Tag Archives: heart

Silk patches to repair hearts

The heart is a very sensitive organ. Once it’s “broken”, it doesn’t quite function the same way again. Biologically speaking, a common way of getting your heart broken is when you suffer a heart attack. When the

Depression severity is related to the development of heart disease in previously cardiac health subjects

Depression is a disabling, high-prevalence psychiatric condition. It is well established that depression is linked with physiological changes that can contribute to an unfavorable outcome in cardiac patients. As depressed patients exhibit impairments in the autonomic nervous

Nerves are required to repair the injured heart

Cardiovascular diseases (CVD), such as heart attack, are responsible for approximately 18 million deaths each year, which accounts for more than 30% of all deaths worldwide. CVD is the single greatest cause of death in humans killing

Evaluation of heart rate measurements in clinical studies – Which way to do it right?

100.000 times a day – this is the daily number of heart beats in human beings. This huge workload normally will pass by unobserved in a healthy being, but in a patient with heart disease any alteration

Lymphatic drainage of the heart

Someone once said that each man is his own island. I would make the analogy that our body is a country, where each organ is a city, each cell a building or factory in the city, and

Jurassic siphon

The sauropod dinosaurs were the tallest animals to ever stalk the earth. The fossilised remains of sauropods indicate that some had necks as long as 12 m.  Sauropods are often depicted with their heads held high –

Infections in right-sided heart valves often leave doctors with no right answer

A normal human heart has four chambers and four valves. When these valves are working well, they stop blood from flowing backwards and are essential to good heart function. Two valves are in the right side of

Coronary ostoplasty for congenital atresia of the left main coronary artery ostium in a teenage boy

Coronary artery abnormalities are reported as the third largest cause of sudden death in young athletes. Because patients usually do not have any apparent abnormality on medical examination, it is difficult to detect this before some events.

Heart defects before birth: Why are most cases still being missed (and what can we do about it)

Heart defects occur in roughly 1 in 100 live births—far more than any other kind of birth defect. Over the past decade, it has become increasingly clear that babies with major forms of heart disease have must

Obesity enhances the risk of arrhythmia

The heart consists of 4 chambers in mammals. The upper two chambers are atria, and the lower ones are ventricles. Ventricles work as pump to eject blood to whole body. Atria have 2 important roles: 1) to

A better way to measure heart disease risk for an overweight society

Low density lipoprotein (LDL) cholesterol or the “bad cholesterol” is an established measure of cardiovascular risk. LDL particles interact with the lining of the blood vessel and contribute to cholesterol loading in the arterial wall. Continued buildup

Fighting chronic rejection of transplanted organs

In many diseases the only available cure is organ transplantation. However, if the transplanted organ does not derive from an identical twin (which is genetically identical to the recipient) it becomes rejected by the immune system of

The heart’s own acetylcholine important in health and disease

Tissues and organs of our body are under the control of active chemical compounds. Hormons are released from  endocrine glands and reach the targets with blood.  Transmitters are released from the endings of nerve fibers. If the

Melatonin reduces blood pressure and tunes up disrupted circadian rhythms in the seniors

The older we get the more likely our circadian rhythms are disrupted. For example, blood pressure not only tends to increase but as well become more irregular. Luckily, as we show here, melatonin helps to ameliorate both

A transcriptomic approach for cardiac (heart) safety assessment

New drug discovery relies on several phases of safety assessment. One such prominent in vitro safety assessment assay is the “hERG potassium channel assay” for cardiac safety. If a compound blocks the hERG potassium channel in a

Heart and blood pressure adverse effects of phenytoin

Phenytoin is an effective antiepileptic drug which is used for many years in the treatment of epileptic seizures. Whereas its oral form is used for the long-term treatment of epilepsy, the intravenous form – the injection into