Tag Archives: liver

Vodka and wine consumption: good for your liver?

Approximately 50 million Americans are affected by metabolic syndrome. Metabolic syndrome is defined as hypercholesterolemia, hypertriglyceridemia, high blood pressure and glucose intolerance leading to type 2 diabetes mellitus. Patients with metabolic syndrome have an increased risk of

Biotransformation of bufadienolides in human liver microsomes

Bufadienolides are a family of cardiac aglycone compounds with the inhibitory activity of Na+/K+-ATPase. They exist extensively in both animal and plant species, such as Crassulaceae, Ranunculaceae, Bufonidae and Colubridae families. In traditional Chinese medicine, bufadienolides are

Polar bears and flame retardant chemicals as environmental pollutants

Polybrominated diphenyl ethers (PBDEs) are man-made chemicals that were used on many industrial and consumer products to reduce fire risk. The commercial PBDE mixture that was used extensively in North America for application to polyurethane foam, textiles

Nutritional therapy may slow down cirrhosis

One in 400 citizens of western industrialized countries suffers from chronic liver disease or its end-stage, liver cirrhosis. The only definite cure for this is a liver transplant, but the scarcity of organs and required immunosuppression render

The youth hormone DHEA in the treatment of liver cancer: die another way

Hepatocellular carcinoma (HCC) is a common form of malignant liver tumor and one of the leading causes of death all over the world. As for other types of cancer, many drugs have been developed and tested with

New potential approach to nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is emerging as one of the most common chronic liver disease, affecting up to 30% of the general population worldwide. NAFLD is characterized by hepatic fat accumulation exceeding 5% of liver weight,

Lowering the burden of liver disease in the UK: a blueprint for change

Liver disease is the third biggest cause of premature death in the UK and the number of deaths from liver disease is on the rise (Fig. 1). People can develop liver disease for a number of reasons

Food and Nutrition cause liver and brain diseases with diabetes in the developing and developed world

In the world the consumption of a healthy diet is essential to prevent diseases such as obesity, diabetes and brain diseases. New discoveries in medicine indicate that a diet that is low in fat and carbohydrate lower

Cerium oxide nanoparticles may be of therapeutic value in chronic liver disease

What is this? We use Cerium oxide NPs (CeO2NPs) to treat cirrhosis in model rats and we observe how it has dramatic beneficial effects in reducing inflammation and allowing tissue reparation What makes nanoceria very appealing is

Real life treatment of hepatocellular carcinoma: impact of deviation from guidelines recommended therapy

Primary liver cancer is one of the most common cancers at the global level. The outcome of hepatocellular carcinoma (HCC) is related to the extent of both tumor and liver disease, which influence the applicability and efficacy

Fatty liver disease: a condition caused by modern day lifestyle

Non-alcoholic fatty liver disease (NAFLD) refers to the build-up of fat (steatosis) in the liver that occurs in the setting of obesity and/or diabetes. Specifically, other causes such as alcohol excess or drugs or genetic conditions need

More reasons to appreciate the Golden Spice “saffron”

Cancer remains a leading cause of morbidity and death worldwide. What is even worse is that the number of new cancer cases is projected to massive increase which would probably make it the first cause of death

Liver X receptor beta, the link between thyroid hormone regulation and the browning of white fat

Everyone agrees that when our intake of sugar, fat and protein exceeds the body’s need for nutrition, excess is stored as fat. Fat in the form of white adipocytes is the body’s reserve of energy, which is

The effect of a hydrogen sulfide releasing molecule on the cold storage of livers from dead donor rats

The liver is the largest organ inside our body and, as long as it keeps healthy, it will be in charge of a wide range of mechanisms that are essential for life. Liver will filter the blood

The infusion of haematopoietic stem cells in patients with liver insufficiency

Cirrhosis, the end result of long-term liver damage, and its related morbidity represnt a significant burden on health care worldwide. Liver transplantation is the only definitive therapeutic option for those patients. However, the paucity of donors, the incidence

The portal venous system in liver cirrhosis: not yet a gray zone

Liver cirrhosis is a complex disease involving many systems, mainly located inside the abdominal cavity. The clinical diagnosis today is usually followed by laboratory, endoscopic, radiological examinations, among which the sectional imaging tools, ultrasound, computed tomography  and