as drug target

The mitochondrial F1FO-ATPase is well known to play the main role in synthesizing most of ATP, thus providing energy to living cells under aerobic conditions. However the enzyme complex can also  work in reverse and split ATP

The dual role of mercury on mitochondrial complexes by sulfur bridges

All forms of mercury are long known to be highly toxic. In recent years, the metal occurrence in dental amalgams has raised worries for the harmful effects due to the slow mercury release in the human body.