Tag Archives: gene

The exploration of gene expression in Atlantic bluefin tuna

Atlantic bluefin tuna (Thunus thynnus), the largest of the tuna species, is migratory top predator inhabiting the North Atlantic Ocean and the Mediterranean Sea. Extremely well adapted to life in open waters, they are able to traverse

PACAP expression induced in neuropathic pain is controlled by a splicing of REST/NRSF

Neuropathic pain (NP) is caused by the damage of the nervous system and one of the most common types of intractable pain. It is often severe, persistent, and refractory to available therapies. Although various analgesic has been

Understanding conifer responses to environmental changes

Conifers are a group of ancient plants that include tree species of great ecological and economical relevance. Inside this group, we can found trees such as pines, cedars, firs, spruces or cypresses. Coniferous forests dominate vast regions

Going my way? A tale of enzyme recruitment and activation

Protein synthesis is an energetically costly cellular process, in part due to the metabolic requirements of ribosome assembly and gene-specific messenger RNA (mRNA) production.  Consequently, biosynthetic flux through the protein translation pathway is tightly regulated while translational

G protein signaling: a major culprit of essential hypertension

Blood pressure (BP) is the driving force that distributes the blood to the organs of the body according to their instantanous needs. It may be increased by pressor agents acting on the heart, vessels, and blood volume,

Gene therapy: a promising candidate for cystic fibrosis treatment

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular

Genome sequence of the natural antagonist Pseudomonas fluorescens 2-79 against fungal plant diseases

In agriculture we have to deal with a huge variety of diseases caused by phytopathogenic bacteria, fungi or insects for instance. Many of these plant pathogens live in the soil and attack the respective cultivar at the

Why do people undergo genetic testing – for personal benefits, for family, or for science and society?

Genetic testing is an important tool to detect gene mutations (e.g., BRCA1/2) that increase the risk of cancer, especially among those who are known to have higher chances of carrying these mutations such as Ashkenazi Jewish individuals.

Prader-Willi syndrome: most common genetic cause of life-threatening obesity

Prader-Willi syndrome (PWS) is a rare complex multisystem genetic disorder. It is recognized as the most common known genetic cause of obesity in humans which can be life-threatening, if not controlled. PWS affects about 1 in 15,000

Association of polymorphism gene with clinical variability in cystic fibrosis patients

Cystic fibrosis (CF) is an inherited disease, caused by a dysfunction (mutation) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. This disease affects a numerous organs particularly the lungs and digestive system. CF is characterized by

Whole-cell computational models can predict how genes influence behavior

Since the early 1900’s, scientists have known that cells are composed of multiple components, including small molecules, DNA, RNA, and protein. Over the past fifty years, scientists have systematically measured these individual components and their interactions. Despite

Genes are read backwards to restructure our DNA

In English, we read in one direction – from left to right across the page. We need to read words in a certain order, so that the information makes sense to us. In the cells of our

How to know transcription factors by the company they keep

The ENCODE project is a massive data-collection effort set out to understand the function of the human genome. The collection comprises many types of genomic data, including the localization of transcription factors onto DNA. Transcription factors are

A resource for studying the role of RNA-binding proteins in human disease

Advances in science and technology have not only made accessing and analyzing the personal genomic information a reality but also rapid and cost effective. Every living organism is made of cells and every cell is made of

Escherichia coli K-12 as a model to understand gene regulation

Escherichia coli K-12, a bacterium of the normal flora of humans, represents one of the most important model organisms in biology. This microorganism has been completely sequenced at DNA level, and contains 4319 genes. An important element

Controlling gene expression in bacteria

Gene expression enables cells to implement the instructions encoded within the genes on their DNA. Being able to control gene expression is therefore key to this most fundamental biological process, so determining cell fate and behaviour. Cells