Tag Archives: liver

A combination of medical therapy and liver transplantation save children with acute liver failure

Acute liver failure (ALF) in children is defined as a severe impairment of liver function characterized by biochemical evidence of acute liver injury, coagulopathy (INR ≥2.0) regardless of the presence of hepatic encephalopathy (HE) and no history

Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets

Platelets play a key role in the prevention of excessive blood loss through the formation of a thrombus at the site of vessel damage. Hyper-reactive platelets lead to unwanted, excessive platelet activation and contribute to atherothrombosis that

Vitellogenesis: not only in the liver and not only in females

Vitellogenin (VTG) is an estrogen-dependent, females-specific yolk precursor protein naturally synthesized during the reproductive period in the liver of oviparous vertebrates. Released in blood, VTG is taken from the growing oocytes by micropinocytosis and used as nourishment

A new kind of human immune cell that cannot leave the liver

Natural Killer (NK) cells are immune cells that are found in the blood and protect the body by killing infected and cancerous cells. NK cells can also be found in large numbers in some organs, including the

Disparities resulting from variations in regional donor supply and liver transplant tourism

In the United States, the Organ Procurement and Transplantation Network (OPTN) develops national policies that determine how donated organs are collected, matched, and distributed with candidates on the transplantation waitlist. Currently, the nation is divided into 11

Vodka and wine consumption: good for your liver?

Approximately 50 million Americans are affected by metabolic syndrome. Metabolic syndrome is defined as hypercholesterolemia, hypertriglyceridemia, high blood pressure and glucose intolerance leading to type 2 diabetes mellitus. Patients with metabolic syndrome have an increased risk of

Biotransformation of bufadienolides in human liver microsomes

Bufadienolides are a family of cardiac aglycone compounds with the inhibitory activity of Na+/K+-ATPase. They exist extensively in both animal and plant species, such as Crassulaceae, Ranunculaceae, Bufonidae and Colubridae families. In traditional Chinese medicine, bufadienolides are

Polar bears and flame retardant chemicals as environmental pollutants

Polybrominated diphenyl ethers (PBDEs) are man-made chemicals that were used on many industrial and consumer products to reduce fire risk. The commercial PBDE mixture that was used extensively in North America for application to polyurethane foam, textiles

Nutritional therapy may slow down cirrhosis

One in 400 citizens of western industrialized countries suffers from chronic liver disease or its end-stage, liver cirrhosis. The only definite cure for this is a liver transplant, but the scarcity of organs and required immunosuppression render

The youth hormone DHEA in the treatment of liver cancer: die another way

Hepatocellular carcinoma (HCC) is a common form of malignant liver tumor and one of the leading causes of death all over the world. As for other types of cancer, many drugs have been developed and tested with

New potential approach to nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is emerging as one of the most common chronic liver disease, affecting up to 30% of the general population worldwide. NAFLD is characterized by hepatic fat accumulation exceeding 5% of liver weight,

Lowering the burden of liver disease in the UK: a blueprint for change

Liver disease is the third biggest cause of premature death in the UK and the number of deaths from liver disease is on the rise (Fig. 1). People can develop liver disease for a number of reasons

Food and Nutrition cause liver and brain diseases with diabetes in the developing and developed world

In the world the consumption of a healthy diet is essential to prevent diseases such as obesity, diabetes and brain diseases. New discoveries in medicine indicate that a diet that is low in fat and carbohydrate lower

Cerium oxide nanoparticles may be of therapeutic value in chronic liver disease

What is this? We use Cerium oxide NPs (CeO2NPs) to treat cirrhosis in model rats and we observe how it has dramatic beneficial effects in reducing inflammation and allowing tissue reparation What makes nanoceria very appealing is

Real life treatment of hepatocellular carcinoma: impact of deviation from guidelines recommended therapy

Primary liver cancer is one of the most common cancers at the global level. The outcome of hepatocellular carcinoma (HCC) is related to the extent of both tumor and liver disease, which influence the applicability and efficacy

Fatty liver disease: a condition caused by modern day lifestyle

Non-alcoholic fatty liver disease (NAFLD) refers to the build-up of fat (steatosis) in the liver that occurs in the setting of obesity and/or diabetes. Specifically, other causes such as alcohol excess or drugs or genetic conditions need