Tag Archives: inflammation

Orphans and inflammation

Many are now well-aware of the negative impact of inflammation on our health, including cancer as well as rheumatologic, metabolic and neurologic disorders.  Insults to the body either through injury (acute or chronic), or poor diet can

Fine tuning of inflammation is a key to successful limb regeneration

Complete regeneration of appendages after amputation in certain fish and amphibians has long served as a useful model for analyzing why regeneration is unsuccessful in most mammalian organs. Recent work with zebrafish, frog tadpoles, salamanders, reviewed in

HIV/AIDS-associated tryptophan depletion as part of the influence of inflammatory mediators on general nutritional status

The essential amino acid tryptophan cannot be synthesised in the body and must be acquired through dietary intake. Tryptophan is an important substrate for protein synthesis and for synthesis of the neuroactive substances serotonin, melatonin and tryptamine.

The inflamed skin in atopic eczema contributes to the disrupted skin-barrier

Atopic dermatitis, also known as atopic eczema or neurodermitis, is a chronic allergic skin disease affecting 15 – 30 % of children and 2 – 10 % of adults in industrialized countries. Patients suffer from inflamed, red

Understanding the rare disease alkaptonuria: the role of oxidative stress, inflammation and amyloidosis

Alkaptonuria (AKU) is an ultra-rare disease that was recognized among the first inborn errors of metabolism. In AKU, an altered activity of the enzyme homogentisate 1,2-dioxygenase (HGD) occurring upon gene mutation lead to a defective metabolism of

The many faces of macrophages in lung cancer

Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths than breast, prostate, and colon cancer combined. Within the past decade, the role of the immune system in the development and progression of

What new fats in processed food might do to your brain?

Modern life and the increase in the work load led us, over the years, to a great consumption of processed food with high energy density and fats. Therefore, the industry has been using lipid sources that could

ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling

Cardiovascular diseases are disorders of the heart and blood vessels which are leading to heart failure. Cardiovascular diseases correspond to 30% of all deaths in the world. The molecular processes that undergone from a healthy heart to

How the immune system is regulated by small RNAs called microRNAs to prevent self-attacks leading to autoimmunity

The ability to properly engage the different arms of the immune response is essential for protection from pathogens but also for preventing autoimmune reactions against normal tissue. Central to autoimmune prevention are a class of white blood

Blocking miR-212/132 in T cells is a potential therapy for treating colitis

Inflammatory bowel diseases (IBD), which include Crohn’s disease and ulcerative colitis, is thought to be caused by aberrant immune response to host intestinal microbiota, leading inflammation in gastrointestinal tract. The symptoms such as diarrhea, rectal bleeding, anemia,

More reasons to appreciate the Golden Spice “saffron”

Cancer remains a leading cause of morbidity and death worldwide. What is even worse is that the number of new cancer cases is projected to massive increase which would probably make it the first cause of death

In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa

Chronic inflammation of the airways is a central component in lung diseases and is frequently associated with bacterial infections. Monitoring the pro-inflammatory capability of bacterial virulence factors in vivo is challenging and usually requires invasive methods. The

Updates on the pathophysiology of systemic sclerosis

Systemic sclerosis (SSc) is a heterogeneous connective tissue disease with autoimmune component, inflammation, and progressive fibrosis of conjunctive tissues of the skin and internal organs. Lung involvements are a major cause of concern as pulmonary fibrosis and

Recharged autologous stem cells to combat cartilage defects in osteoarthritic patients

Inflammation is one of the greatest challenges for physicians and researchers working to find new strategies to regenerate patients’ damaged and deteriorated cartilage. Although humans have stem cells which can aid in many tissue repair processes throughout

Obesity protects inflamed dialysis patients

A high body mass index (BMI) is linked to longer survival terms for several serious chronic debilitating diseases. A large European epidemiological study shows that this protective effect does not apply to all patients with a high

Nonsteroidal anti-inflammatory drugs attenuate lung carcinogenesis in smoking female mice

Chronic inflammation plays a crucial role in the development of cancer in general and of cigarette smoke (CS) – related lung cancer in particular. Accordingly, anti-inflammatory drugs, among which the extensively used nonsteroidal anti – inflammatory drugs