Tag Archives: gene
A DNA repair gene, OGG1, polymorphism affects relapse risk of acute myeloid leukemia
Approximately 80% of acute myeloid leukemia (AML) patients can achieve complete remission, but around half of them relapse within five years. Defining the mechanism of relapse is essential to improve the prognosis of AML. Recently, a clonal
Repetitive DNA in the ABCA7 gene influences Alzheimer’s disease
Dementia, which is characterized by decline of memory or other cognitive traits to the extent that a person’s daily functioning is affected, is one of the most important global health challenges of our time. Approximately 50 million
New literacy challenge: genetic knowledge is poor even among well educated
The beginning of the 21st century marked the beginning of the genomic era and of a new literacy challenge – genetic literacy. From genes we can now extract information related to all aspects of peoples’ lives. This
Functional gene analysis to understand complex biological mechanisms in schizophrenia
Schizophrenia (SCZ) is a chronic debilitating psychiatric disorder affecting approximately 7 in 1000 people in their lifetime and ranked as one of the top 15 leading causes of disability worldwide. The symptoms of SCZ can be divided
Alzheimer’s risk gene weakens brain cell’s garbage disposal system
APOE ε4 is the most common genetic risk factor for development of Alzheimer’s disease. Having two copies of this gene (one from the mother and one from the father) increases a person’s relative risk to as much
Mitochondrial gene discontinuity that translates into fragmented functional proteins
The majority of protein-coding genes in nuclear genomes are interrupted by spliceosomal introns or, less often, by inteins. These intervening sequences are spliced at the RNA or protein level, respectively, so that intact proteins become reconstituted. In
Transcription modulation in Xanthomonas citri subsp. citri
Xanthomonas citri subsp. citri (X. citri) is a Gram-negative bacterium and the etiological agent of citrus canker, a severe disease that affects all the commercially important citrus varieties with worldwide distribution. The best method to control the
Too hard to defeat Devils
Hematopoietic cell transplantation (HCT) offers potentially curative therapy for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). However, relapse following HCT is considerable and becomes a major cause of failure in patients with MDS and AML.
New insights into the cause of Prader-Willi syndrome, a rare obesity-related genetic disorder
Prader-Willi syndrome (PWS) is a complex genomic imprinting disorder caused by the loss of paternally expressed genes in the 15q11-q13 region usually due to a chromosome 15q11-q13 deletion seen in about 70 percent of those affected with
Molecular mechanism of phenotypic plasticity
Darwinian evolution is considered to be the way that life adapts in every possible environment in Earth. The great evolutionary biologist of the past century Theodosius Dobzansky used to say: “Nothing in Biology Makes Sense Except in
A new technology for employing artificial trans-acting small interfering RNA
A central doctrine for a gene expression is typically from the DNA coding sequence to the RNA transcript and then to the protein. So, the normal function of a gene can be disrupted by suppression, or so-called
Patterns of mutation in cancer genes
In most cancers, the majority of the changes to the DNA (termed mutations), acquired during the disease process are inconsequential in terms of driving the cancer, however a few of the changes in a small set of
Cyagen Biosciences – Helping you choose the right animal model for your research
While many animal models are available “ off the shelf ” through various repositories and collaborations, generation of novel animal models has allowed for more effective studies, not limited by previously derived lines/ strains. Historically, researchers have
From parasitic microfungi towards the origins of Microsporidia
Microsporidia are unicellular eukaryotic parasites, infecting virtually all animals including humans. They are characterized by peculiar morphological and genetic features, which are the result of their extreme adaptation to the intracellular lifestyle. Interestingly, the infection apparatus in
G-quadruplexes: novel DNA structures controlling life from the beginning
The process by which a single cell, the zygote, becomes a fully formed organism has been a historic scientific enigma. Now we know that the information stored in the genes of the DNA is the responsible for
Unravel the key genes potentially related to high strength of cotton fiber by comparative phenotypic and genomic analyses
The demand of high strength of cotton fibers has been increased dramatically with the advent of modern high speed spinning technology for producing yarn. Cotton fiber is a gigantic single cell which consists of almost pure cellulose.
Protection from DNA-damage with the natural compound resveratrol
Resveratrol is currently known as a health-beneficial natural compound that is contained in grape skins, red wine, and other natural foods. Recent studies suggest that the compound could elongate the life spans of several organisms through a
Prox-1 and adipogenesis
Adipogenesis is the biological process that controls adipocytes differentiation and is one of the most well studied models of cellular differentiation. Adipose tissue is involved in the control of energy balance and especially in the study of
Allelic variations within genes coding for cytokines among Orang Asli in Peninsular Malaysia: New candidate genes for future disease studies
Cytokines are a set of low molecular weight proteins/glycoproteins secreted by almost all types of cells. They regulate cell growth, immune response and blood cell development in the bone marrow. Genetic variations in cytokine genes include single
