Tag Archives: insulin

Electrically controlled insulin release

Stimuli responsive materials are promising for designing the next generation of drug delivery systems. Such materials would enable drugs to be released on-demand or in response to patient needs, specifically at the target site, minimizing side effects.

Host factors, the “Simon Says” for microbial biofilms

Microbes change their behavior, i.e., phenotype, in response to environmental clues. Since microbes, e.g. normal flora and pathogens evolved with their respective hosts, being able to recognize host-derived chemical signals provides a distinctive advantage. This is particularly

Insulin effects on pancreatic beta cells-not always what you may think

Normally, blood glucose levels are controlled within a reasonable range by the release of insulin from pancreatic beta cells in response to an increase in blood glucose levels following a meal or other glucose challenge. One of

Oligomers are building blocks of amyloid formation for insulin and its fast analog LisPro

The hormone insulin was discovered in 1921 by Banting and Best, and since that time it has been studied rigorously. At the same time first attempts were made to use insulin for treating diabetes. Insulin was the

Antipsychotic-induced severe hypoglycemia

Hyperglycemia is more common in patients with antipsychotic treatment than in the general population. However, hypoglycemia is one of the idiosyncratic potentially life-threatening adverse effects of antipsychotics. While several cases of antipsychotic-induced hypoglycemia have been reported, the

Multiple injuries (polytrauma) result in skeletal muscle wasting and insulin resistance

Polytrauma is a combination of injuries that occur over a short period of time (simultaneously or within minutes of each other). These injuries can include burn, fracture, hemorrhage, trauma to the extremities, or penetrating trauma to the

Mixing Insulin with phospholipids at the air/water interface

The Insulin monomer is unstable and tends to macroscopically aggregate in aqueous solutions during storage. This is a consequence of solid fibers formed by aggregation of monomers and dimers under low pH conditions; and causes loss of

Disguising insulin as an antibody: a Trojan horse for type 1 diabetes prevention

Type 1 Diabetes (T1D) is an auto-immune disease. These diseases appear when our own immune system, which normally protects us from foreign pathogens (viruses, bacteria,…), attacks our own cells. In the case of T1D, T lymphocytes, which

Can inhaled formoterol be used to prevent hypoglycemia?

Patients with type 1 diabetes need insulin treatment for their survival. However insulin can cause low blood sugar (or hypoglycemia); a major limiting factor for good diabetes control. Hypoglycemia occurs when there is an excess of insulin

Fatty liver disease: a condition caused by modern day lifestyle

Non-alcoholic fatty liver disease (NAFLD) refers to the build-up of fat (steatosis) in the liver that occurs in the setting of obesity and/or diabetes. Specifically, other causes such as alcohol excess or drugs or genetic conditions need

A natural compound called rutin may shade light on diabetes therapy

Diabetes and its major risk factor, obesity, have become a world-wide epidemic and cause of suffering for millions of people. There is still no drug of cure for diabetes and the currently available drugs suffer from a

Birth weight is not solely determined by genetic code

It is believed that genetic information carried by our DNA determines our metabolism and how we look. This is especially true for identical twins. The incidence of identical twins is around one in every 200 deliveries. Although

A promising new drug treatment for Alzheimer’s disease

Diabetes is a risk factor for developing Alzheimer’s disease (AD). The underlying mechanism seems to be that insulin signaling in the brain of patients with AD is very much impaired. Insulin not only controls blood sugar levels,

New effective treatments for Alzheimer and Parkinson’s disease

Alzheimer and Parkinson’s disease are the most common neurodegenerative disorders. As people are getting older than in previous generations, the number of people who are affected has increased. Unfortunately, there is no cure for these diseases. The

Another beneficial role for insulin in the brain: keeping the brain immune responses in check

Brain disease is an umbrella term, which is used to describe a broad variety of diseases ranging from epilepsy to Alzheimer’s disease to multiple sclerosis and everything in between. Brain diseases differ from each other at the

A new understanding of the mechanism of action of insulin sensitizing drugs provides insight into treating metabolic disease

It has been known for some time that there is a connection between diabetes and other diseases that increase with age, including important neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. Interestingly, all of these diseases are