Tag Archives: inflammation

Role of the gut in systemic inflammation

The multi-layer wall of the intestine is unique and important due its barrier function for billions of potential deadly gut bacteria and the sterile tissues in the body. For this reason, the intestine is equipped with highly

P2X7 antagonism: a specific tool to decrease inflammatory status in human atherosclerotic vessels?

Atherosclerosis is a dynamic progressive disease of the large arteries characterized by the tendency to accumulate lipids, inflammatory cells, smooth muscle cells and extracellular matrix within the sub-endothelial space, and progressing in unpredictable way to different stage.

An introduction to modelling lymphocyte migration in vitro

Lymphocyte recruitment to inflamed endothelial cells (EC) is fundamental to immune homeostasis – providing both cell-mediated defence against disease, while also contributing to the resolution of inflammation. However, the dynamic relationship between lymphocytes and EC can become

Go with the flow: Studying the movement of T-cells to sites of inflammation

Inflammation is the protective response of the immune system that aids the removal of invading infectious agents and repair tissue injury. It involves the movement of white blood cells (leukocytes) from the bloodstream, through the cells lining

Biodegradable microparticles used to prolong drug release to inhibit inflammation in osteoarthritis

Articular cartilage is located on the surfaces of the bones in the synovial joint. It protects the underlying bones from damage and shock, but also functions as a lubricant for frictionless movements of the human body. Damage

Incretin hormones and brain microglia team up to regulate brain homeostasis

The entire human body is made up of many complicated cells, processes, and interactions. As scientific discoveries are made, it becomes increasingly more evident how multidimensional and interconnected all of the biological systems and pathways of the

The mechanisms of MCP-1 production in tumor microenvironments: Tumor cells are not home alone

When you look at tumors, you may think they are composed of 100% tumor cells. The fact is that tumor tissues contain not only tumor cells but also a variety of non-tumor stromal cells, including fibroblasts, endothelial

Immune damage of Apical Epidermal Cap impedes limb regeneration in frog

The evolution of the immune system in terrestrial vertebrates has allowed a high efficiency in the protection against mutated and cancer cells, foreign substances and microbes. Immune cells however become fully immunocompetent only late during development or

Chemokines, an answer to the gut inflammation?

Our gut is a complex organ which not only digests the food but also acts as an immune organ. The gut is lined by a single layer of specialized cells called as intestinal epithelial cells (IECs) which

Short technical steps to success in inflammation research

Taking a chemical compound from early discovery to clinical trials is a process that is fraught with risks. It is therefore, important to optimize preclinical test systems to improve the chances of developing a compound likely to

Disturbed sleep matters to patients with ankylosing spondylitis

Disturbed sleep is a significant problem for patients suffering with long-term, inflammatory conditions such as Ankylosing Spondylitis and non-radiographic Axial Spondyloarthritis. Alongside other symptoms, these conditions primarily affect the axial skeleton and connective tissue, causing pain and

Glucose – a bitter sweet for the brain

During ischemic stroke, insufficient supply of oxygen and glucose leads to severe damage of cerebral tissue. Since the most important energy substrate for the brain is glucose, high blood sugar levels could be a strategy to enhance

Key genes for amniote organ regeneration detected in lizard transcriptomes shed new hope for limb regeneration in humans

While in water-adapted vertebrates (anamniotes: fish and amphibians) organ regeneration is relevant or outstanding, including in fins or limbs, in fully terrestrial vertebrates (amniotes: reptiles, birds and mammals) regeneration is absent or rare. Aside numerous anatomical and

Type I interferons fuel adipose inflammation in obesity

When people get fat the visceral adipose tissue (VAT), fatty deposits inside the body that cling around the internal organs, get inflamed. This chronic low grade inflammation is termed metaflammation. Metaflammation has been found to contribute to

The promiscuous mineralocorticoid receptor

Hormones and nerves are the key communication systems in the human body. Nerves are like a fixed-line telephone network, capable of very fast messaging: think of the pianist’s fingers playing the Minute Waltz. Hormones are like radio,

Inflammation was regulated by polyacrylic resins in human gingival fibroblasts

Temporary fixed prostheses are an important adjunct because they protect prepared teeth and prevent exposure of dental tissues. The most commonly used temporary restorative materials in prosthodontics are PMMA, MMA, and the more modern bis-acryl composites. The

Kinase inhibitors and new treatments for asthma and COPD

Kinases are enzymes that phosphorylate proteins, leading to their activation within cells. Over 500 kinases have now been identified in human cells and they activate many processes in the cells, including the production of inflammatory mediators. Kinases

Reducing cellular stress may prevent diabetes complications

Poorly controlled diabetes is often associated with various complications including blindness, kidney failure and pain secondary to damaged nerves. However, the most common complications are those related to large blood vessel disease such as heart attacks and

IL-1 Receptor 8: a novel player in immunothrombosis

In addition to be a key component of blood hemostasis and coagulation, platelets have recently been implicated in thrombotic events associated with immune dysfunctions or inflammation. Platelets participate to innate immune responses and inflammation by releasing a

Genetic and non-genetic animal models for Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a heterogeneous group of neurobehavioral problems with genetic and environmental origins. The major neurobehavioral changes are manifested by persistent deficits in social and communication interaction, deficits in developing, understanding and maintaining relationships,