Tag Archives: genome

The journey of Campylobacter: a genomic analysis of a successful zoonotic pathogen

Campylobacter is the leading cause of human gastroenteritis worldwide. Domestic and wild birds are likely zoonotic vectors of Campylobacter. We demonstrated that American crows, abundant in urban, suburban, and agricultural settings, carry multiple Campylobacter genotypes that are

Genetic disorders in primary aldosteronism – familial and somatic: an explanatory attempt

Aldosterone is the steroid hormone secreted from the adrenal gland in response to sodium deficiency, blood volume loss or potassium loading. It acts on the kidney and the colon to retain sodium and excrete potassium, in a

Plants versus pathogens: detection and deception

Novel research has unveiled more about the deception tactics used by plants in their continuous battle against attacks from disease-causing pathogens. These findings could help in breeding better crops to reduce losses and produce more food. In

HOX genes: The Rosetta Stone of the human cells biology

The cell memory program is a biological process that oversees several aspects of the cell life: i) where the new generated cell will be located ii) the fate of a new cell and the cell phenotype; iii)

Life on sulfur. Why we need complete genomes

The ability of bacteria to grow on inorganic compounds like sulfur was discovered by Russian microbiologist Sergey Winogradskij in 1888. First, he studied a sulfur bacterium of the Beggiatoaceae family to demonstrate that it can produce energy

Sequence of the plant beneficial biocontrol agent Pseudomonas fluorescens DSM 8569

Pseudomonas represents an abundant bacterial group that can live in the soil. In this habitat many organisms like fungi, bacteria, plants or insects live together, often intensively interacting in close communities. The composition of these communities is

Endospore formation: a mechanism for microbial response to unfavorable environment

The strain included in the report is Bacillus sp. CHD6a, a member of the phylum Firmicutes isolated from the shallow-sea hydrothermal vent systems off northeast Taiwan’s coast. Bacillus is a genus of Gram-positive, rod-shaped and ubiquitous in

Genome sequence of the natural antagonist Pseudomonas fluorescens 2-79 against fungal plant diseases

In agriculture we have to deal with a huge variety of diseases caused by phytopathogenic bacteria, fungi or insects for instance. Many of these plant pathogens live in the soil and attack the respective cultivar at the

Can hypertension and related cardiovascular diseases be caused by Dark-Matter-like RNAs?

Hypertension is a common but one of the most important health problems, because it is a major risk factor for many cardiovascular diseases. Hypertension is a multi-factorial disease involving complex interplay of genetic and environmental factors. To treat

Active-state of AT1 receptor attenuates inverse agonism of ARBs through changes in specific ligand-receptor interactions

G protein – coupled receptors (GPCRs) constitute one of the largest gene superfamilies in the human genome. The angiotensin II ( Ang II ) type 1 receptor ( AT1R ) belongs to G – protein coupled receptor

How to know transcription factors by the company they keep

The ENCODE project is a massive data-collection effort set out to understand the function of the human genome. The collection comprises many types of genomic data, including the localization of transcription factors onto DNA. Transcription factors are

AMPK: Common mechanism of action linking HIV-1 latency and Hutchinson-Gilford progeria syndrome

Although any connection between HIV-1, the virus that causes AIDS, and Hutchinson-Gilford progeria syndrome, a rare genetic disorder that exhibits symptoms of accelerated aging in children, would appear unlikely, splicing of the latent ( i. e. dormant)

A hereditary mutation in Schwartz-Jampel syndrome

Schwartz-Jampel syndrome (SJS) type 1, also known as chondrodystrophic myotonia, is a rare autosomal recessive disorder characterized by short stature, neuromyotonia (sustained contraction of skeletal muscles), chondrodysplasia (abnormal development of the cartilage of long bones), joint contractures,

Using Darwin to discover new advanced materials

The process of evolution, first described in detail by Charles Darwin, has resulted in the amazing diversity of plants and animals in our world, each subgroup shaped by the effects of the different environments in which they

Using genome-scale models to predict biological capabilities

Rapid advances in DNA sequencing and synthesis technologies have revolutionized the study of life sciences. With these new technologies come new challenges. The massive amount of new data generated using these technologies must be curated, managed, and