Tag Archives: inhibitor

Chronic myeloid leukaemia: a success story in cancer therapy

Chronic myeloid leukaemia (CML) is a haematological malignancy caused by a chromosomal translocation that places the c-ABL oncogene, normally located on the long arm of chromosome 9, under the control of the breakpoint control region (BCR) on

Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade

Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,

A synthetic natural like product endowed with antiproliferative activity

The World Health Organization has reported that cancer is one of the major causes of morbidity and mortality affecting population in all countries and regions. The 2014 World Cancer Report of WHO indicated that in 2012 there

Kinase inhibitors and new treatments for asthma and COPD

Kinases are enzymes that phosphorylate proteins, leading to their activation within cells. Over 500 kinases have now been identified in human cells and they activate many processes in the cells, including the production of inflammatory mediators. Kinases

BRAF inhibitor and interferon alpha combination for melanoma treatment

In recent years approval has been granted to many therapeutic agents for the treatment of patients with metastatic melanoma. They include small molecule inhibitors, such as the selective inhibitors of the mutant BRAF (BRAF-I) or of MEK (MEK-I), and