Tag Archives: lung cancer

Surrogate endpoints for overall survival in lung cancer patients treated with PD-1/PD-L1 blockade

Anti PD-1/PD-L1 antibodies are becoming key therapies in the treatment for advanced non-small-cell lung cancer (NSCLC). Surrogate endpoints for overall survival (OS) such as tumor response and progression-free survival (PFS) are useful to detect drug efficacy earlier,

Lung cancer imaging before surgery and the role of brain MRI

Lung cancer kills more people each year than any other cancer worldwide. The best chance at curing the cancer is with surgery, however not all lung cancers can be taken out. Surgeons use a variety of imaging

A new test to select more effective treatments for lung cancer

Sadly, the majority of patients with Lung Cancers who cannot be treated by surgery to remove their tumour, die within a few years. Small numbers are beginning to benefit from chemotherapies which target very specific types of

A mild form of dermatomyositis as a prodromal sign of lung cancer: looking behind the skin

Dermatomyositis is a rare inflammatory disease characterized by specific skin findings and inflammatory lesions in the muscle biopsy. The most common clinical signs of dermatomyositis include an erythema over the face, neck and upper trunk known as

Fluorescent carbon dots integrated hydrogels for lung cancer therapy

Cancer is considered as one of the leading cause of death worldwide. Due to the ever changing lifestyle of the modern society, the incidence of cancer is on the rise. Lung cancer is the most frequently diagnosed

Three dimensional quality assurance protocol for thoracic and genitourinary radiation therapy

After cancer diagnosis one treatment option is the use of external radiation. As the radiation traverses the patient it deposits most of its energy in the tumor, which causes irreparable damage to the cancer cells. One type

Side effects of radiation therapy: Why me?

Most lung cancers are treated with radiation therapy, often in high doses.  Although these treatments are absolutely required to prolong life (by killing the tumor or slowing its growth), radiation treatment can have negative side effects that

The many faces of macrophages in lung cancer

Lung cancer is the leading cause of cancer death worldwide, accounting for more deaths than breast, prostate, and colon cancer combined. Within the past decade, the role of the immune system in the development and progression of

Diminished disease-free survival following lung cancer surgery

Treatment of lung cancer requires removal of a portion of a vital organ, which may reduce life expectancy. This would be acceptable when surgery prevents death from cancer. It is harmful in cases identified by screening in

Diagnosis of small cell lung carcinoma metastases

Cancer is defined by unscheduled cellular growth and metastatic spread into other organs of the body. Tumor cells gain their capacities form genetic alterations, also known as mutations, leading to altered protein functions and signaling pathways. Tumors

Using tumor DNA to refine lung cancer staging and treatment

The treatment of non-small cell lung cancer (NSCLC) is guided by disease stage as assessed by clinical and pathologic criteria.  Clinical tumor stage is determined by imaging including computed tomography (CT) scans, magnetic resonance imaging (MRI), positron

Many factors determine prognosis in resected lung cancer. Is visceral pleural involvement one of them?

Prognosis after pulmonary resection for primary lung cancer is closely related to tumor stage, since stage predicts the risk recurrence. Lung cancer staging is based on the TNM system that evaluates tumor size and contiguous tissue infiltration