Tag Archives: kidney

Urea is truly toxic: the empire strikes back

Urea is a metabolic waste product that accumulates in the body in the setting of chronic kidney disease. It is routinely measured on blood tests as a marker of kidney function (higher urea levels indicate lower kidney

A stone during pregnancy – more painful than childbirth

Kidney or ureter stones in pregnancy are a major health concern and are one of the most common causes for abdominal pain in pregnant women. Stones may lead to a blocked kidney, kidney infection which may spread

The capillary web gets lost in diseased kidneys

Main functions of the kidney are regulating ions, pH, fluid balance and blood pressure and disposing of metabolic waste products. These functions are dependent on properly working renal blood vessels, including the smallest ones, the so called

Effect of tenapanor on sodium absorption and interdialytic weight gain in patients with advanced kidney disease

The major function of the kidneys is to eliminate waste products and excess fluid from the body, through the production of urine. Patients with kidney failure need dialysis, typically three sessions per week, as an artificial replacement

Product of red grapes protects kidney from anticancer toxicity by increasing its extruding protein

Cancer chemotherapy is a double-edged tool. At one side, increasing anticancer dose may cure cancer but can cause severe toxic effects to vital organs. At the other side, decreasing the dose can protect vital organs from the

PDGF-D – a potential novel treatment for kidney diseases with scaring

Estimates suggest that a huge number of people, more than 10% of the world-population, are suffering from chronic kidney disease. Chronic kidney disease eventually leads to complete loss of kidney function, which is fatal if not treated

New way to detect kidney injury using keratins

As humans and animals have a skeleton supporting their structure, each cell has a similar microscopic skeleton termed cytoskeleton. Cytoskeleton also helps to maintain the shape and the internal organization of cells and is also involved in

Recent trends in treating kidney stones

Kidney stones are incredibly common in the United States and the prevalence is increasing at a remarkable rate.  In the United States, the chance of a man having a kidney stone at some point in his life

Can antioxidants benefit the diabetic kidney?

People who have diabetes are at high risk of developing kidney disease that may require dialysis or transplantation. This has been known for a long time but there is still a need for new ways to prevent

Long-term outcomes of robotic pyeloplasty for ureteropelvic junction obstruction

Ureteropelvic junction obstruction occurs in both adults and children when the ureter (the tube that carries urine from the kidney to the bladder) becomes blocked, preventing the flow of urine out of the kidney.  Surgery is often

Nonadherence to immunosuppressive therapy in kidney transplant recipients

End-stage kidney disease (ESKD) is an increasing worldwide illness that compels patients to accept either dialysis or kidney transplantation that is the best choice because ensures high quality of life. But, living or cadaveric kidney donation is

Towards organs on demand: a new platform for successful kidney organogenesis

The ultimate treatment for end-stage renal disease is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a

Animal-free platforms for the efficient and accurate prediction of kidney toxicity in humans

Tens of thousands of chemicals are used in food, cosmetics and consumer products. In addition, humans are exposed to drugs and environmental toxicants. Safety testing based on animals is too slow and too costly for screening the

Should we use gentamicin cream to prevent exit-site infection in peritoneal dialysis?

Peritoneal Dialysis (PD) is one of the treatment modalities for kidney failure. With PD, the toxins from the blood are removed through the abdominal membrane (peritoneum) into the fluid, which is put into the abdomen through a

Treatment holidays for patients with metastatic kidney cancer

Targeted therapy is the standard treatment of patients with metastatic cancer of the kidney. The best current therapies target the tumour vasculature thereby blocking the access of the tumour to nutrients and limiting possibility of spreading to

Renal cell carcinoma: can we identify patients with advanced disease?

Kidney cancer is among the 10 most common cancers in both men and women with approximately 61,560 new cases and 14,080 deaths from this disease expected in 2015. Clear cell renal cell carcinoma (ccRCC) is the most