Tag Archives: kinase

Identification of a new T cell regulator

T-cell receptor (TCR) signaling is mediated by the activation of protein-tyrosine kinases such as p56lck and ZAP-70. In mature T-cells, CD4 and CD8 molecules bind to p56lck which then phosphorylates the intracellular immune-receptor tyrosine-based activation motifs (ITAM)

Mechanism of the tumor suppressive properties of glycodelin

Malignant growth in cancer is characterized by loss of cell differentiation, uncontrolled proliferation and resistance to apoptosis. In some cases it is possible to revert malignant cells back to normal. However, this process is not very well

Kinase inhibitors and new treatments for asthma and COPD

Kinases are enzymes that phosphorylate proteins, leading to their activation within cells. Over 500 kinases have now been identified in human cells and they activate many processes in the cells, including the production of inflammatory mediators. Kinases

Control of plant architecture by gravity

Plants are permanently tethered to the soil and thus, unlike animals, they cannot physically escape from harmful situations. Instead, they have evolved mechanisms to adapt their growth to an ever-changing environment. A simple example of this phenomenon,

Genes regulating Wolbachia cell division

Bacterial infection underlies many devastating diseases, yet bacteria also play a central role in the maintenance of human health and well-being.  From aiding in host food digestion and limiting unfavorable bacterial growth to causing paralysis or even

Making drug discovery more efficient: predicting drug side effects in early screening efforts

Drug research and development is a complex and expensive process that begins with initial screening steps of candidate chemical compounds. Compounds that appear to have the desired potency against a specific cellular target or pathway are further

Glycogen localisation of AMPK is a regulated process

AMP-activated protein kinase (AMPK) is a metabolic master kinase that plays a key role in maintaining energy homeostasis at cellular and whole body level. Recent evidence links AMPK activation to health benefits, such as increased longevity and

Dissecting how cells communicate to prevent cancer relapse

Protein kinases are a class of enzymes that are responsible for the transfer of phosphates onto other proteins. These phosphate groups, although small, can change the behaviour of the protein itself, or the behaviour of those it

Silence the uncontrolled cancer cells’ growth by controlling cellular senescence

When toxic damage caused by environmental or internal stressors accumulates cells can either stop proliferation permanently ( cellular senescence ) or die. Cell death is a common goal of existing cancer therapies, yet cellular senescence is increasingly

Emerging insights from the green world into growth and ageing

Unlike animals whose form and fate is largely determined a brief embryogenesis, plants typically elaborate variable forms more gradually, and in some cases can grow for thousands of years. These differences can be largely attributed to distinct